Review – Mediators of Asthma SeriesReactive Oxygen Species as Mediators in Asthma
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Role of oxidative stress in the severity of SARS-COV-2 infection
2023, COVID-19 in Alzheimer's Disease and DementiaStressed out - The role of oxidative stress in airway smooth muscle dysfunction in asthma and COPD
2022, Free Radical Biology and MedicineCitation Excerpt :AKAPs signal via protein kinase A (PKA) with disruption of AKAP-PKA interactions both augmenting CSE induced IL-8 release from ASM, and diminishing the suppression of this release by formoterol, suggesting that CSE induced changes in AKAP expression could compromise the anti-inflammatory effects of formoterol [117]. ROS are also involved in the down regulation of β-adrenergic signalling [279], which could have implications for the bronchodilatory effects of β-agonists, confounding the effects of ROS on promoting ASM contractility described in this review. In this review we have summarised studies using data from primary airway, bronchial or tracheal smooth muscle cells that assess the role of oxidative stress and ROS in ASM dysfunction relevant to asthma and COPD.
Bridging micro/nano-platform and airway allergy intervention
2022, Journal of Controlled ReleaseSearching for Inflammatory and Oxidative Stress Markers Capable of Clustering Severe Asthma
2021, Archivos de Bronconeumologia
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Author for correspondence: Paul A. J. Henricks, Department of Pharmacology and Pathophysiology, P.O. Box 80.082, 3508 TB Utrecht, The Netherlands. Tel.: 31-30-2537358 Fax: 31-30-2537420 E-mail: [email protected]