Regular ArticleMultidrug transporters from bacteria to man: similarities in structure and function
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Block copolymer micelles as nanoreactors for the synthesis of gold nanoparticles
2019, Materials for Biomedical Engineering: Inorganic Micro- and NanostructuresP-Glycoprotein
2013, Brenner's Encyclopedia of Genetics: Second EditionReversal of efflux mediated antifungal resistance underlies synergistic activity of two monoterpenes with fluconazole
2013, European Journal of Pharmaceutical SciencesCitation Excerpt :In C. albicans, efflux pumps in the ABC superfamily include Cdr1p and Cdr2p, coded by CDR1 and CDR2, respectively (Sanglard et al., 1997; Wada et al., 2002). Efflux pumps belonging to this superfamily are present ubiquitously and are structurally similar in organisms ranging from prokaryote cells to mammals (van Veen and Konings, 1997). Over-expression of the plasma membrane efflux pump genes MDR1, FLU1, CDR1, and CDR2 and genetic alterations in the ERG11 gene encoding lanosterol 14α-demethylase are the main mechanisms of azole drug resistance in Candida.
Microparticles and their emerging role in cancer multidrug resistance
2012, Cancer Treatment ReviewsCitation Excerpt :Each TMD typically consists of six putative α-helices (Fig. 2A). Members of this cluster share approximately 60% overall sequence homology and display similar hydropathy profiles and secondary structures.19 Classic members include the transporters encoded by the pfMDR1 gene of Plasmodium falciparum,20 the ehPgp gene product of Entamoeba histolytica,21 the ldmdr1 gene product of Leishmania donovani22 and the Cdr1p gene product of Candida albicans.23
In vitro folding and assembly of the Escherichia coli ATP-binding cassette transporter, BtuCD
2011, Journal of Biological ChemistryCitation Excerpt :ABC proteins transport diverse substrates across cellular membranes (15, 16) and are found in all organisms and in humans their mis-folding and mis-assembly is implicated in several genetic diseases (17–21). Other ABC transporters contribute to the resistance of cancer cells to chemotherapeutic agents (22) and to antibiotic resistance in bacterial cells (23, 24). Here, we use the Escherichia coli ABC transporter, BtuCD as a model system for investigating the in vitro folding and assembly of a multi-subunit membrane protein complex.
Chapter 2 Alkaloids with Antiprotozoal Activity
2008, Alkaloids: Chemistry and BiologyCitation Excerpt :Additionally, some plant-derived alkaloids have potential as modulators of the multidrug resistance (MDR) phenotype. Transporters of the ATP-Binding Cassette (ABC) family are known to provide the basis of MDR in mammalian cancer cells and in pathogenic yeasts, fungi, bacteria, and parasitic protozoa (396–404). One strategy to reverse the resistance of cells expressing ABC transporters is a combined and simultaneous use of chemotherapeutic agents and modulators.
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