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Multidrug transporters from bacteria to man: similarities in structure and function

https://doi.org/10.1006/scbi.1997.0064Get rights and content

Abstract

Organisms ranging from bacteria to man possess trans-membrane transporters which confer resistance to toxic compounds. Underlining their biological significance, prokaryotic and eukaryotic multidrug transport proteins are very similar in structure and function. Therefore, a study of the factors which determine the substrate specificity and energy coupling to drug translocation in ‘simple’ microorganisms has significance for multidrug resistance of mammalian cells. This chapter represents a comprehensive review in which we will summarize the current state of knowledge on three major aspects of drug efflux-based multidrug resistance: (i) the functional and structural similarities among secondary and ABC-type drug transporters encountered in prokaryotic and eukaryotic cells; (ii) the molecular mechanism of these transporters; and (iii) their potential physiological role.

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