Regular ArticleCharacterization of Chemical Allergens as a Function of Divergent Cytokine Secretion Profiles Induced in Mice
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How to assess respiratory sensitization of low molecular weight chemicals?
2020, International Journal of Hygiene and Environmental HealthCitation Excerpt :However, there is a growing consensus about the cellular requirements: contact allergy is closely associated with the elicitation of selective T helper (Th)-1 type immune responses whereas chemical respiratory allergy is closely associated with T helper (Th)-2 type immune responses. This is based on experimental studies in which chemical respiratory allergens have been found to induce preferential Th2-type T cell responses (Dearman et al., 1995, 1996; 2005; Van Och et al., 2002; Kimber et al., 2011) and there are data indicating that a similar Th2 selectivity is found in humans also (Ouyang et al., 2013; Newell et al., 2013; Kimber et al., 2014c). See for more information on the mechanism of type 2 immunopathology e.g. the paper of Samuchiwal and Boyce (2018).
Are skin sensitisation test methods relevant for proteins?
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2017, Regulatory Toxicology and PharmacologyBehaviour of chemical respiratory allergens in novel predictive methods for skin sensitisation
2017, Regulatory Toxicology and PharmacologyMolecular profiling of contact dermatitis skin identifies allergen-dependent differences in immune response
2014, Journal of Allergy and Clinical Immunology