Regular ArticleCannabinoid Receptors CB1 and CB2: A Characterization of Expression and Adenylate Cyclase Modulation within the Immune System☆
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Receptor mechanisms underlying the CNS effects of cannabinoids: CB<inf>1</inf> receptor and beyond
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2021, Pharmacology Biochemistry and BehaviorCitation Excerpt :Neuronal CB1R are known to mediate the ‘cannabimimetic’ behavioral effects of cannabinoids, including acute antinociception, decreased locomotion, catalepsy, as well as hypothermia, (Little et al., 1988; Ledent et al., 1999; Grim et al., 2016) and CB1R agonism is also associated with activation of anti-inflammatory mechanisms (Richardson et al., 1998; Borner et al., 2009; Newton et al., 2009). CB2 receptors (CB2R) are located on immune cells (Carayon et al., 1998; Galiegue et al., 1995; Munro et al., 1993; Schatz et al., 1997) and on a few discrete adult neuronal populations (Onaivi et al., 2008) within the brainstem (Van Sickle et al., 2005), the hippocampus (Stempel et al., 2016), as well as on neural stem and progenitor cells (Jiang et al., 2007; Molina-Holgado et al., 2007). CB2R agonists produce anti-inflammatory signaling cascades without the cannabimimetic-like effects often seen with CB1R agonists (Rahn et al., 2011).
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This work was supported by funds from NIDA Grants DA07908 and DA09171 and NIEHS Training Grant ES07087.
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Current address: Abbott Laboratories, D38A, AP-51, 200 Abbott Park Road, Abbott Park, IL 60064-3537.
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Department of Life Sciences, Korea Advanced Institute of Science and Technology, Taejon, Korea.