Regular ArticleInhibition of Androgen Receptor-Dependent Transcriptional Activity by DDT Isomers and Methoxychlor in HepG2 Human Hepatoma Cells☆,☆☆
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Relationship between agrochemical compounds and mammary gland development and breast cancer
2020, Molecular and Cellular EndocrinologyCitation Excerpt :Methoxychlor is a structural analog of dichlorodiphenyltrichloroethane (DDT) (Reuber, 1980) and has been found in human tissue samples (Eldakroory et al., 2017) and breast milk (Kao et al., 2019). Methoxychlor binds to ERs (Bulger et al., 1978), and it has been shown that its metabolite (2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane) can have either estrogenic activity through ESR1 or antiestrogenic activity through ERbeta, and also act as an antagonist of the AR (Gaido et al., 1999, 2000; Maness et al., 1998). Moreover, when rats are treated with methoxychlor, reproductive abnormalities can be observed in both male and female animals and uterine dysplasia and less mammary alveolar development can be observed in females (Chapin et al., 1997; Okazaki et al., 2001).
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CPRG, chlorophenol red-β-d-galactopyranoside;p,p′-DDD, 1,1′-(2,2-dichloroethylidene)bis(4-chlorobenzene);o,p′-DDD, 1-chloro-2-(2,2-dichloro-1-(4-chlorophenyl)ethyl)-benzene;p,p′-DDE, 1,1′-(dichloroethylidene)bis(4-chlorobenzene);o,p′-DDE, 1-chloro-2-(dichloro-1-(4-chlorophenyl)ethyl)-benzene;p,p′-DDT, 1,1′-(2,2,2-trichloroethylidene)bis(4-chlorobenzene);o,p′-DDT, 1-chloro-2-(2,2,2-trichloro-1-(4-chlorophenyl)ethyl)-benzene; DHT, dihydrotestosterone; HPTE, 2,2-bis(p-hydroxyphenyl)-1,1,1-trichloroethane.
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B. Weintraub
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