Regular ArticleRole of Fas–Fas Ligand Interactions in 2,3,7,8-Tetrachlorodibenzo- p-dioxin (TCDD)-Induced Immunotoxicity: Increased Resistance of Thymocytes from Fas-Deficient (lpr) and Fas Ligand-Defective (gld) Mice to TCDD-Induced Toxicity
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2024, Science of the Total EnvironmentTCDD attenuates EAE through induction of FasL on B cells and inhibition of IgG production
2021, ToxicologyCitation Excerpt :We are not the first to identify FasL upregulation as a possible mechanism for immune suppression by TCDD. Upregulation of FasL by TCDD was shown to be an important pathway for thymic involution produced by TCDD (Camacho et al., 2005; Kamath et al., 1999), although there are a couple of studies showing that FasL upregulation by TCDD was not a major contributor (Beamer et al., 2019; Nagai et al., 2006). The differences in the roles for TCDD-mediated increases in FasL in thymic involution might be related to the cell type on which FasL is expressed; for instance, FasL expression in thymic CD45- stromal cells was found to be important for thymic involution (Camacho et al., 2005).
Immunotoxicology of Halogenated Aromatic Hydrocarbons
2018, Comprehensive Toxicology: Third EditionOxidative Stress, Unfolded Protein Response, and Apoptosis in Developmental Toxicity
2015, International Review of Cell and Molecular BiologyActivation of the aryl hydrocarbon receptor reduces the number of precursor and effector T cells, but preserves thymic CD4<sup>+</sup>CD25<sup>+</sup>Foxp3<sup>+</sup> regulatory T cells
2012, Toxicology LettersCitation Excerpt :For a long time TCDD is known to induce immune suppression, to affect the differentiation of thymic precursor T cells and to induce thymic atrophy (Fine et al., 1990; Hundeiker et al., 1999; Kremer et al., 1994; Lai et al., 1997; Laiosa et al., 2003; Lundberg et al., 1990; Lundberg, 1991; Silverstone et al., 1994). A single dose of 0.1 μg/kg BW TCDD is already effective in decreasing thymocyte numbers in mice (Kamath et al., 1999). Discussion is ongoing how TCDD induces apoptosis of thymocytes resulting in thymic atrophy.
Chlorpyrifos-induced oxidative stress and histological changes in retinas and kidney in rats: Protective role of ascorbic acid and alpha tocopherol
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To whom correspondence should be addressed at the Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061. E-mail: [email protected].