Abstract
General anesthetics have been in clinical use for more than 160 years. Nevertheless, their mechanism of action is still only poorly understood. In this review, we describe studies suggesting that inhibitory ligand-gated ion channels are potential targets for general anesthetics in vitro and describe how the involvement of y-aminobutyric acid (GABA)A receptor subtypes in anesthetic actions could be demonstrated by genetic studies in vivo.
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© 2008 Springer-Verlag Berlin Heidelberg
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Zeller, A. et al. (2008). Inhibitory Ligand-Gated Ion Channels as Substrates for General Anesthetic Actions. In: Schüttler, J., Schwilden, H. (eds) Modern Anesthetics. Handbook of Experimental Pharmacology, vol 182. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-74806-9_2
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DOI: https://doi.org/10.1007/978-3-540-74806-9_2
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-72813-9
Online ISBN: 978-3-540-74806-9
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