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Adenosine Receptors in Wound Healing, Fibrosis and Angiogenesis

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Book cover Adenosine Receptors in Health and Disease

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 193))

Abstract

Wound healing and tissue repair are critical processes, and adenosine, released from injured or ischemic tissues, plays an important role in promoting wound healing and tissue repair. Recent studies in genetically manipulated mice demonstrate that adenosine receptors are required for appropriate granulation tissue formation and in adequate wound healing. A2A and A2B adenosine receptors stimulate both of the critical functions in granulation tissue formation (i.e., new matrix production and angiogenesis), and the A1 adenosine receptor (AR) may also contribute to new vessel formation. The effects of adenosine acting on these receptors is both direct and indirect, as AR activation suppresses antiangiogenic factor production by endothelial cells, promotes endothelial cell proliferation, and stimulates angiogenic factor production by endothelial cells and other cells present in the wound. Similarly, adenosine, acting at its receptors, stimulates collagen matrix formation directly. Like many other biological processes, AR-mediated promotion of tissue repair is critical for appropriate wound healing but may also contribute to pathogenic processes. Excessive tissue repair can lead to problems such as scarring and organ fibrosis and adenosine, and its receptors play a role in pathologic fibrosis as well. Here we review the evidence for the involvement of adenosine and its receptors in wound healing, tissue repair and fibrosis.

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Abbreviations

ADA:

Adenosine deaminase

AR:

Adenosine receptor

bFGF:

Basic fibroblast growth factor

IFN:

Interferon

IL:

Interleukin

MMP:

Matrix metalloproteinase

NECA:

Adenosine 5′ -N-ethyluronamide

TGF:

Transforming growth factor

TNF-α:

Tumor necrosis factor alpha

VEGF:

Vascular endothelial growth factor

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Authors and Affiliations

  1. Division of Cardiovascular Medicine, 360 PRB, Vanderbilt University, 2220 Pierce Ave, Nashville, TN, 37232-6300, USA

    Igor Feoktistov

  2. Division of Clinical Pharmacology, 556 RRB, Vanderbilt University, 2220 Pierce Ave, Nashville, TN, 37232, USA

    Italo Biaggioni

  3. Department of Medicine, NYU School of Medicine, Paul R. Esserman Professor of Medicine, Division of Clinical Pharmacology, 550 First Ave., NBV16N1, New York, NY, 10016, USA

    Bruce N. Cronstein

Authors
  1. Igor Feoktistov
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  2. Italo Biaggioni
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  3. Bruce N. Cronstein
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Corresponding author

Correspondence to Bruce N. Cronstein .

Editor information

Editors and Affiliations

  1. Endacea, Inc.,, Davis Drive 2, Research Triangle Park, 27709-2076, U.S.A.

    Constance N. Wilson

  2. Health Sciences Center, West Virginia University, Health Sciences S. 2267, Morgantown, 26506-9104, U.S.A.

    S. Jamal Mustafa

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© 2009 Springer-Verlag Berlin Heidelberg

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Feoktistov, I., Biaggioni, I., Cronstein, B.N. (2009). Adenosine Receptors in Wound Healing, Fibrosis and Angiogenesis. In: Wilson, C., Mustafa, S. (eds) Adenosine Receptors in Health and Disease. Handbook of Experimental Pharmacology, vol 193. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-89615-9_13

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