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A Look at Receptor Efficacy. From the Signalling Network of the Cell to the Intramolecular Motion of the Receptor

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Book cover The Pharmacology of Functional, Biochemical, and Recombinant Receptor Systems

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 148))

Abstract

In this article, we examine the multiple connotations of the idea of ligand efficacy, from the macroscopic complexity of the signalling network in the living cell to the microscopic complexity of the single-protein macromolecule. Our analysis consists of two parts.

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Authors
  1. H. O. Onaran
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  2. A. Scheer
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  3. S. Cotecchia
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  4. T. Costa
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Editors and Affiliations

  1. Department of Receptor Biochemistry, Glaxo Wellcome Research and Development, 5 Moore Drive, Research Triangle Park, 27709, NC, USA

    Terry Kenakin Ph.D. (Principal Research Scientist) (Principal Research Scientist)

  2. Department of Pharmacology, The University of Melbourne, 3010, Parkville, VIC, Australia

    James A. Angus Ph.D. FAA (Head) (Head)

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Onaran, H.O., Scheer, A., Cotecchia, S., Costa, T. (2000). A Look at Receptor Efficacy. From the Signalling Network of the Cell to the Intramolecular Motion of the Receptor. In: Kenakin, T., Angus, J.A. (eds) The Pharmacology of Functional, Biochemical, and Recombinant Receptor Systems. Handbook of Experimental Pharmacology, vol 148. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-57081-0_9

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