Protein Synthesis and Translation Inhibitors

Abstract

Studies concerning selectivity, site, and mode of action of translation inhibitors have been widely developed and the subject has been reviewed repeatedly in the last fifteen years (Gale, 1963; Newton, 1965; Newton and Reynolds, 1966; Gottlieb and Shaw, 1967a; Vázquez and Monro, 1967; Weisblum and Davies, 1968; Pestka, 1971; Muñoz, García-Ferrandiz and Vázquez, 1972; Gale et al., 1972; Kaji, 1973; Vázquez, 1974; Corcoran and Hahn, 1975; Pestka, 1977; Vázquez, 1978a). This study will be concerned mainly with the present state of the problem. A complete survey of the literature will not be possible in this contribution and the above reviews should be very useful to readers interested in different aspects of the problem. Furthermore, there are a number of reviews concerning the chemistry, biosynthesis, toxicology, inhibitory spectra of the different inhibitors (Korzybski, Kowszyk-Gindifer and Kurylowicz, 1967a, 1967b; Gottlieb and Shaw, 1967a, 1967b; Glasby, 1976) and mechanism of drug resistance (Benveniste and Davies, 1973a; Mitsuhashi, Rosival and Krčméry, 1975; Mitsuhashi, 1977; Mitsuhashi and Hashimoto, 1977) which should be very useful to readers who are concerned with these topics.