Abstract
In rat portal vein myocytes, α2A-adrenoceptors activate voltage-dependent Ca2+ channels via a transduction pathway requiring protein kinase C activation mediated by a pertussis-toxin-sensitive G-protein. As revealed by the use of antibodies directed against the different α-subunits expressed in portal vein myocytes, we show that the clonidine-induced stimulation of voltage-dependent Ca2+ channels is mainly mediated by a Gi1–2-protein.
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Macrez-Leprêtre, N., Ibarrondo, J., Arnaudeau, S. et al. A Gi1–2-protein is required for α2A-adrenoceptor-induced stimulation of voltage-dependent Ca2+ channels in rat portal vein myocytes. Pflugers Arch. 430, 590–592 (1995). https://doi.org/10.1007/BF00373897
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DOI: https://doi.org/10.1007/BF00373897