Abstract
The effects of a number of drugs that deplete catecholamines or block their receptors were investigated on the levels of free amino acids and glutamate decarboxylase activity in rat striatum and substantia nigra, in an attempt to clarify the possible links between catecholamine and amino acid transmitter function. While none of the drugs tested were significantly active in the striatum, profound changes occurred in the substantia nigra. The data are discussed in relation to the possible mechanisms involved.
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References
Berl, S., andFrigyesi, T. 1969. Effect of reserpine on turnover of glutamate, glutamine, aspartate and GABA labelled with [1-14C]acetate in caudate nucleus, thalamus and sensorimotor cortex of cat. Brain Res. 14:683–695.
Berl, S., andFrigyesi, T. 1969. Effects of reserpine on amino acid levels in feline caudate nucleus, thalamus and motor cortex and metabolism of [14C]acetate. Cytobioscience 1A:37–44.
Nicklas, W. J., andBerl, S. 1973.In vivo studies on the effect of 5-hydroxydopamine on amino acid metabolism in brain. Brain Res. 61:343–356.
Koyuncuoĝlu, H. 1974. The effects of chronic re the free amino acid levels of rat brain. Psychopharmacology 37:87–90.
Kim, J-S., andHassler, R. 1975. Effects of acute haloperidol on the gammaaminobutyric acid system in rat striatum and substantia nigra. Brain Res. 88:150–153.
Lane, J. D., Smith, J. E., Shea, P. A., andMcBride, W. J. 1976. Neurochemical changes following the administration of depletors of biogenic amines. Life Sci. 19:1663–1668.
Berl, S., Nicklas, W. J., andClarke, D. P. 1975. Coupling of catecholamines and amino acid metabolism in the nervous system. Pages 465–471,in Santini, M. (ed.), Golgi Centennial Symposium Proceedings, Raven Press, New York.
Goldstein, M., Anagnoste, B., Batitista, W. S., Owens, W. S., andNakatani, S. 1969. Studies of amines in the striatum of monkeys with nigral lesions. J. Neurochem. 16:645–653.
Connor, J. D. 1970. Caudate nucleus neurones: Correlation of the effects of substantia nigra stimulation with iontophoretic dopamine. J. Physiol. Lond. 208:691–703.
Dray, A., andStraughan, D. W. 1976. Synaptic mechanisms in the substantia nigra. J. Pharm. Pharmacol. 28:400–405.
Roberts, P. J., Keen, P., andMitchell, J. F. 1973. The distribution and axonal transport of free amino acids and related compounds in the dorsal sensory neuron of the rat, as determined by the dansyl reaction. J. Neurochem. 21:199–209.
Collins, G. G. S. 1972. Gaba-2-oxoglutarate transaminase, glutamate decarboxylase and half-life of GABA in different areas of rat brain. Biochem. Pharmacol. 21:2849–2858.
Glowinski, J., andBaldessarini, R. J. 1966. Metabolism of norepinephrine in the central nervous system. Pharmacol. Rev. 18:1201–1238.
Morrison, A. B., andWebster, R. A. 1973. Reserpine rigidity and adrenergic neurones. Neuropharmacology 12:725–733.
Udenfriend, S., Zaltzman-Nirenberg, P., andNagatsu, T. 1965. Inhibitors of purified beef adrenal tyrosine hydroxylase. Biochem. Pharmacol. 14:837–845.
Janssen, P. A., Niemegeers, C. J., Schellekens, K. H. L., Dresse, A., Lenaerts, F. M., Pinchard, A., Schaper, W. K. A., Van Neuter, J. M., andVerbruggen, F. J. 1968. Pimozide, a chemically novel, highly potent and orally long-acting neuroleptic drug. I. The comparative pharmacology of pimozide, haloperidol and chlorpromasine. Arzneimittelforschung 18:261–279.
Pepeu, G. 1963. Effect of “tremorine” and some anti-Parkinson's disease drugs on acetylcholine in rat brain. Nature 200:895.
Baxter, C. F. 1970. The nature of GABA. Pages 289–353, inLajtha, A. (ed.), Handbook of Neurochemistry, Vol. 3, Plenum Press, New York.
Santini, M., andBerl, S. 1972. Effects of reserpine and monoamine oxidase inhibition on the levels of amino acids in sensory ganglia, sympathetic ganglia and spinal cord. Brain Res. 47:167–176.
Goldstein, M., Joh, T. H., andGarvey, T. Q. 1968. Kinetic studies of the enzymatic dopamine-β-hydroxylase reaction. Biochemistry 7:2724–2730.
Cools, A. R., andJanssen, H. J. 1976. γ-Aminobutyric acid: The essential mediator of behaviour triggered by neostriatally applied apomorphine and haloperidol. J. Pharm. Pharmacol. 28:70–74.
Anden, N. E., andBedard, P. 1971. Influence of cholinergic mechanisms on the function and turnover of brain dopamine. J. Pharm. Pharmacol. 23:460–463.
Ladinsky, H., Consolo, S., Bianchi, S., andJori, A. 1976. Increase in striatal acetylcholine by picrotoxin in the rat: Evidence for a GABAergic-dopaminergiccholinergic link. Brain Res. 108:351–361.
Crossman, A. R., Walker, R. J., andWoodruff, G. N. 1973. Picrotoxin antagonism of GABA inhibitory responses and synaptic inhibition in the rat substantia nigra. Br. J. Pharmacol. 49:696–698.
Dray, A., andGonye, T. J. 1975. Effects of caudate stimulation and microiontophoretically applied substances on neurones in the rat substantia nigra. J. Physiol. Lond. 246:88–89P.
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Roberts, P.J., Kapur, H. Neurochemical changes in rat striatum and substantia nigra following drug administration. Neurochem Res 2, 485–494 (1977). https://doi.org/10.1007/BF00966009
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DOI: https://doi.org/10.1007/BF00966009