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Molecular and biochemical features of poly (ADP-ribose) metabolism

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Abstract

In the past five years, poly(ADP-ribosyl)ation has developed greatly with the help of molecular biology and the improvement of biochemical techniques. In this article, we describe the physico-chemical properties of the enzymes responsible for the synthesis and degradation of poly(ADP-ribose), respectively poly(ADP-ribose) polymerase and poly(ADP-ribose) glycohydrolase. We then discuss the possible roles of this polymer in DNA repair and replication as well as in cellular differentiation and transformation. Finally, we put forward various hypotheses in order to better define the function of this polymer found only in eucaryotes. (Mol Cell Biochem122: 171–193, 1993)

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Abbreviations

3-AB:

3-Aminobenzamide

3-MBA:

3-Methoxybenzamide

AADH:

Amino Acid Dehydrogenase

CAT:

Chloramphenicol Acetyl Transferase

DHFR:

Dihydrofolate Reductase

DMS:

Dimethylsulfate

DMSO:

Dimethylsulfoxide

DNase:

Deoxyribonuclease

HMG:

High Mobility Group

kb:

Kilobase

kDa:

Kilodalton

LMG:

Low Mobility Group

MNNG:

Methylnitroso Nitroguanidine

MNU:

Methylnitrosourea

NAD:

Nicotinamide Adenine Dinucleotide

NLS:

Nuclear Localization System

NTP:

Nucleotide Triphosphate

pADPR:

Poly (ADP-ribose)

PARP:

Poly(ADP-ribose) Polymerase

PHA:

Phytohemaglutinin

PMA:

Phorbol Myristate Acetate

PRAMP:

Phosphoribosyl AMP

(PR)2AMP:

Diphosphoribosyl AMP

RNase:

Ribonuclease

SCE:

Sister Chromatid Exchange

TPA:

Tetradecanoyl Phorbol-13-Acetate

UV:

Ultra-Violet

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  1. Poly (ADP-ribose) Metabolism Laboratory, Molecular Endocrinology, CHUL Research Center, 2705 boul. Laurier, GIV 4G2, Ste-Foy, Québec, Canada

    Jean Lagueux & Guy G. Poirier

  2. Microfluorimétrie quantitative et pharmacocinétique cellulaire, Laboratoire de Chimie-Physique, Université de Perpignan, 66026, Perpignan, France

    Dominique Lautier

  3. Institut de Recherches cliniques de Montréal, 110 rue des Pins ouest, H2W 1R7, Montréal, Canada

    Jacques Thibodeau

  4. Medical Center, Duke University, 254 Jones Bldg Research Dr., 27710, Durham, North Carolina, USA

    Luc Ménard

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Lautier, D., Lagueux, J., Thibodeau, J. et al. Molecular and biochemical features of poly (ADP-ribose) metabolism. Mol Cell Biochem 122, 171–193 (1993). https://doi.org/10.1007/BF01076101

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