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Thymidine kinase, DNA synthesis and cancer

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Summary

A resume has been presented of some recent investigations which show that DNA synthesis can be initiated in many types of quiescent animal cells by external stimuli, by introducing a quiescent nucleus into the cytoplasm of a proliferating cell, or by a virus infection. The components of the DNA replication apparatus are described. It is shown that deoxyribonucleoside triphosphate pools increase substantially in animal cells at the time DNA synthesis is initiated due to the enhanced activities of enzymes functioning in nucleotide synthesis. Especially striking is the increase of thymidine kinase activity, indicating that this enzyme may be a useful marker of the shift from the quiescent to the replicative state. The thymidine kinase isozymes of vertebrate cells have been characterized. Thymidine kinase F, which is found principally in the cytosol, is the isozyme that increases when G1(Go) phase cells are stimulated or infected with oncogenic viruses. Chick cytosol thymidine kinase F can also be reactivated by introducing differentiated chick erythrocyte nuclei into the cytoplasm of enzyme-deficient LM(TK−) mouse cells. Furthermore, herpesviruses code for distinctive, virus-specific thymidine kinase isozymes, so that another way to transform thymidine kinase-deficient LM(TK−) cells to kinase-positive cells is by infecting them with UV-irradiated herpes simplex viruses. The experiments on the activation of DNA synthesis and thymidine kinase F activity have been discussed in the context of the proliferative activityin vivo and the immortalization in culture of neoplastic cells. These experiments suggest that genes determining cell cycle proteins are readily accessible to transcription and translation in essentially all nucleated cells. The tendency of transformed cells to become multinucleated after cytochaliasin B treatment also suggests that one important difference between malignant cells and most normal cells may be the ability of malignant cells to ‘stockpile’ the proteins (and/or their messenger RNAs) of the DNA replicative apparatus and to maintain the ‘stockpiles’ in progeny cells.

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References

  1. R. J. Huebner and G. J. Todaro, Proc. Nat. Acad. Sci. U.S.A. 64, 1087 (1969).

    Google Scholar 

  2. N. G. Anderson and J. H. Coggin, Jr., Proc. First Conferences and Workshop on Embryonic and Fetal Antigens in Cancer. Ed. by N. G. Anderson and J. H. Coggin, Jr. pp. 7–37. Available from the National Technical Information Service, U.S. Department of Commerce, Springfield, Va. 22151 (1971).

    Google Scholar 

  3. S. Weinhouse, in ‘Control Processes in Neoplasia’, ed. by M. A. Mehlman and R. W. Hanson, Academic Press Inc., New York and London, pp. 1–30 (1974).

    Google Scholar 

  4. S. Weinhouse and T. Ono, Isozymes and Enzyme Regulation in Cancer, University Park Press, Baltimore (1972).

    Google Scholar 

  5. J. I. Goodman and V. R. Potter, Proc. First Conference and Workshop on Embryonic and Fetal Antigens in Cancer. Ed. by N. G. Anderson and J. H. Coggin, Jr. pp. 39–54. Available from the National Technical Information Service, U.S. Department of Commerce, Springfield, Va. 22151 (1971).

    Google Scholar 

  6. H. Holtzer, H. Weintraub, R. Mayne, and B. Mochan, Current Topics in Developmental Biology 7, 229–256 Ed. by A. A. Moscona, Academic Press Inc., New York and London (1972).

    Google Scholar 

  7. J. S. Sobel, Science 153, 1387–1389 (1966).

    Google Scholar 

  8. P. R. Harrison, D. Conkie, and J. Paul, The Cell Cycle in Development and Differentiation. Ed. by M. Balls and F. S. Billet, Cambridge University Press, London pp. 341–364 (1973).

    Google Scholar 

  9. J. J. Trentin, in ‘Regulation of Hematopoiesis’, ed. by A. S. Gordon, Vol. 1, pp. 161–186, Appleton-Century-Crofts, New York (1971).

    Google Scholar 

  10. N. R. Ling, ‘Lymphocyte Stimulation’, North-Holland Publishers, Amsterdam (1968).

    Google Scholar 

  11. H. Harris, ‘Nucleus and Cytoplasm’, Clarendon Press, Oxford (1970).

    Google Scholar 

  12. T. Ege, S. A. Carlsson, and N. R. Ringertz, Exptl. Cell Res. 69, 472–477 (1972).

    Google Scholar 

  13. R. Appels, L. Bolund, S. Goto, and N. R. Ringertz, Exptl. Cell Res. 85, 182–190 (1974).

    Google Scholar 

  14. S. A. Carlsson, R. E. Savage, and N. R. Ringertz, Nature 228, 869–871 (1970).

    Google Scholar 

  15. A. M. Kernell, L. Bolund, and N. R. Ringertz, Exptl. Cell Res. 65, 1–6 (1971).

    Google Scholar 

  16. C. O. Jacobson, Exptl. Cell Res. 53, 316–318 (1969).

    Google Scholar 

  17. J. G. Gurdon, Proc. Nat. Acad. Sci. U.S.A. 58, 545–552 (1967).

    Google Scholar 

  18. R. Dulbecco, L. H. Hartwell, and M. Vogt, Proc. Nat. Acad. Sci. U.S.A. 53, 403–410 (1965).

    Google Scholar 

  19. E. Wincour, Adv. Virus Research 14, 153–200 (1969).

    Google Scholar 

  20. S. Kit, R. A. de Torres, D. R. Dubbs, and M. L. Salvi, J. Virology 1, 738–746 (1967).

    Google Scholar 

  21. J. M. Lehman and V. Defendi, J. Virology 6, 738–749 (1970).

    Google Scholar 

  22. R. Weil and J. Kara, Proc. Nat. Acad. Sci. U.S.A. 67, 1011–1017 (1970).

    Google Scholar 

  23. A. J. Levine, Proc. Nat. Acad. Sci. U.S.A. 68, 717–720 (1971).

    Google Scholar 

  24. S. Kit, D. R. Dubbs, and K. Somers, Ciba Foundation Symposium on the Strategy of the Viral Genome. Ed. by G. E. W. Wolstenholme and M. O'Connor. Churchill Livingstone, London pp. 229–265 (1971).

    Google Scholar 

  25. L. B. Stone and K. K. Takemoto, J. Virology 6, 621–627 (1970).

    Google Scholar 

  26. L. Mallucci and J. Taylor-Papadimitriou, J. gen. Virol. 21, 391–398 (1973).

    Google Scholar 

  27. D. Yaffe and D. Gershon, Nature 215, 421–424 (1967).

    Google Scholar 

  28. H. H. Lee, M. E. Kaighn, and J. D. Ebert, Int. J. Cancer 3, 126–136 (1968).

    Google Scholar 

  29. T. Yamashita and H. Shimojo, Virology 38, 351–355 (1969).

    Google Scholar 

  30. S. C. St. Jeor, T. B. Albrecht, F. D. Funk, and F. Rapp, J. Virology 13, 353–362 (1974).

    Google Scholar 

  31. G. Miller, J. Inf. Diseases 130, 187–205 (1974).

    Google Scholar 

  32. Y. Akiyama, S. Kato, and N. Iwa, Bikens Journal 16, 177–179 (1973).

    Google Scholar 

  33. P. Gerber and B. H. Hoyer, Nature 231, 46–47 (1971).

    Google Scholar 

  34. L. F. Lee, J. Virology 10, 167–170 (1972).

    Google Scholar 

  35. A. Kornberg, ‘DNA Synthesis’, W. H. Freeman and Co., San Francisco (1974).

    Google Scholar 

  36. R. Schekman, A. Weiner, and A. Kornberg, Science 186, 987–993 (1974).

    Google Scholar 

  37. J. A. Fuchs and H. O. Karlstrom, Eur. J. Biochem. 32, 457–462 (1973).

    Google Scholar 

  38. R. Hand and I. Tamm, ‘Cell Cycle Controls’, ed. by G. M. Padillo, I. L. Cameron, and A. Zimmerman, Academic Press Inc., New York pp. 273–288 (1974).

    Google Scholar 

  39. G. A. Candelas, in ‘Cell Cycle Controls’, ed. by G. M. Padillo, I. L. Cameron, and A. Zimmerman, Academic Press Inc., New York pp. 61–76 (1974).

    Google Scholar 

  40. J. C. Houck, A. M. Attallah, and J. R. Lilly, Nature 245, 148–150 (1973).

    Google Scholar 

  41. D. S. O'Dell, FEBS Letters 26, 1–5 (1972).

    Google Scholar 

  42. Z. Darzynkiewicz, E. Chelmicka-Szorc, and B. G. W. Arnason, Exptl. Cell Res. 87, 333–345 (1974).

    Google Scholar 

  43. A. B. Pardee, Proc. Nat. Acad. Sci. U.S.A. 71, 1286–1290 (1974).

    Google Scholar 

  44. R. W. Holley and J. A. Kiernan, Proc. Nat. Acad. Sci. U.S.A. 60, 300–304 (1968).

    Google Scholar 

  45. R. W. Holley and J. A. Kiernan, Proc. Nat. Acad. Sci. U.S.A. 71, 2942–2945 (1974).

    Google Scholar 

  46. H. Eagle, G. E. Foley, H. Koprowski, H. Lazarus, E. M. Levine, and R. A. Adams, J. Exptl. Med. 131, 863–879 (1970).

    Google Scholar 

  47. J. Jainchill and G. J. Todaro, Exptl. Cell Res. 59, 137–146 (1970).

    Google Scholar 

  48. H. S. Smith, C. D. Scher, and G. J. Todaro, Virology 44, 359–370 (1971).

    Google Scholar 

  49. R. Dulbecco and W. Eckhart, Proc. Nat. Acad. Sci. U.S.A. 67, 1775–1781 (1970).

    Google Scholar 

  50. J. B. Griffiths, J. Cell Science 7, 575–585 (1970).

    Google Scholar 

  51. D. Gospodarowicz and J. S. Moran, Proc. Nat. Acad. Sci. U.S.A. 71, 4584–4588 (1974).

    Google Scholar 

  52. P. S. Rudland, D. Gospodarowicz, and W. Seifert, Nature 250, 741–743 (1974).

    Google Scholar 

  53. Y. Weinstein, D. A. Chambers, H. R. Bourne, and K. L. Melmon, Nature 251, 352–353 (1974).

    Google Scholar 

  54. H. M. Temin, J. Cell. Physiol. 78, 161–170 (1970).

    Google Scholar 

  55. B. J. Smith and N. M. Wigglesworth, J. Cell. Physiol. 82, 339–348 (1973).

    Google Scholar 

  56. K. G. Bjursell, P. A. Reichard, and K. L. Skoog, Eur. J. Biochem. 29, 348–353 (1972).

    Google Scholar 

  57. R. L. P. Adams, S. Berryman, and A. Thomson, Biochim. Biophys. Acta, 240, 455–462 (1971).

    Google Scholar 

  58. G. Bray and T. P. Brent, Biochim. Biophys. Acta, 269, 184–191 (1972).

    Google Scholar 

  59. L. Skoog and B. Nordenskjold, Eur. J. Biochem. 19, 81–89 (1971).

    Google Scholar 

  60. N. L. R. Bucher and N. J. Oakman, Biochim. Biophys. Acta, 186, 13–20 (1969).

    Google Scholar 

  61. U. Lindberg, B. A. Nordenskjold, P. Reichard, and L. Skoog, Cancer Res. 29, 1498–1506 (1969).

    Google Scholar 

  62. K. Wilms and W. Wilmanns, Klinische Wochenschrift 47, 39–42 (1969).

    Google Scholar 

  63. L. A. Loeb and S. S. Agarwal, Exptl. Cell Res. 66, 299–304 (1971).

    Google Scholar 

  64. G. Tyrsted, B. Munch-Petersen, and L. Cloos, Exptl. Cell Res. 77, 415–427 (1973).

    Google Scholar 

  65. L. Pegoraro and M. G. Bernengo, Exptl. Cell Res. 68, 283–290 (1971).

    Google Scholar 

  66. L. A. Loeb, J. L. Ewald, and S. S. Agarwal, Cancer Res. 30, 2514–2520 (1970).

    Google Scholar 

  67. G. C. F. Pedralinoy, S. Spadari, G. Ciarrocchi, A. M. Pedrini and A. Falaschi, Eur. J. Biochem. 39, 343–351 (1973).

    Google Scholar 

  68. A. Larrson, Eur. J. Biochem. 11, 113–121 (1969).

    Google Scholar 

  69. R. Labow, G. F. Maley, and F. Maley, Cancer Res. 29, 366–372 (1969).

    Google Scholar 

  70. H. A. Rolton and H. M. Keir, Biochem. J. 141, 211–217 (1974).

    Google Scholar 

  71. A. S. Gelbard, J. H. Kim, A. G. Perez, Biochim. Biophys. Acta, 182, 564–566 (1969).

    Google Scholar 

  72. S. A. Murphree, E. Stubblefield, and E. C. Moore, Exptl. Cell Res. 58, 118–124 (1969).

    Google Scholar 

  73. J. P. Whitlock, Jr., R. Kaufman, and R. Baserga, Cancer Res. 28, 2211–2216 (1968).

    Google Scholar 

  74. J. P. Durham and N. Galanti, J. Biol. Chem. 249, 1806–1813 (1974).

    Google Scholar 

  75. E. D. Mayfield, Jr., R. A. Liebelt, and E. Bresnick, Cancer Res. 27, 1652–1657 (1967).

    Google Scholar 

  76. H. Masui and L. D. Garren, J. Biol. Chem. 245, 2627–2632 (1970).

    Google Scholar 

  77. S. Kit and D. R. Dubbs, Enzyme Induction by Viruses, S. Karger, Basel (1969).

    Google Scholar 

  78. H. Madreiter, P. Kaden, and C. Mittermayer, Eur. J. Biochem. 18, 369–375 (1971).

    Google Scholar 

  79. S. Spadari and A. Weissbach, J. Mol. Biol. 86, 11–20 (1974).

    Google Scholar 

  80. G. H. Cohen, J. Virology 9, 408–418 (1972).

    Google Scholar 

  81. H. L. Gordon, Cancer Res. 29, 1350–1355 (1969).

    Google Scholar 

  82. S. Kit, L. J. Piekarski, D. R. Dubbs, R. A. de Torres, and M. Anken, J. Virology, 1, 10–15 (1967).

    Google Scholar 

  83. J. A. Boezi, L. F. Lee, R. W. Blakesley, M. Koenig and H. C. Towle, J. Virology 14, 1209–1219 (1974).

    Google Scholar 

  84. S. Kit, W.-C. Leung, and D. Trkula, ‘Control Processes in Neoplasia’, ed. by M. A. Mehlman and R. W. Hanson, Academic Press Inc., New York and London pp. 103–145 (1974).

    Google Scholar 

  85. R. Machovich and O. Greengard, Biochim. Biophys. Acta 286, 375–381 (1972).

    Google Scholar 

  86. K. M. Hwang, S. A. Murphree, and A. C. Sartorelli, Cancer Res. 33, 2149–2155 (1973).

    Google Scholar 

  87. J. S. Salser and M. E. Balis, Cancer Res. 33, 1889–1897 (1973).

    Google Scholar 

  88. S. Kit, W.-C. Leung, G. N. Jorgensen, D. Trkula, and D. R. Dubbs, Progress in Medical Virology (in press).

  89. S. Kit, D. R. Dubbs, L. J. Piekarski, and T. C. Hsu, Exptl. Cell Res. 31, 297–312 (1963).

    Google Scholar 

  90. S. Kit, D. R. Dubbs, and P. M. Frearson, Int. J. Cancer 1, 19–30 (1966).

    Google Scholar 

  91. D. R. Dubbs, S. Kit, R. A. de Torres, and M. Anken, J. Virology 1, 968–979 (1967).

    Google Scholar 

  92. J. Littlefield, Exptl. Cell Res. 41, 190–196 (1966).

    Google Scholar 

  93. R. Davidson and B. Ephrussi, Nature 205, 1170–1171 (1965).

    Google Scholar 

  94. E. K. Sell and R. S. Krooth, J. Cell. Physiol. 80, 453–462 (1972).

    Google Scholar 

  95. H. Harris, O. J. Miller, G. Klein, P. Worst, and T. Tachibana, Nature 223, 363–368 (1969).

    Google Scholar 

  96. M. C. Weiss and H. Green, Proc. Nat. Acad. Sci. U.S.A. 58, 1104–1111 (1967).

    Google Scholar 

  97. O. J. Miller, P. W. Allderdice, D. A. Miller, W. R. Breg, and B. R. Migeon, Science 173, 244–245 (1971).

    Google Scholar 

  98. J. K. McDougall, R. Kucherlapati, and F. H. Ruddle, Nature New Biol. 245, 172–175 (1973).

    Google Scholar 

  99. C. M. Croce, A. J. Girardi, and H. Koprowski, Proc. Nat. Acad. Sci. U.S.A. 70, 3617–3620 (1973).

    Google Scholar 

  100. K. V. Chace and D. H. Hall, J. Virology 12, 343–348 (1973).

    Google Scholar 

  101. S. Kit and Y. Minekawa, Cancer Res. 32, 2277–2288 (1972).

    Google Scholar 

  102. D. A. Clayton and R. L. Tepletz, J. Cell Science 10, 487–493 (1972).

    Google Scholar 

  103. A. J. Berk and D. A. Clayton, J. Biol. Chem. 248, 2722–2729 (1973).

    Google Scholar 

  104. B. Attardi and G. Attardi, Proc. Nat. Acad. Sci. U.S.A. 69, 2874–2878 (1972).

    Google Scholar 

  105. S. Kit, L. A. Kaplan, W.-C. Leung, and D. Trkula, Biochem. Biophys. Res. Commun. 49, 1561–1567 (1972).

    Google Scholar 

  106. S. Kit, W.-C. Leung, and L. A. Kaplan, Eur. J. Biochem. 39, 43–48 (1973).

    Google Scholar 

  107. S. Kit, W.-C. Leung, and D. Trkula, Biochem. Biophys. Res. Commun. 54, 455–461 (1973).

    Google Scholar 

  108. S. Kit, W.-C. Leung, and D. Trkula, Arch. Biochem. Biophys. 158, 503–513 (1973).

    Google Scholar 

  109. B. R. de Saint-Vincent and G. Buttin, Eur. J. Biochem. 37, 481–488 (1973).

    Google Scholar 

  110. L. Zeman and C. V. Lusena, FEBS Letters 40, 84–87 (1974).

    Google Scholar 

  111. D. C. Swinton and P. Hanawalt, J. Cell Biol. 54, 592–597 (1972).

    Google Scholar 

  112. S. J. Adelstein, C. Baldwin, and H. I. Kohn, Developmental Biol. 26, 537–546 (1971).

    Google Scholar 

  113. R. Adler and B. R. McAuslan, Cell 2, 113–117 (1974).

    Google Scholar 

  114. M. A. Stafford and O. W. Jones, Biochim. Biophys. Acta 277, 439–442 (1972).

    Google Scholar 

  115. S. Kit and W.-C. Leung, Biochem. Genetics 11, 231–247 (1974).

    Google Scholar 

  116. S. Kit and W.-C. Leung, J. Cell Biol. 61, 35–44 (1974).

    Google Scholar 

  117. S. Kit, W.-C. Leung, G. Jorgensen, D. Trkula, and D. R. Dubbs, J. gen. Virol. 24, 281–292 (1974).

    Google Scholar 

  118. S. Kit, W.-C. Leung, D. Trkula, D. R. Dubbs, and G. Jorgensen, Intervirology 2, 137–151 (1973/1974).

    Google Scholar 

  119. J. F. McDougall, J. gen. Virol. 12, 43–51 (1971).

    Google Scholar 

  120. K. Biron, C. M. Croce, and K. Raska, Abstracts of the 74th Annual Meeting of the American Society of Microbiology p. 252 (1974).

  121. S. Kit, W.-C. Leung, D. Trkula, and G. Jorgensen. Int. J. Cancer 13, 203–218 (1974).

    Google Scholar 

  122. S. Kit, G. N. Jorgensen, W.-C. Leung, D. Trkula, and D. R. Dubbs, Intervirology 2, 299–311 (1973/1974).

    Google Scholar 

  123. S. Kit, W.-C. Leung, G. N. Jorgensen, and D. R. Dubbs, Int. J. Cancer 14, 598–610 (1974).

    Google Scholar 

  124. A. T. Jamieson, G. A. Gentry, and J. H. Subak-Sharpe, J. gen. Virol. 24, 465–480 (1974).

    Google Scholar 

  125. A. T. Jamieson and J. H. Subak-Sharpe, J. gen. Virol. 24, 481–492 (1974).

    Google Scholar 

  126. S. Kit, W.-C. Leung, D. Trkula, and D. R. Dubbs (unpublished experiments).

  127. G. M. Cooper, Proc. Nat. Acad. Sci. U.S.A. 70, 3788–3792 (1973).

    Google Scholar 

  128. G. M. Aron, P. A. Schaffer, R. J. Courtney, M. Benyesh-Melnick, and S. Kit, Intervirology 1, 96–109 (1973).

    Google Scholar 

  129. B. R. McAuslan, Virology 20, 162–168 (1963).

    Google Scholar 

  130. B. Garfinkle and B. R. McAuslan, Biochem. Biophys. Res. Commun. 58, 822–829 (1974).

    Google Scholar 

  131. J. R. Johnson and D. H. Hall, J. Virology 13, 666–676 (1974).

    Google Scholar 

  132. W. Munyon, E. Kraiselburd, D. Davis, and J. Mann, J. Virology 7, 813–820 (1971).

    Google Scholar 

  133. D. B. Davis, W. Munyon, R. Buchsbaum, and R. Chawda, J. Virology 13, 140–145 (1974).

    Google Scholar 

  134. S.-S. Lin and W. Munyon, J. Virology 14, 1199–1208 (1974).

    Google Scholar 

  135. B. Garfinkle and B. R. McAuslan, Proc. Nat. Acad. Sci. U.S.A. 71, 220–224 (1974).

    Google Scholar 

  136. B. Hampar, J. G. Derge, L. M. Martos, and J. L. Walker, Proc. Nat. Acad. Sci. U.S.A. 69, 78–82 (1972).

    Google Scholar 

  137. B. M. Reedman and G. Klein, Int. J. Cancer 11, 499–520 (1973).

    Google Scholar 

  138. S. Kit, W.-C. Leung, G. Jorgensen, D. Trkula, and D. R. Dubbs, J. Cell Biol. 63, 505–514 (1974).

    Google Scholar 

  139. S. Kit, W.-C. Leung, D. Trkula, and D. R. Dubbs, Archives Biochem. Biophys. 169, 66–76 (1975).

    Google Scholar 

  140. W.-C. Leung, T. R. Chen, D. R. Dubbs, and S. Kit, Expl. Cell Research 95, 320–326 (1975).

    Google Scholar 

  141. W. C. Lawrence, J. Virology 7, 736–748 (1971).

    Google Scholar 

  142. J. Pages, S. Manteuil, D. Stehelin, M. Fiszman, M. Marz, and M. Girard, J. Virology 12, 99–107 (1973).

    Google Scholar 

  143. G. Magnusson, J. Virology 12, 609–615 (1973).

    Google Scholar 

  144. S. Murphree, E. C. Moore, and P. T. Beall, Cancer Res. 28, 860–863 (1968).

    Google Scholar 

  145. N. C. Brown and P. Reichard, J. Mol. Biol. 46, 39–55 (1969).

    Google Scholar 

  146. P. G. W. Plageman and J. Erbe, J. Cell. Physiol. 83, 321–336 (1974).

    Google Scholar 

  147. B. Pessac and G. Calothy, Science 185, 709–710 (1974).

    Google Scholar 

  148. J. Ross, J. Gielen, S. Packman, Y. Ikawa, and P. Leder, J. Mol. Biol. 87, 697–714 (1974).

    Google Scholar 

  149. W. Ostertag, H. Melderis, G. Steinheider, N. Kluge, and S. Dube, Nature New Biol. 239, 231–234 (1972).

    Google Scholar 

  150. C. Friend, W. Scher, J. G. Holland, and T. Sato, Proc. Nat. Acad. Sci. U.S.A. 68, 378–382 (1971).

    Google Scholar 

  151. S. Gordon and Z. Cohn, J. Exptl. Med. 133, 321–338 (1971).

    Google Scholar 

  152. J. H. Postlethwait and H. A. Schneiderman, Ann. Rev. Genetics 7, 381–433 (1973).

    Google Scholar 

  153. C. F. Graham, in ‘The Cell Cycle in Development and Differentiation’, ed. by M. Balls and F. S. Billet, Cambridge University Press, London pp. 293–310 (1973).

    Google Scholar 

  154. V. Defendi and M. G. P. Stoker, Nature New Biol. 242, 24–26 (1973).

    Google Scholar 

  155. M. A. C. Ridler and G. F. Smith, J. Cell Science 3, 595–602 (1968).

    Google Scholar 

  156. W. E. Wright and L. Hayflick, Exptl. Cell Res. 74, 187–194 (1972).

    Google Scholar 

  157. F. Kelly and J. Sambrook, Nature New Biol. 242, 217–219 (1973).

    Google Scholar 

  158. A. Hirano and T. Kurimura, Exptl. Cell Res. 89, 111–120 (1974).

    Google Scholar 

  159. R. B. Carroll, L. Hager, and R. Dulbecco, Proc. Nat. Acad. Sci. U.S.A. 71, 3754–3757 (1974).

    Google Scholar 

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  1. Division of Biochemical Virology, Baylor College of Medicine, 77025, Houston, Texas, USA

    Saul Kit

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Kit, S. Thymidine kinase, DNA synthesis and cancer. Mol Cell Biochem 11, 161–182 (1976). https://doi.org/10.1007/BF01744997

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