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Granulocyte-macrophage colony-stimulating factor (GM-CSF) and opsonization synergistically enhance leukotriene B4 (LTB4) synthesis induced by phagocytosis in human neutrophils

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Abstract

Normal human blood neutrophils were studied for their capacity to synthesize leukotriene B4 (LTB4) and its Ω-oxidized metabolites after phagocytosis of zymosan. Phagocytosis of serum-opsonized particles led to a higher release of LTs than did unopsonized zymosan. The most stricking effect of phagocytosis was observed when neutrophils were primed with granulocyte-macrophage colony-stimulating factor (GM-CSF): opsonization and GM-CSF synergistically increased LTB4 synthesis by neutrophils.

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Poubelle, P.E., Bourgoin, S., Naccache, P.H. et al. Granulocyte-macrophage colony-stimulating factor (GM-CSF) and opsonization synergistically enhance leukotriene B4 (LTB4) synthesis induced by phagocytosis in human neutrophils. Agents and Actions 27, 388–390 (1989). https://doi.org/10.1007/BF01972830

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