Abstract
A pharmacokinetic interpretation of the effects and side-effects of acidic non-steroid anti-inflammatory drugs is presented. It is based on the general principles of drug action and leads to the conclusion that aspirin-like drugs should specifically accumulate and exert pharmacological activity in inflammed tissue, stomach and kidney. Therefore the common effects and side-effects of these drugs may result from unspecific effects in these compartments and might not necessarily be due to specific, i.e., receptor mediated action(s).
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Brune, K. How aspirin might work: A pharmacokinetic approach. Agents and Actions 43, 218–220 (1994). https://doi.org/10.1007/BF01986692
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DOI: https://doi.org/10.1007/BF01986692