Abstract
Functional and specific histamine H2 receptors were characterized in human peripheral monocytes and in U-937 cells, before and after retinoid acid-induced differentiation into monocyte/macrophage-like cells. The relative potencies of histamine and the H1, H2 receptor agonists and antagonists studied are remarkably similar in U-937 cells and U-937 monocytes. There is no change in histamine concentration and activity of the enzymes forming and degrading histamine during monocytic-like differentiation. The results raise the possibility that histamine H2 receptors might be involved in pathophysiological regulations (proliferation/differentiation and biological function) of normal and leukemic monocytes.
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Gespach, C., Courillon-Mallet, A., Launay, J.M. et al. Histamine H2 receptor activity and histamine metabolism in human U-937 monocyte-like cells and human peripheral monocytes. Agents and Actions 18, 124–128 (1986). https://doi.org/10.1007/BF01988001
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DOI: https://doi.org/10.1007/BF01988001