Abstract
The effect of isradipine, a dihydropyridine calcium antagonist, on cocaine intravenous self-administration in rats was investigated. Administration of (±)isradipine (1.25–5 mg/kg SC) 2 h before the cocaine self-administration session induced a significant and dose-dependent increase in the number of coacine injections with respect to basal values. This effect was sterospecific, with the (+) form of isradipine being active, while the (−) stereoisomer was ineffective. These results suggest that isradipine antagonizes the rewarding properties of cocaine, possibly by inhibiting those dopaminergic systems related to reward mechanisms. These results further indicate a possible use of isradipine, or structurally similar compounds, in the treatment of cocaine related disorders.
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Martellotta, M.C., Kuzmin, A., Muglia, P. et al. Effects of the calcium antagonist isradipine on cocaine intravenous self-administration in rats. Psychopharmacology 113, 378–380 (1994). https://doi.org/10.1007/BF02245212
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DOI: https://doi.org/10.1007/BF02245212