Abstract
Cyclic nucleotides are important second messengers that mediate a number of cellular responses to external signals. Cyclic nucleotide phosphodiesterases play a role in signal transduction by regulating the cellular concentrations of these messengers. Here, we have applied Southern analyses of somatic cell hybrid lines and of recombinant inbred (RI) mouse strains as well as fluorescence chromosomal in situ hybridization (FISH) to chromosomally localize five cAMP-specific nucleotide phosphodiesterase genes in human and mouse. GenesDPDE1, DPDE2, DPDE3, andDPDE4 that share sequence homology with theDrosophila dunce gene were assigned to human chromosomes 19 (DPDE1 andDPDE2), 5q12 (DPDE3), and 1p31 (DPDE4) and to mouse chromosomes 8, 9, 13, and 4, respectively. The high-affinity cAMP-specific phosphodiesterase gene (HCP1) was mapped to human chromosome 8q13-q22. Since these genes are potential candidates for involvement in psychiatric or behavioral disorders, knowledge of their chromosomal localizations will facilitate the discovery of their association with disease genes as they are being mapped by linkage studies.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Literature Cited
Bolger, G., Michaeli, T., Martins, T., St. John, T., Steiner, B., Rodgers, L., Riggs, M., Wigler, M., and Ferguson, K. (1993).Mol. Cell. Biol. 13:6558–6571.
Beavo, J.A., and Reifsnyder, D.H. (1990).Trends Pharm. Sci. 11:150–155.
Michaeli, T., Bloom, T., Loughney, K., Ferguson, K., Riggs, M., Rodgers, L., Beavo, J.A., and Wigler, M. (1993).J. Biol. Chem. 268:12925–12932.
Davis, R.L., and Dauwalder, B. (1991).Trends Genet. 7:224–229.
Colicelli, J.C., Nicolette, C., Birchmeier, C., Rodgers, L., Riggs, M., and Wigler, M. (1991).Proc. Natl. Acad. Sci. U.S.A. 88:2913–2917.
Colicelli, J.C., Birchmeier, C., Michaeli, T., O'Neill, K., Riggs, M., and Wigler, M. (1989).Proc. Natl. Acad. Sci. U.S.A. 86:3599–3603.
Francke, U., Yang-Feng, T.L., Brissenden, J.E., and Ulrich, A. (1986).CSH Symp. Quant. Biol. 51:855–866.
Yang-Feng, T.L., DeGennaro, L.J., and Francke, U. (1986).Proc. Natl. Acad. Sci. U.S.A. 83:8679–8683.
Milatovich, A., Travis, A., Grosschedl, R., and Francke, U. (1991).Genomics 11:1040–1048.
George, D.L., and Francke, U. (1977).Somat. Cell Genet. 3:629–638.
Francke, U., and Pellegrino, M.A. (1977).Proc. Natl. Acad. Sci. U.S.A. 74:1147–1151 and 5776 (correction).
Wagner, M.J., Ge, Y., Siciliano, M., and Wells, D.E. (1991).Genomics 10:114–125.
Yunis, J.J. (1976).Science 191:1268–1270.
George, D.L., and Francke, U. (1980).Cytogenet. Cell Genet. 28:217–226.
Silver, J. (1985).J. Hered. 76:436–440.
Ceci, J.D. (1993).Mamm. Genome 4:S121-S135.
Copeland, N.G., Jenkins, N.A., Gilbert, D.J., Eppig, J.T., Maltais, L.J., Miller, J.C., Dietrich, W.F., Weaver, A., Lincoln, S.E., Steen, R.G., Stein, L.D., Nadeau, J.H., and Lander, E.S. (1993).Science 262:57–66.
Mattei, M.G., Simon-Chazottes, D., Hirai, S.-I., Ryseck, R.-P., Galcheva-Gargova, Z., Guenet, J.L., Mattei, J.F., Bravo, R., and Yaniv, M. (1990).Oncogene 5:151–156.
Trask, B., Fertitta, A., Christensen, M., Youngblom, J., Bergmann, A., Copeland, A., de Jong, P., Mohrenweiser, H., Olsen, A., Carrano, A., and Tynan, K. (1993).Genomics 15:133–145.
Nimmo, E., Padua, R.-A., Hughes, D., Brook, J.D., Williamson, R., and Johnson, K.J. (1989).Hum. Genet. 81:382–384.
Kingsley, D.M. (1993).Mamm. Genome 4:S136-S153.
Justice, M.J., and Stephenson, D.A. (1993).Mamm. Genome 4:S192-S202.
Wirth, B., Voosen, B., Röhrig, D., Knapp, M., Piechaczek, B., Rudnik-Schöneborn, S., and Zerres, K. (1993).Genomics 15:113–118.
Bassett, A.S., McGillivray, B.C., Jones, B.D., and Pantzar, J.T. (1988).Lancet 1:799–801.
McGillivray, B.C., Bassett, A.S., Langlois, S., Pantzar, T., and Wood, S. (1990).Am. J. Med. Genet. 35:10–13.
Sherrington, R., Brynjolfsson, J., Petursson, H., Potter, M., Dudleston, K., Barraclough, B., Wasmuth, J., Dobbs, M., and Gurling, H. (1988).Nature 336:164–167.
McGuffin, P., Sargeant, M., Hetti, G., Tidmarsh, S., Whatley, S., and Marchbanks, R.M. (1990).Am. J. Hum. Genet. 47:524–535.
Abbott, C.M., Blank, R., Eppig, J.T., Fiedorek, Jr. F.T., Frankel, W., Friedman, J.M., Huppi, K.E., Jackson, I., Steel, K., Mock, B.A., Stoye, J., and Seman, R.W. (1993).Mamm. Genome 4:S58-S71.
Hellsten, E., Vesa, J., Speer, M.C., Makela, T.P., Jarvela, I., Alitalo, K., Ott, J., and Peltonen, L. (1993).Genomics 16:720–725.
Pritchard, M.A., Baker, E., Callen, D.F., Sutherland, G.R., and Wilks, A.F. (1992).Mamm. Genome 3:36–38.
Baumann, H., Held, W.A., and Berger, F.G. (1984).J. Biol. Chem. 259:566–573.
Taylor, B.A. (1989). Recombinant inbred strains. InGenetic Variants and Strains of the Laboratory Mouse, 2nd ed., (eds.) Lyon, M.F., and Searle, A.G. (Oxford University Press, Oxford), pp. 773–796.
Frankel, W.N., Stoye, J.P., Taylor, B.A., and Coffin, J.M. (1989).J. Virol. 63:3810–3821.
Lee, B.K., and Eicher, E.M. (1990).J. Virol. 64:4568–4572.
Rohdewohld, H., and Gruss, P. (1992).Mamm. Genome 3:119–121.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Milatovich, A., Bolger, G., Michaeli, T. et al. Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse. Somat Cell Mol Genet 20, 75–86 (1994). https://doi.org/10.1007/BF02290677
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02290677