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VIP: Molecular biology and neurobiological function

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Abstract

In the mammalian brain, a major regulatory peptide is vasoactive intestinal peptide (VIP). This 28 amino acid peptide, originally isolated from the porcine duodenum, was later found in the central and peripheral nervous systems and in endocrine cells, where it exhibits neurotransmitter and hormonal roles. Increasing evidence points to VIP’s importance as a mediator or a modulator of several basic functions. Thus, VIP is a major factor in brain activity, neuroendocrine functions, cardiac activity, respiration, digestion, and sexual potency. In view of this peptide’s importance, the mechanisms controlling its production and the pathways regulating its functions have been reviewed. VIP is a member of a peptide family, including peptides such as glucagon, secretin, and growth hormone releasing hormone. These peptides may have evolved by exon duplication coupled with gene duplication. The human VIP gene contains seven exons, each encoding a distinct functional domain on the protein precursor or the mRNA. VIP gene transcripts are mainly found in neurons or neuron-related cells. VIP gene expression is regulated by neuronal and endocrine signals that contribute to its developmental control. VIP exerts its function via receptor-mediated systems, activating signal transduction pathways, including cAMP. It can act as a neurotransmitter, neuromodulator, and a secretagog. As a growth and developmental regulator, VIP may have a crucial effect as a neuronal survival factor. We shall proceed from the gene to its multiple functions.

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References

  • Abe H., Engler D., Molitch M. E., Bollinger-Gruber J., and Reichlin S. (1985) Vasoactive intestinal peptide is a physiological mediator of prolactin release in the rat.Endocrinology 116, 1383–1390.

    PubMed  CAS  Google Scholar 

  • Agoston D. V., Borroni E., and Richardson P. J. (1988a) Cholinergic surface antigen chol-1 is present in a subclass of VIP-containing rat cortical synaptosomes.J. Neurochem. 50, 1659–1662.

    PubMed  CAS  Google Scholar 

  • Agoston D. V., Conlon J. M., and Whittaker, V. P. (1988b) Selective depletion of the acetylcholine and vasoactive intestinal polypeptide of the guinea-pig myenteric plexus by differential mobilization of distinct transmitter pools.Exp. Brain Res. 72, 535–542.

    PubMed  CAS  Google Scholar 

  • Agoston D. V. and Lisziewicz J. (1989) Calcium uptake and protein phosphorylation in myenteric neurons, like, the release of vasoactive intestinal polypeptide and acetylcholine, are frequency dependent.J. Neurochem. 52, 1637–1640.

    PubMed  CAS  Google Scholar 

  • Agoston D. V. and Whittaker V. P. (1989) Characterization, by size, density, osmotic fragility, and immunoaffinity, of acetylcholine- and vasoactive intestinal polypeptide-containing storage particles from myenteric neurones of the guinea-pig.J. Neurochem. 52, 1474–1480.

    PubMed  CAS  Google Scholar 

  • Ahren B. and Hedner P. (1989) Effects of VIP and helodermin on thyroid hormone secretion in the mouse.Neuropeptides 13, 59–64.

    PubMed  CAS  Google Scholar 

  • Albers H. E., Ninamitani N., Stopa E., and Ferris C. F. (1987) Light selectivity alters vasoactive intestinal peptide and peptide histidine isoleucine immunoreactivity within the rat suprachiasmatic nucleus.Brain Res. 437, 189–192.

    PubMed  CAS  Google Scholar 

  • Allen J., Hansen V., Maigaard S., Andersson K. E., and Forman A. (1988) Effects of some neurotransmitters and prostanoids on isolated human intracervical arteries.Am. J. Obstet. Gynecol. 158, 637–641.

    PubMed  CAS  Google Scholar 

  • Allen J. M., Hoyle N. R., Yeats J. C., Ghatei M. A., Thomas D. G., and Bloom S. R. (1985) Neuropeptides in neurological tumors.J. Neuro-Oncol. 3, 197–202.

    CAS  Google Scholar 

  • Amara S. G., Jones V., Rosenfeld M. G., Ong E. S., and Evans R.M. (1982) Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products.Nature 298, 240–244.

    PubMed  CAS  Google Scholar 

  • Anteunis A., Astesano A., Portha B., Hejblum G., and Rosselin G. (1989) Ultrastructural analysis of VIP internalization in rat beta- and acinar cells in situ.Am. J. Physiol. 256, G689–697.

    PubMed  CAS  Google Scholar 

  • Arey, B. J. and Freeman, M. E. (1989) Hypothalamic factors involved in the endogenous stimulatory rhythm regulating prolactin secretion.Endocrinology 124, 878–883.

    PubMed  CAS  Google Scholar 

  • Avidor R., Eilam R., Malach R., and Gozes I. 91989) VIP-mRNA is increased in hypertensive rats.Brain Res., in press.

  • Audigier S., Barberis C., and Jard S. (1986) Vasoactive intestinal polypeptide increases inositol phospholipid breakdown in the rat superior cervical ganglion.Brain Res. 376, 363–367.

    PubMed  CAS  Google Scholar 

  • Baldino F., Jr., Fitzpatrick-McElligot S., O’Kane T. M., and Gozes I. (1988) Hormonal regulation of somatostatin messenger RNA.Synapse 2, 317–325.

    PubMed  CAS  Google Scholar 

  • Baldino F., Jr., Fitzpatrick-McElligott, S., Gozes I., and Card J. P. (1989) Localization of VIP and PHI-27 messenger RNA in rat thalamic and cortical neurons.J. Molec. Neurosci., in press.

  • Barbezat G. O. and Grossman M. I. (1971) Intestinal secretion: Stimulation by peptides.Science 174, 422, 423.

    PubMed  CAS  Google Scholar 

  • Bardrum B., Ottesen B., Fahrenkrug J., and Fuchs A. R. (1988) Release of oxytocin and vasopressin by intracerebroventricular vasoactive intestinal peptide.Endocrinology 123, 2249–2254.

    PubMed  CAS  Google Scholar 

  • Bataille D., Talbot J. N., Milhaud G., Mutt V., and Rosselin G. (1981) Effect of vasoactive intestinal peptide (VIP) on prolactin secretion in man.CR Seaces Acad. Sci. (III) 292, 511–513.

    CAS  Google Scholar 

  • Beinfeld M. C., Korchak D. M., Roth B. L., and O’Donohue T. L. (1984) The distribution and chromatographic characterization of PHI (peptide histidine isoleucine amide)-27-like peptides in rat and porcine brain.J. Neurosci. 4, 2681–2688.

    PubMed  CAS  Google Scholar 

  • Belai A., Lincoln J., Milner P., and Burnstock G. (1988) Progressive changes in adrenergic, serotonergic, and peptidergic nerves in proximal colon of streptozotocin-diabetic rats.Gastroenterology 9, 1234–1241.

    Google Scholar 

  • Bell G. I. (1986) The glucagon superfamily: precursor structure and gene organization.Peptides 7, 27–36.

    PubMed  CAS  Google Scholar 

  • Bell G. I., Sanchez-Pescador R., Laybourn P. J., and Najarian R. C. (1983) Exon duplication and divergence in the human preproglucagon gene.Nature 304, 368–371.

    PubMed  CAS  Google Scholar 

  • Bergman Y., Rice D., Grosschedl R., and Baltimore D. (1984)Proc. Natl. Acad. Sci. USA 81, 7041–7045.

    PubMed  CAS  Google Scholar 

  • Besson J., Rotsztejn W., Labourthe M., Epelbaum J., Beaudet A., Kordon C., and Rosselin G. (1979) Vasoactive intestinal peptide (VIP): brain distribution, subcellular localization and effect of deafferentation of the hypothalamus in male rats.Brain Research 165, 79–85.

    PubMed  CAS  Google Scholar 

  • Birnstiel M. L., Busslinger M., and Strub K. (1985) Transcription termination and 3′ processing: The end is in site!Cell 41, 349–359.

    PubMed  CAS  Google Scholar 

  • Bissonnette B. M., Collen M. J., Adachi H., Jensen R. T., and Gardner J. D. (1984) Receptors for vasoactive intestinal peptide and secretin on rat pancreatic acini.Am. J. Physiol. 246, G710-G717.

    PubMed  CAS  Google Scholar 

  • Bloom S. R., Christofides N. D., Delamarter J., Buell G., Kawashima E., and Polak J.M. (1983) Diarrhoea in vipoma patients associated with cosecretion of a second active peptide (peptide hist-idine isoleucine) explained by a single coding gene.Lancet 2, 1163–1165.

    PubMed  CAS  Google Scholar 

  • Bluet-Pajot M.-T., Mounier F., Leonard J.-F., Kordon C., and Durand D. (1987) Vasoactive intestinal peptide induces a transient release of growth hormone in the rat.Peptides 8, 35–38.

    PubMed  CAS  Google Scholar 

  • Bodner M., Fridkin M., and Gozes I. (1985) VIP and PHM-27 sequences are located on two adjacent exons in the human genome.Proc. Natl. Acad. Sci. USA 82, 3548–3551.

    PubMed  CAS  Google Scholar 

  • Boissard C., Marie J. C., Hejblum G., Gespach C., and Rosselin G. (1986) Vasoactive intestinal peptide receptor regulation and reversible desensitization in human colonic carcinoma cells in culture.Cancer Res. 46, 4406–4413.

    PubMed  CAS  Google Scholar 

  • Borgundvaag B. and George S. R. (1988) Estrogen regulation of rat anterior pituitary adenylate cyclase.Mol. Cell Endocrinol. 59, 35–45.

    PubMed  CAS  Google Scholar 

  • Bosler O. and Beaudet A. (1985) VIP neurons as prime synaptic targets for serotonin afferents in rat suprachiasmatic nucleus: A combined radioautographic and immunocytochemical study.J. Neurocytol. 14, 749–763.

    PubMed  CAS  Google Scholar 

  • Bowen B., Steinberg J., Laemmli U. K., and Weintroub H. (1980) The detection of DNA binding proteins by protein blotting.Nuc. Acid Res. 8, 1–20.

    CAS  Google Scholar 

  • Brar A. K., Fink G., Maletti M., and Rostene W. (1985) Vasoactive intestinal peptide in rat hypophysial portal blood: Effects of electrical stimulation of various brain areas, the oestrous cycle and anesthetics.J. Endocrinol. 106, 275–280.

    PubMed  CAS  Google Scholar 

  • Brayden J. E. and Conway M. A. (1988) Neuropeptide Y and vasoactive intestinal polypeptide in cerebral arteries of the rat: Relationships between innervation pattern and mechanical response.Regul. Pept. 22, 253–265.

    PubMed  CAS  Google Scholar 

  • Brenneman D. E., Eiden L. E., and Siegel R. E. (1985) Neurotrophic action of VIP on spinal cord cultures.Peptides 6 (suppl. 2), 35–39.

    PubMed  CAS  Google Scholar 

  • Brenneman D. E. and Eiden L. E. (1986) Vasoactive intestinal peptide and electrical activity influence neuronal survival.Proc. Natl. Acad. Sci. USA 83, 1159–1162.

    PubMed  CAS  Google Scholar 

  • Brenneman D. E. and Foster G. A. (1987a) Structural specificity of peptides influencing neuronal survival during development.Peptides 8, 687–694.

    PubMed  CAS  Google Scholar 

  • Brenneman D. E., Neale E. A., Foster G. A., d’Autremont S., and Westbrook G. L. (1987b) Nonneuronal cells mediate neurotrophic action of vasoactive intestinal peptide.J. Cell Biol. 104, 1603–1610.

    PubMed  CAS  Google Scholar 

  • Brenneman D. E. (1988a) Two mechanisms may contribute to the neuronal survival-promoting action of VIP: Neurotrophic factor releasing activity and glial mitogenesis.Soc. Neurosci. Abstr. 14, 254.

    Google Scholar 

  • Brenneman D. E., Buzy J. M., Ruff M. R., and Pert C. B. (1988b) Peptide T sequences prevent neuronal cell death produced by the envelope protein (gp120) of the human immunodeficiency virus.Drug Dev. Res. 15, 361–369.

    CAS  Google Scholar 

  • Brenneman D. E., Westbrook G., Fitzgerald S. P., Ennist D. L., Elkins K. L., Ruff M., and Pert C. B. (1988c) Neuronal cell killing by the envelope protein of HIV and its prevention by vasoactive intestinal peptide.Nature 335, 639–642.

    PubMed  CAS  Google Scholar 

  • Burnstock G., Mirsky R., and Belai A. (1988) Reversal of nerve damage in streptozotocin-diabetic rats by acute application of insulin in vitro.Clin. Science 75, 629–635.

    CAS  Google Scholar 

  • Buscher M., Rahmsdorpf H. J., Litfin M., Karin M., and Herrlich P. (1988) Activation pathways converge to the same enhancer element.Oncogene 3, 301–311.

    PubMed  CAS  Google Scholar 

  • Carati C. J., Creed K. E., and Keogh E. J. (1988) Vascular changes during penile erection in the dog.J. Physiol. 400, 75–88.

    PubMed  CAS  Google Scholar 

  • Card J. P. and Moore R. Y. (1982) Ventral lateral geniculate nucleus efferents to the rat suprachiasmatic nucleus exhibit avian pancreatic polypeptide-like immunoreactivity.Comp. Neurol. 206, 390–396.

    CAS  Google Scholar 

  • Card J. P., Fitzpatrick-McElligott S., Gozes I., and Baldino F., Jr. (1988) Localization of vasopressin-, vasoactive intestinal polypeptide-, peptide histidine isoleucine- and somatostatin-mRNA in rat suprachiasmatic nucleus.Cell Tissue Res. 252, 307–315.

    PubMed  CAS  Google Scholar 

  • Carmeliet P. and Denef C. (1988) Immunocytochemical and pharmacological evidence for an intrinsic cholinomimetic system modulating prolactin and growth hormone release in rat pituitary.Endocrinology 123, 1128–1139.

    PubMed  CAS  Google Scholar 

  • Chee C. A., Roozendaal B., Swaab D. F., Goudsmit E., and Mirmiran M. (1988) Vasoactive intestinal polypeptide neuron changes in the senile rat suprachiasmatic nucleus.Neurobiol. Aging 9, 307–312.

    PubMed  CAS  Google Scholar 

  • Chneiweiss H., Glowinski J., and Premont J. (1984) Do secretin and vasoactive intestinal peptide have independent receptors on striatal neurons and glial cells in primary cultures?J. Neurochem. 47, 608–613.

    Google Scholar 

  • Cholewinski A. J. and Wilkin G. P. (1988) Astrocytes from forebrain, cerebellum and spinal cord differ in their responses to vasoactive intestinal peptide.J. Neurochem. 51, 1626–1633.

    PubMed  CAS  Google Scholar 

  • Chomczynski P., Down T. R., and Frohman L. A. (1988) Feedback regulation of growth hormone (GH)-releasing hormone gene expression by GH in rat hypothalamus.Mol. Endocrinol. 2, 236–241.

    PubMed  CAS  Google Scholar 

  • Cottrell G. A., Veldhuis H. D., Rostene W. H., and de Kloet E. R. (1984) Behavioral action of vasoactive intestinal peptide (VIP).Neuropeptides 4, 331–341.

    PubMed  CAS  Google Scholar 

  • Cridland R. A. and Henry J. L. (1988) Effects of intrathecal administration of neuropeptides on a spinal nociceptive reflex in the rat: VIP, galanin, CGRP, TRH, somatostatin and angiotensin II.Neuropeptides 11, 23–32.

    PubMed  CAS  Google Scholar 

  • Crowe R and Burnstock G. (1988) An increase of vasoactive intestinal polypeptide-, but not neuropeptide Y-, substance P- or catecholamine-containing nerves in the iris of the streptozotocin-induced diabetic rat.Exp. Eye Res. 47, 751–759.

    PubMed  CAS  Google Scholar 

  • Crozier T. A., Drobnik L., Stafforst D., and Kettler D. (1988) Opiate modulation of the stress-induced increase of vasoactive intestinal peptide (VIP) in plasma.Horm. Metabol. Res. 20, 352–356.

    CAS  Google Scholar 

  • Dalsgaard C.-J., Hultgardh-Nilsson A., Haegerstrand A., and Nilsson J. (1989) Neuropeptides as growth factors. Possible roles in human diseases.Regul. Pept. 25, 1–9.

    PubMed  CAS  Google Scholar 

  • Daniel E. E., Helmy-Elkholy A., Jager L. P., and Kannan M. S. (1983) Neither a purine nor VIP is the mediator of inhibitory nerves of opossum oesophageal smooth muscle.J. Physiol. (London)336, 243–260.

    CAS  Google Scholar 

  • Dartt D. A., Baker A. K., Rose P. E., Murphy S. A., Ronco L. V., and Unser M. F. (1988) Role of cyclic AMP and Ca2+ in potentiation of rat lacrimal gland protein secretion.Invest. Ophthalmol. Vis. Sci. 29, 1732–1738.

    PubMed  CAS  Google Scholar 

  • Deschodt-Lanckman M., Robberecht P., and Christophe J. P. (1977) Characterization of VIP-sensitive adenylate cyclase in guinea pig brain.FEBS Lett. 83, 76–80.

    PubMed  CAS  Google Scholar 

  • Devillier P., Matran R., and Marsac J. (1988) The nonadrenergic, noncholinergic neuropeptide system and asthma.Rev. Mal. Respir. 5, 7–20.

    PubMed  CAS  Google Scholar 

  • Dey R. D., Hoffpauir J., and Said S. I. (1988) Colocalization of vasoactive intestinal peptide- and substance P-containing nerves in cat bronchi.Neuroscience 24, 275–281.

    PubMed  CAS  Google Scholar 

  • Dixson A. F., Kendrick K. M., Blank M. A., and Bloom S. R. (1984) Effects of tactile and electrical stimuli upon release of vasoactive intestinal polypeptide in the mammalian penis.J. Endocrinol. 100, 249–252.

    PubMed  CAS  Google Scholar 

  • Dodd J., Kelly J. S., and Said S. I. (1979) Excitation of CA1 neurones of the rat hippocampus by the octacosapeptide, vasoactive intestinal peptide (VIP).Br. J. Pharmacol. 66, 126P.

    Google Scholar 

  • Drucker D. J. and Asa S. (1988) Glucagon gene expression in the vertebrate brain.J. Biol. Chem. 263, 13,475–13,478.

    CAS  Google Scholar 

  • Eckenstein F. and Baughman R.W. (1984) Two types of cholinergic innervation in cortex, one colocalized with vasoactive intestinal polypeptide.Nature 309, 153–155.

    PubMed  CAS  Google Scholar 

  • Eckenstein F. P., Baughman R. W., and Quinn J. (1988) An anatomical study of cholinergic innervation in rat cerebral cortex.Neuroscience 25, 457–474.

    PubMed  CAS  Google Scholar 

  • Ekblad E., Ekman R., Hákanson R., and Sundler F. (1988) Projections of peptide-containing neurons in rat colon.Neuroscience 27, 655–674.

    PubMed  CAS  Google Scholar 

  • el Battari A., Martin J. M., Luis J., Pouzol O., Secchi J., Marvaldi J., and Pichon J. (1988) Solubilization of the active vasoactive intestinal peptide receptor from human colonic adenocarcinoma.J. Biol. Chem. 263, 17,685–17,689.

    Google Scholar 

  • Emson P. C., Fahrenkrug J., Schaffalitzky de Muckadel O. B., Jessell T. M., and Iversen L. L. (1978) Vasoactive intestinal polypeptide (VIP): vesicular localization and potassium evoked release from rat hypothalamus.Brain Res. 143, 174–178.

    PubMed  CAS  Google Scholar 

  • Emson P. C., Gilbert R. F. T., Loren I., Fahrenkrug J., Sundler F., and Schaffalitzky de Muckadell O. B. (1979) Development of vasoactive intestinal polypeptide (VIP) containing neurones in the rat brain.Brain Res. 177, 437–444.

    PubMed  CAS  Google Scholar 

  • Epelbaum J., Tapia-Arancidia L., Besson J., Rotsztejn W., and Kordon C. (1979) Vasoactive intesinal peptide inhibits release of somatostatin from hypothalamus in vitro.Eur. J. Pharmacol. 58, 493–495.

    PubMed  CAS  Google Scholar 

  • Evans P.D. and Villegas J. (1988) The action of vasoactive intestinal peptide antagonists on peptidergic modulation of the squid Schwann cell.J. Exp. Biol. 138, 259–269.

    PubMed  CAS  Google Scholar 

  • Fahrenkrug J., Ottesen B., and Palle C. (1988) Vasoactive intestinal polypeptide and the reproductive system.Ann. NY Acad. Sci. 527, 393–404.

    PubMed  CAS  Google Scholar 

  • Falsetti L., Zanagnolo V., Gastaldi A., Memo M., and Missale C. (1988) Vasoactive intestinal polypeptide (VIP) selectively stimulates prolactin release in healthy women.Synecol. Endocrinol. 2, 11–18.

    CAS  Google Scholar 

  • Ferri G. L., Adrian T. E., Allen J. M., Soimero L., and Cancellieri A. (1988) Intramural distribution of regulatory peptides in the sigmoid-recto-anal region of the human gut.Gut 29, 762–768.

    PubMed  CAS  Google Scholar 

  • Ferron A., Siggins G. R., and Bloom F. E. (1985) Vasoactive Intestinal Peptide acts synergistically with norepinephrine to depress spontaneous discharge rate in cerebral cortical neurons.Proc. Natl. Acad. Sci. USA 82, 8810–8812.

    PubMed  CAS  Google Scholar 

  • Fink G. (1985) Has the prolactin inhibiting peptide at last been found?Nature 316, 487, 488.

    PubMed  CAS  Google Scholar 

  • Fink J. S., Verhave M., Kasper S., Tsukada T., Mandel G., and Goodman R. H. (1988) The CGTCA sequence motif is essential for biological activity of the vasoactive intestinal peptide gene cAMP-regulated enhancer.Proc. Natl. Acad. Sci. USA 85, 6662–6666.

    PubMed  CAS  Google Scholar 

  • Fink T. and Weihe E. (1988) Multiple neuropeptides in nerves supplying mammalian lymph nodes: Messenger candidates for sensory and autonomic neurotransmission.Neurosci. Lett. 90, 39–44.

    PubMed  CAS  Google Scholar 

  • Gafvelin G., Andersson M., Dimaline R., Jornvall H., and Mutt V. (1988) Isolation and characterization of a variant form of vasoactive intestinal polypeptide.Peptides 9, 469–474.

    PubMed  CAS  Google Scholar 

  • Geppetti P., De Rossi M., Mione M. C., Renzi D., and Amenta F. (1988) Age-related changes in vasoactive intestinal polypeptide levels and distribution in the rat lung.J. Neural Transm. 74, 1–10.

    PubMed  CAS  Google Scholar 

  • Giachetti A., Said S. I., Reynolds R. C., and Koniges F. C. (1977) Vasoactive intestinal polypeptide in brain: Localization and release from isolated nerve terminals.Proc. Natl. Acad. Sci. USA 74, 3414–3428.

    Google Scholar 

  • Ginzburg I. and Littauer U. Z. (1984) The expression and cellular organization of microtubule proteins: Brain specific probes in the study of differential expression during development.Molecular Biology of the Cytoskeleton (Borisy G. G., Cleveland D. W., and Murphy D. B., eds.), Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, pp. 357–366.

    Google Scholar 

  • Gjerris A., Gjerris F., Sorensen P. S., Sorensen E. B. and Christensen N. J. (1988) Do concentrations of neurotransmitters measured in lumbar cerebrospinal fluid reflect the concentrations at brain level.Acta Neurochir. 91, 55–59.

    CAS  Google Scholar 

  • Goetzl E. J., Sreedharan S. P., and Turck C. W. (1988) Structurally distinctive vasoactive intestinal peptides from rat basophilic leukemia cells.J. Biol. Chem. 263, 9083–9086.

    PubMed  CAS  Google Scholar 

  • Gordeladze J. O., Sletholt K., Thorn N. A., and Gautvik K. M. (1988) Hormone-sensitive adenylate cyclase of prolactin-producing rat pituitary adenoma (GH4Cl) cells: Molecular organization.Eur. J. Biochem. 177, 665–672.

    PubMed  CAS  Google Scholar 

  • Gorden P., Comi R. J., and Maton P. N. (1989) NIH conference. Somatostatin and somatostatin analogue (SMS 201–995) in treatment of hormone-secreting tumors of the pituitary and gastrointestinal tract and non-neoplastic diseases of the gut.Ann. Intern. Med. 110, 35–50.

    PubMed  CAS  Google Scholar 

  • Gotoh E., Yamagami T., Yamamoto H., and Okamoto, H. (1988) Chromosomal assignment of human VIP/PHM-27 gene to 6q26–q27 region by spot blot hybridization and in situ hybridization.Biochem. Int. 17, 555–562.

    PubMed  CAS  Google Scholar 

  • Gourdji D., Bataille D., Vauclin N., Grouselle D., Rosselin G., and Tixier-Vidal A. (1979) Vasoactive intestinal peptide (VIP) stimulates prolactin (PRL) release and cAMP production in a rat pituitary cell line (GH3/B6). Additive effects of VIP and TRH on PRL release.FEBS Lett. 104, 165–168.

    PubMed  CAS  Google Scholar 

  • Gozes I., Milner R. J., Liu F.-T., Johnson E., Battenberg E. L. F., Katz D., and Bloom F. E. (1983a) Monoclonal antibodies against vasoactive intestinal polypeptide: Studies of structure and related antigens.J. Neurochem. 41, 549–556.

    PubMed  CAS  Google Scholar 

  • Gozes I., O’Connor D. T., and Bloom F. E. (1983b) A possible high molecular weight precursor to vasoactive intestinal polypeptide sequestered into catecholamine storage granule preparation.Regul. Pept. 6, 111–119.

    PubMed  CAS  Google Scholar 

  • Gozes I., Bodner M., Shani Y., and Fridkin M. (1984a) Detection of mRNAs containing regulatory peptide sequences using synthetic oligodeoxynucleotide probes.J. Cell Biochem. 26, 147–156.

    PubMed  CAS  Google Scholar 

  • Gozes I., Bodner M., Shwartz H., Shani Y., and Fridkin M. (1984b) Studies toward the biosynhesis of vasoactive intestinal peptide (VIP).Peptides 5, 161–166.

    PubMed  CAS  Google Scholar 

  • Gozes I., Bodner M., Shani Y., and Fridkin M. (1986) Structure and expression of the vasoactive intestinal peptide (VIP) gene in a human tumor.Peptides 7, 1–6.

    PubMed  CAS  Google Scholar 

  • Gozes I. and Shani Y. (1986) Hypothalamic VIP-mRNA is increased in lactating rats.Endocrinol. 119, 2497–2501.

    CAS  Google Scholar 

  • Gozes I. and Tsafriri A. (1986) Detection of VIP-encoding mRNA in the rat ovaries.Endocrinol. 119, 2606–2610.

    CAS  Google Scholar 

  • Gozes I. (1987) VIP gene expression.Brain Peptides (update volume 1), chapter 10 (Martin J. B., Brownstein M. J., and Krieger D., eds.), Wiley, NY, pp. 141–162.

    Google Scholar 

  • Gozes I., Avidor R., Katznelson D., Yahav Y., Croce C., and Hubner K. (1987a) The gene encoding vasoactive intestinal peptide is located on human chromosome 6p21-6qter.Hum. Genet. 75, 41–44.

    PubMed  CAS  Google Scholar 

  • Gozes I., Nakai H., Byers M., Avidor R., Weinstein Y., Shani Y., and Shows T. B. (1987b) Sequential expression in the nervous system of the VIP and c-myb genes located on the human chromosomal region 6q24.Somatic Cell and Mol. Gen. 13, 305–313.

    CAS  Google Scholar 

  • Gozes I., Giladi E., and Shani Y. (1987c) VIP-gene expression: Putative mechanism of information storage at the RNA level.J. Neurochem. 48, 1136–1141.

    PubMed  CAS  Google Scholar 

  • Gozes I., Shani Y., and Rostene W. H. (1987d) Developmental expression of the VIP-gene in brain and intestine.Mol. Brain Res. 2, 137–148.

    CAS  Google Scholar 

  • Gozes I., Shachter P., Shani Y., and Giladi E. (1988) Vasoactive intestinal peptide gene expression from embryos to aging rats.Neuroendocrinology 47, 27–31.

    PubMed  CAS  Google Scholar 

  • Gozes I., Avidor R., Biegon A., and Baldino F., Jr. (1989a) Lactation elevates vasoactive intestinal peptide messenger ribonucleic acid in rat suprachiasmatic nucleus.Endocrinol. 124, 181–186.

    CAS  Google Scholar 

  • Gozes I., Fridkin M., and Brenneman D. E. (1989b) A novel antagonist to vasoactive intestinal peptide.Soc. Neurosci. Abstr. 15, 216 (abstr. 921).

    Google Scholar 

  • Gozes I., Meltzer E., Rubinrout S., Brenneman D. E., and Fridkin M. (1989c) Vasoactive intestinal peptide potentiates sexual behavior: Inhibition by novel antagonist.Endocrinol., in press.

  • Gozes I., Shani Y., Liu B., and Burbach, J. P. H. (1989d) Diurnal variations in vasoactive intestinal peptide messenger RNA in the suprachiasmatic nucleus of the rat.Neurosci. Res. Commuun., in press.

  • Gozes I., Werner H., Fawzi M. A. A., Shani Y., Fridkin M., and Koch Y. (1989e) Estrogen regulation of vasoactive intestinal peptide mRNA in the rat hypothalamus.J. Mol. Neurosci. 1, 55–61.

    PubMed  CAS  Google Scholar 

  • Gubits R. M., Hazelton J. L., and Simantov R. (1988) Variation in c-fos gene expression during rat brain development.Mol. Brain Res. 3, 197–202.

    Google Scholar 

  • Guillemin R., Brazeau P., Bohlen P., Esch F., Fing N., and Wehrenberg W. B. (1982) Growth hormone-releasing factor from a human pancreatic tumor that caused acromegaly.Science 218, 505–507.

    Google Scholar 

  • Hajos F., Zilles K., Gallatz K., Schleicher A., and Kaplan I. (1988) Ramification patterns of vasoactive intestinal polypeptide (VIP)-cells in the rat primary visual cortex. An immunohistochemical study.Anat. Embryol. 178, 197–206.

    PubMed  CAS  Google Scholar 

  • Haskins J. T., Samson W. K., and Moss R. L. (1982) Evidence for vasoactive intestinal polypeptide (VIP) altering the firing rate of preoptic, septal and midbrain central gray neurons.Reg. Pept. 3, 113–123.

    CAS  Google Scholar 

  • Hayakawa Y., Obata K.-I., Itoh N., Yanaihara N., and Okamoto H. (1984) Cyclic AMP regulation of pro-vasoactive intestinal polypeptide/PHM-27 synthesis in human neuroblastoma cells.J. Biol. Chem. 259, 9207–9211.

    PubMed  CAS  Google Scholar 

  • Haynes L. W. (1985) Modulation of cholinergic transmission by VIP, a peptide co-transmitter.Trends Pharmacol. 6, 427, 428.

    CAS  Google Scholar 

  • Hedlund B., Dufy B., and Barker L. (1988) Vasoactive intestinal polypeptide alters GH3/B6 pituitary cell excitability.Pflugers Arch. 411, 173–179.

    PubMed  CAS  Google Scholar 

  • Heinrich G., Gros P., and Habener J. F. (1984) Glucagon gene sequence: Four of six exons encode separate functional domains of rat pre-proglucagon.J. Biol. Chem. 259, 14,082–14,087.

    CAS  Google Scholar 

  • Heinz-Erian P., Dey R. D., Flux M., and Said S. I. (1985) Deficient vasoactive intestinal peptide innervation in the sweat glands of cystic fibrosis patients.Science 229, 1407, 1408.

    PubMed  CAS  Google Scholar 

  • Hejblum G., Gali P., Boissard C., Astesamo A., Hui B., and Rosselin G. (1988) Combined ultrastructural and biochemical study of cellular processing of vasoactive intestinal peptide and its receptors in human colonic carcinoma cells in culture.Cancer Res. 48, 6201–6210.

    PubMed  CAS  Google Scholar 

  • Helke C. J. and Hill K. M. (1988) Immunohistochemical study of neuropeptides in vagal and glossopharyngeal afferent neurons in the rat.Neuroscience 26, 539–551.

    PubMed  CAS  Google Scholar 

  • Hill J. M., Farrar W. L., and Pert C. B. (1986) Localization of the T4 antigen/AIDS virus receptor in monkey and rat brain: Prominence in cortical regions.Psychopharmacol. Bull. 22, 689–694.

    PubMed  CAS  Google Scholar 

  • Hioki Y., Hoshino M., Yanaihara C., Ogino K., Sato H., and Yanaihara N. (1983) Characterization of VIP-like immunoreactivity in a human neuroblastoma cell line,Peptide Chemistry 1982, Sakakibara S., ed., Protein Research Foundation, Osaka, Japan, pp. 263–266.

    Google Scholar 

  • Hisano S., Chikamori-Aoyama M., Katoh S., Kagotani Y., Daikoku S., and Chihara K. (1988) Suprachiasmatic nucleus neurons immunoreactive for vasoactive intestinal neuropeptide have synaptic contacts with axons immunoreactive for neuropeptide Y: An immunoelectron microscopic study in the rat.Neurosci. Lett. 26, 145–150.

    Google Scholar 

  • Hokfelt T., Johansson O., Ljungdahl A., Lunberg J. M., and Schultzberg M. (1980) Peptidergic neurons,Nature 284, 515–521.

    PubMed  CAS  Google Scholar 

  • Hultgardh-Nilsson A., Nilsson J., Jonzon B., and Dalsgaard C. J. (1988) Growth-inhibitory properties of vasoactive intestinal peptide.Reg. Pept. 22, 267–274.

    CAS  Google Scholar 

  • Hunter L. W., Rorie D. K., Yaksh T. L., and Tyce G. M. (1988) Concurrent separation of catecholamines, vasoactive intestinal peptide, and neuropeptide Y in superfusate and tissue extract.Anal. Biochem. 173, 340–352.

    PubMed  CAS  Google Scholar 

  • Hyman S. E., Comb M., Lin Y.-S., Pearlberg J., Green M. R., and Goodman H. M. (1988) A common transacting factor is involved in transcriptional regulation of neurotransmitter genes by cyclic AMP.Mol. Cell. Biol. 8, 4225–4233.

    PubMed  CAS  Google Scholar 

  • Ichikawa H., Nishikawa S., Wakisaka S., Matsuo S., and Takano Y. (1988) Coexistence of vasoactive intestinal polypeptide- and substance P-like immunoreactivities in the tongue of the guinea pig.Neurosci. Lett. 89, 283–285.

    PubMed  CAS  Google Scholar 

  • Inoue Y. and Kanno T. (1982) Secretory effects of vasoactive intestinal polypeptide (VIP), adrenaline and carbachol in isolated lobules of the rat parotid gland.Bio. Res. 3, 384–389.

    CAS  Google Scholar 

  • Ito S., Kimura A., and Ohga A. (1988) Development of noncholinergic, non-adrenergic excitatory and inhibitory responses to intramural nerve stimulation in rat stomach.Br. J. Pharmacol. 93, 684–692.

    PubMed  CAS  Google Scholar 

  • Itoh N., Obata K., Yanaihara N., and Okamoto H. (1983) Human preprovasoactive intestinal polypeptide contains a novel PHI-27-Like peptide, PHM-27.Nature 304, 547–549.

    PubMed  CAS  Google Scholar 

  • Johansson O. and Lundberg J. M. (1981) Ultrastructural localization of VIP-Like immunoreactivity in large dense-core resides of ‘cholinergic-type’ nerve terminals in cat exocrine glands.Neuroscience 6, 847–862.

    PubMed  CAS  Google Scholar 

  • Kaji A., Shigematsu H., Fujita K., Maeda T., and Watanabe S. (1988) Parasympathetic innervation of cutaneous blood vessels by vasoactive intestinal polypeptide-immunoreactive and acetylcholinesterase-positive nerves: Histochemical and experimental study on rat lower lip.Neurosci. 25, 353–362.

    CAS  Google Scholar 

  • Kaji H., Kazuo C., Abe H., Kita T., Kashio Y., Okimura Y., and Fujita T. (1985) Effect of passive immunization with antisera to vasoactive intestinal polypeptide and peptide histidine isoleucine amide on S-Hydroxy-L-Tryptophan-induced prolactin release in rats.Endocrinol. 117, 1914–1919.

    CAS  Google Scholar 

  • Kamata K., Sakamoto A., and Kasuya Y. (1988) Changes in sensitivity of the rat stomach fundus to various drugs in streptozotocin-induced diabetic rats.Jpn. J. Pharmacol. 47, 99–102.

    PubMed  CAS  Google Scholar 

  • Kanamatsu T. and Hirano S. (1988) Differences in ME-LI and VIP-LI in discrete brain regions of seizure-naive and seizure-experienced E1 miceNeurochem. Res. 13, 983–988.

    PubMed  CAS  Google Scholar 

  • Kawatani M., Rutigliano M., and de Groat W. C. (1985) Depolarization and muscarinic excitation induced in a sympathetic ganglion by vasoactive intestinal polypeptide.Science 229, 879–881.

    PubMed  CAS  Google Scholar 

  • Kerins C. and Said S. I. (1973) Hyperglycemic and glycogenolotic effects of vasoactive intestinal polypeptide.Proc. Soc. Exp. Biol. Med. 142, 1014–1017.

    PubMed  CAS  Google Scholar 

  • King J. T., Jr. and LaMotte C. C. (1988) VIP-, SS-, and GABA-like immunoreactivity in the mid-hippocampal region of E1 (epileptic) and C578L/6 mice.Brain Res. 475, 192–197.

    PubMed  Google Scholar 

  • Klein C. M. and Burden H. W. (1988) Substance P- and vasoactive intestinal polypeptide (VIP)-immunoreactive nerve fibers in relation to ovarian postganglionic perikarya in para- and prevertebral ganglia: Evidence from combined retrograde tracing and immunocytochemistry.Cell Tissue Res. 252, 403–410.

    PubMed  CAS  Google Scholar 

  • Knapp T. R., Fehrer S. C., Silsby J. L., Porter T. E., and Behnke E. J. (1988) Gonadal steroid modulation of basal and vasoactive intestinal polypeptide-stimulated prolactin release by turkey anterior pituitary cells.Gen. Comp. Endocrinol. 72, 226–236.

    PubMed  CAS  Google Scholar 

  • Koh S.-W. M., Kyritsis A., and Chader G. J. (1984) Interaction of neuropeptides and cultured glial (Muller) cells of the chick retina: Elevation of intracellular cyclic AMP by vasoactive intestinal peptide and glucagon.J. Neurochem. 43, 199–203.

    PubMed  CAS  Google Scholar 

  • Krieger D. T., Brownstein M. J., and Martin J. B. (1983)Brain Peptides, Wiley, New York.

    Google Scholar 

  • Kummer W. and Heym C. (1988) Neuropeptide distribution in the cervico-thoracic paravertebral ganglia of the cat with particular reference to calcitonin gene-related peptide immunoreactivity.Cell Tissue Res. 252, 463–471.

    PubMed  CAS  Google Scholar 

  • Laburthe M. and Couvinneau A. (1988) Molecular analysis of vasoactive intestinal peptide receptors. Vasoactive intestinal peptide and related peptides, Said S. I. and Mutt V., eds.,Ann. NY Acad Sci. 527, 296–313.

    PubMed  CAS  Google Scholar 

  • Laburthe M., Breant B., and Rouyer-Fessard C. (1984) Molecular identification of receptors for vasoactive intestinal peptide in rat intestinal epithelium by covalent cross-linking. Evidence for two classes of binding sites with different structural and functional properties.Eur. J. Biochem. 139, 181–187.

    PubMed  CAS  Google Scholar 

  • Laemle L. K. (1988) Vasoactive intestinal polypeptide (VIP)-like immunoreactivity in the suprachiasmatic nucleus of the perinatal rat.Brain Res. 469, 308–312.

    PubMed  CAS  Google Scholar 

  • Lam K. S., Lechan R. M., Minamitani N., Segerson T. P., and Reichlin S. (1989) Vasoactive intestinal peptide in the anterior pituitary is increased in hypothyroidism.Endocrinol. 124, 1077–1084.

    CAS  Google Scholar 

  • LaMotte C. C. (1988) Lamina X of primate spinal cord: distribution of five neuropeptides and serotonin.Neurosci. 25, 639–658.

    CAS  Google Scholar 

  • Lasater E. M., Watling K. J., and Dowling J. E. (1983) Vasoactive intestinal peptide alters membrane potential and cyclic nucleotide levels in retinal horizontal cells.Science 221, 1070–1072.

    PubMed  CAS  Google Scholar 

  • Lee T. J., Saito A., and Berezin I. (1984) Vasoactive intestinal polypeptide-like substance: the potential transmitter for cerebral vasodilation.Science 224, 898–901.

    PubMed  CAS  Google Scholar 

  • Levy Holtzman R., Malach R., and Gozes I. (1989) Disruption of the optic pathway during development affects vasoactive intestinal peptide mRNA expression.New Biologist, in press.

  • Lewin B. (1983)Genes, Wiley, New York.

    Google Scholar 

  • Lin Y.-S. and Green M. R. (1988) Interaction of a common cellular transcription factor, ATF, with regulatory elements in both Ela- and cyclic AMP-inducible promoters.Proc. Natl. Acad. Sci. USA 85, 3396–3400.

    PubMed  CAS  Google Scholar 

  • Linder S. T., Barkhem A., Norberg H., Person M., Schalling M., Hokfelt T., and Magnusson G. (1987) Structure and expression of the gene encoding the vasoactive intestinal peptide precursor.Proc. Natl. Acad. Sci. USA 84, 605–609.

    PubMed  CAS  Google Scholar 

  • Liu Y.-X., Kasson B. G., Dahl K. D., and Hsueh A. J. W. (1987) Vasoactive intestinal peptide stimulate plasminogen activator activity by cultured rat granulosa cells and cumulus-oocyte complexes.Peptide 8, 29–33.

    CAS  Google Scholar 

  • Lopez F. J., Dominguez J. R., Sanchez-Franco F., and Negro Vilar A. (1989) Role of dopamine and vasoactive intestinal peptide in the control of pulsatile prolactin secretion.Endocrinol. 124, 527–535.

    CAS  Google Scholar 

  • Luine V. N., Rostene W., Rhodes J., and McEwen B. S. (1984) Activation of choline acetyl transferase by vasoactive intestinal peptide.J. Neurochem. 42, 1131–1134.

    PubMed  CAS  Google Scholar 

  • Luis J., Martin J. M., el Battari A., Marvaldi J., and Pichon J. (1988) The vasoactive intestinal peptide (VIP) receptor: recent data and hypothesis.Biochimie 70, 1311–1322.

    PubMed  CAS  Google Scholar 

  • Lundberg J. M., Hedlund B., and Bartfai T. (1982) Vasoactive intestinal polypeptide enhances muscarinic ligand binding in cat submandibular salivary gland.Nature 295, 147–149.

    PubMed  CAS  Google Scholar 

  • Magistretti P. J., Morrison J. H., Shoemaker W. J., Sapin V., and Bloom F. E. (1981) Vasoactive intestinal polypeptide induces glycogenolysis in mouse cortical slices: A possible regulatory mechanism for the local control of energy metabolism.Proc. Natl. Acad. Sci. USA 78, 6535–6539.

    PubMed  CAS  Google Scholar 

  • Magistretti P. J. and Schorderet M. (1984) VIP and noradrenaline act synergistically to increase cyclic AMP in cerebral cortex.Nature 308, 280–282.

    PubMed  CAS  Google Scholar 

  • Magistretti P. J. (1988) Regulation of glycogenolysis by neurotransmitters in the central nervous system.Diabetes Metab. 14, 237–246.

    CAS  Google Scholar 

  • Mains R. E., Eipper B. A., Glembotski C. C., and Dores R. M. (1983) Strategies for the biosynthesis of bioactive peptides.Trends Neurosci. 6, 229–235.

    CAS  Google Scholar 

  • Makhlouf G. M., Zfass A. M., Said S. I., and Schebalin M. (1978) Effects of synthetic vasoactive intestinal peptide (VIP), secretin and their partial sequences or gastric secretion.Proc. Soc. Exp. Biol. Med. 157, 565–568.

    PubMed  CAS  Google Scholar 

  • Malhotra R. K., Wakade T. D., and Wakade A. R. (1988) Vasoactive intestinal polypeptide and muscarine mobilize intracellular Ca2+ through breakdown of phosphoinositides to induce catecholamine secretion.J. Biol. Chem. 263, 2123–2126.

    PubMed  CAS  Google Scholar 

  • Marchis-Mouren G., Martin J. M., Luis J., el Battari A., Muller J. M., Marvaldi J., and Pichon J. (1988) HT 29, a model cell line: Stimulation by the vasoactive intestinal peptide (VIP); VIP receptor structure and metabolism.Biochimie 70, 663–667.

    PubMed  CAS  Google Scholar 

  • Marie J.-C., Hoa D., Jackson R., Hejblum G., and Rosselin G. (1985) The biological relevance of HPLC-purified vasoactive intestinal polypeptide monoiodinated at tyrosine 10 or tyrosine 22.Reg. Pept. 12, 113–123.

    CAS  Google Scholar 

  • Masuko S. and Chiba T. (1988) Projection pathways, co-existence of peptides and synaptic organization of nerve fibers in the inferior mesenteric ganglion of the guinea-pig.Cell Tissue Res. 253, 507–516.

    PubMed  CAS  Google Scholar 

  • Mayo K. E., Cerelli G. M., Lebo R. V., Bruce B. D., Rosenfeld M. G., and Evans R. M. (1985) Gene encoding human growth hormone-releasing factor precursor: Structure, sequence, and chromosomal assignment.Proc. Natl. Acad. Sci. USA 82, 63–67.

    PubMed  CAS  Google Scholar 

  • McCann S. M., Lumpkin M. D., Mizunuma H., Khorram O., Ottlecz A., and Samson W. K. (1984) Peptidergic and dopaminergic control of prolactin release.Trends Neurosci. 7, 127–131.

    CAS  Google Scholar 

  • McGregor G. P., Woodhams P. L., O’Shaughnessy D. J., Ghatei M. A., Polak J. M., and Bloom S. R. (1982) Developmental changes in bombesin, substance P, somatostatin and vasoactive intestinal polypeptide in the rat brain.Neurosci. Lett. 28, 21.

    PubMed  CAS  Google Scholar 

  • Mezey E. and Kiss J. Z. (1985) Vasoactive intestinal peptide-containing neurons in the paraventricular nucleus may participate in regulating prolactin secretion.Proc. Natl. Acad. Sci. USA 82, 245–247.

    PubMed  CAS  Google Scholar 

  • Mihara S., Katayama Y., and Nishi S. (1985) Slow postsynaptic potentials in neurons of submucous plexus of guinea-pig caecum and their mimicry by noradrenaline and various peptides.Neurosci. 16, 1057–1068.

    CAS  Google Scholar 

  • Mikkelsen J. D. and Moller M. (1988) Vasoactive intestinal peptide in the hypothalamo-hypophysial system of the Mongolian gerbil.J. Comp. Neurol. 1, 87–98.

    Google Scholar 

  • Misbahuddin M., Oka M., Nakanishi A., and Morita K. (1988) Stimulatory effect of vasoactive intestinal polypeptide on catecholamine secretion from isolated guinea pig adrenal chromaffin cells.Neurosci. Lett. 92, 202–206.

    PubMed  CAS  Google Scholar 

  • Miskimins W. K., Roberts M. P., McClelland A., and Ruddle F. H. (1985) Use of a protein-blotting procedure to identify nuclear proteins that recognize the promoter region of the transferrin receptor gene.Proc. Natl. Acad. Sci. USA 82, 6741–6744.

    PubMed  CAS  Google Scholar 

  • Mitsuhashi M. and Payan D. G. (1987) The mitogenic effects of vasoactive neuropeptides on cultured smooth muscle cell lines.Life Sci. 40, 853–861.

    PubMed  CAS  Google Scholar 

  • Mo N. and Dun N. J. (1984) Vasoactive intestinal polypeptide facilitates muscarinic transmission in mammalian sympathetic ganglia.Neurosci. Lett. 52, 19–23.

    PubMed  CAS  Google Scholar 

  • Montminy M. R. and Bilezikjian L. M. (1987) Binding of a nuclear protein to the cyclic AMP responsive element of the somatostatin gene.Nature 328, 175–178.

    PubMed  CAS  Google Scholar 

  • Moore D. D., Marks A. R., Buckley D. I., Kapler G., Payvar F., and Goodman H. M. (1985) The first intron of the human growth hormone gene contains a binding site for glucocorticoid receptor.Proc. Natl. Acad Sci USA 82, 699–702.

    PubMed  CAS  Google Scholar 

  • Moore T. C., Spruck C. H., and Said S. I. (1988) Depression of lymphocyte traffic in sheep by vasoactive intestinal peptide (VIP).Immunol. 64, 475–478.

    CAS  Google Scholar 

  • Moore R. Y. (1983) Organization and function of a central nervous system circadian oscillator: The suprachiasmatic hypothalamic nucleus.Fed. Proc. 42, 2783–2789.

    PubMed  CAS  Google Scholar 

  • Morel G., Besson J., Rosselin G., and Dubois P. M. (1982) Ultrastructural evidence for endogenous vasoactive intestinal peptide-like immunoreactivity in the pituitary gland.Neuroendocrinol. 34, 85–89.

    CAS  Google Scholar 

  • Morrison J. H., Magistretti P. J., Benoit R., and Bloom F. E. (1984) The distribution and morphological characteristics of the intracortical VIP-positive cells: An immunohistochemical analysis.Brain Res. 292, 269–282.

    PubMed  CAS  Google Scholar 

  • Munemura M., Agui T., and Sibley D. R. (1989) Chronic estrogen treatment promotes a functional uncoupling of the D2 dopamine receptor in rat anterior pituitary gland.Endocrinol. 124, 346–355.

    CAS  Google Scholar 

  • Murai I., Reichlin S., and Ben-Jonathan N. (1989) The peak phase of the proestrous prolactin surge is blocked by either posterior pituitary lobectomy or antisera to vasoactive intestinal peptide.Endocrinol. 124, 1050–1055.

    CAS  Google Scholar 

  • Nguyen T. D. (1989) Peptide T from human immunodeficiency virus envelope does not interact with hepatic, intestinal and colonic vasoactive intestinal peptide (VIP) receptors.Peptides 9, 425–428.

    Google Scholar 

  • Nichols R., Lee T. D., and Andrews P. C. (1988) Pancreatic proglucagon processing: Isolation and structures of glucagon and glucagon-like peptide from gene I.Endocrinol. 123, 2639–2645.

    CAS  Google Scholar 

  • Nishizawa M., Hayakawa Y., Yanihara N., and Okamoto H. (1985) Nucleotide sequence divergence and functional constraint in VIP precursor mRNA evolution between human and rat.FEBS Lett. 183, 55–59.

    PubMed  CAS  Google Scholar 

  • Nobou F., Besson J., Rostene W., and Rosselin G. (1985) Ontogeny of vasoactive intestinal peptide and somatostatin in different structures of the rat brain: Effects of hypo- and hypercorticism.Dev. Brain Res. 20, 296–301.

    CAS  Google Scholar 

  • Noguchi T., Sugisaki T., Kanamatsu T., Satoh I., and Nishikawa, N. (1988) Reduced vasoactive intestinal polypeptide immunoreactivity in the pituitaries of hormone-deficient mutant mice.J. Endocrinol. 118, 179–185.

    PubMed  CAS  Google Scholar 

  • Nurko S., Dunn B. M., and Rattan S. (1989) Peptide histidine isoleucine and vasoactive intestinal polypeptide cause relaxation of opossum internal anal sphincter via two distinct receptors.Gastroenterol. 96, 403–414.

    CAS  Google Scholar 

  • Obata K., Itoh N., Okamoto H., Yanaihara C., Yanaihara N., and Suzuki T. (1981) Identification and processing of biosynthetic precursors to vasoactive intestinal polypeptide in human neuroblastoma cells.FEBS Lett. 136, 123–126.

    PubMed  CAS  Google Scholar 

  • Ohsawa K., Hayakawa Y., Nishiawa M., Yamagami T., Yamamoto H., Yanaihara N., and Okamoto H. (1985) Synergistic stimulation of VIP/PHM-27 gene expression by cyclic AMP and phorbol esters in human neuroblastoma cells.Biochem. Biophys. Res. Commun. 132, 885–891.

    PubMed  CAS  Google Scholar 

  • Ohtsuka S., Miyake A., Nishizaki T., Tasaka K., and Tanizawa O. (1988) Vasoactive intestinal peptide stimulates gonadotrophic-releasing hormone release from rat hypothalamus in vitro.Acta Endocrinol. 117, 399–402.

    PubMed  CAS  Google Scholar 

  • Ollerenshaw S., Jarvis D., Woolcock A., Sullivan C., and Scheibner T. (1989) Absence of immunoreactive vasoactive intestinal peptide in tissue from the lungs of patients with asthma.N. Engl. J. Med. 320, 1244–1248.

    PubMed  CAS  Google Scholar 

  • Ottaway C. A. and Greenberg G. R. (1984) Interaction of vasoactive intestinal peptide with mouse lymphocytes: Specific binding and the modulation of mitogen responses.J. Immunol. 132, 417–423.

    PubMed  CAS  Google Scholar 

  • Ottesen B., Wagner G., Virag R., and Fahrenkrug J. (1984) Penile erection: Possible role for vasoactive intestinal polypeptide as a neurotransmitter.Br. Med. J. 288, 9–11.

    CAS  Google Scholar 

  • Pandol S. J., Dharmsathaphorn K., Schoeffield M. S., Vale W., and Rivier J. (1986) Vasoactive intestinal peptide receptor antagonist (4Cl-D-Phe6, Leu17) VIP.Am. J. Physiol. 250, G553-G557.

    PubMed  CAS  Google Scholar 

  • Patthi S., Simerson S., and Velicelebi G. (1988) Solubilization of rat lung vasoactive intestinal peptide receptors in the active state. Characterization of the binding properties and comparison with membrane-bound receptors.J. Biol. Chem. 263, 19,363–19,369.

    CAS  Google Scholar 

  • Paul S. (1989) Decreased selectivity of vasoactive intestinal peptide receptors by GTP.Biochem. Pharmacol. 38, 699–702.

    PubMed  CAS  Google Scholar 

  • Paul S. and Said S. I. (1985) Solubilization and physical separation of active high- and low-affinity receptors for vasoactive intestinal peptide (VIP).Reg. Pept. 3, S52.

    Google Scholar 

  • Paul S. and Said S. I. (1988) Human autoantibody to vasoactive intestinal peptide: Increased incidence in muscular exercise.Life Science 43, 1079–1084.

    CAS  Google Scholar 

  • Pelletier G., Leclerc R., Puviani R., and Polak J. (1981) Electron immunocytochemistry in vasoactive intestinal polypeptide (VIP) in the rat brain.Brain Research 210, 356–360.

    PubMed  CAS  Google Scholar 

  • Perry V. H. and Gordon S. J. (1987) Modulation of CD4 antigen on macrophages and microglia in rat brain.J. Exp. Med. 166, 1138–1143.

    PubMed  CAS  Google Scholar 

  • Pert C. B., Hill J. M., Ruff M. R., Berman R. M., Robey W. G., Arthur L. O., Ruscetti F. W., and Farrar W. L. (1986) Octapeptides deduced from the neuropeptide receptor-like pattern of antigen T4 in brain potently inhibit human immunodeficiency virus receptor binding and T-cell infectivity.Proc. Natl. Acad. Sci. USA 83, 9254–9258.

    PubMed  CAS  Google Scholar 

  • Pert C. B., Smith C. C., Ruff M. R., and Hill J. M. (1988) AIDS and its dementia as a neuropeptide disorder: role of VIP receptor blockade by human immunodeficiency virus envelope.Ann. Neurol. 23, S71-S73.

    PubMed  CAS  Google Scholar 

  • Philippe J., Drucker D. J., Knepel W., Jepeal L., Misulovin Z., and Habener J. F. (1988) Alpha-cell-specific expression of the glucagon promoter element by the interaction of DNA-binding proteins.Mol. Cell. Biol. 8, 4877–4888.

    PubMed  CAS  Google Scholar 

  • Phillis J. W., Kirkpartick J. R., and Said, S. I. (1978) Vasoactive intestinal polypeptide excitation of central neurons.Can. J. Physiol. Pharmacol. 56, 337–340.

    PubMed  CAS  Google Scholar 

  • Piper P. J., Said S. I., and Vane J. R. (1970) Effects on smooth muscle preparation of identified vasoactive peptides from intestine and lung.Nature 225, 1144–1146.

    PubMed  CAS  Google Scholar 

  • Pless D. D. and Lennarz, W. J. (1977) Enzymatic conversion of proteins to glycoproteins.Proc. Natl. Acad. Sci. USA 74, 134–138.

    PubMed  CAS  Google Scholar 

  • Poston G. J., Yao C. Z., Upp J. R., Alexander R. W., Townsend C. M., and Thompson J. C. (1988) Vasoactive intestinal peptide inhibits the growth of hamster pancreatic cancer but not human pancreatic cancer in vivo.Pancreas 3, 439–443.

    PubMed  CAS  Google Scholar 

  • Pruss R. M., Moskal J. R., Eiden L. E., and Beinfeld M. C. (1985) Specific regulation of vasoactive intestinal polypeptide biosynthesis by phorbol ester in bovine chromaffin cells.Endocrinol. 117, 1020–1026.

    CAS  Google Scholar 

  • Quik M., Iversen L. L., and Bloom S. R. (1978) Effect of vasoactive intestinal peptide (VIP) and other peptides on cAMP accumulation in rat brain.Biochem. Pharmacol. 27, 2209–2213.

    PubMed  CAS  Google Scholar 

  • Rauscher F. J., III, Cohen D. R., Curran T., Bos T. J., Vogt P. K., Bohmann D., Tjian R., Franza B. R., Jr. (1988) Fos-associated protein p39 is the product of the june proto-oncogene.Science 240, 1010–1016.

    PubMed  CAS  Google Scholar 

  • Reichlin S. (1988) Neuroendocrine significance of vasoactive intestinal polypeptide.Ann. NY Acad. Sci. 527, 431–449.

    PubMed  CAS  Google Scholar 

  • Reid A. M., Shulkes A., and Titchen D. A. (1988) Effects of the vagus nerves on gastric motility and release of vasoactive intestinal polypeptide in the anaesthetized lamb.J. Physiol. 396, 11–24.

    PubMed  CAS  Google Scholar 

  • Riabowol K. T., Fink J. S., Gilman M. Z., Walsh D. A., Goodman R. H., and Feramisco J. R. (1988) The catalytic subunit of cAMP-dependent protein kinase induces expression of genes containing cAMP responsive elements.Nature 336, 83–86.

    PubMed  CAS  Google Scholar 

  • Robberecht P., De Neef P., Lammens M., Deschodt-Lanckman M., and Christophe J. P. (1978) Specific binding of vasoactive intestinal peptide to brain membranes of the guinea pig.Eur. J. Biochem. 90, 147–154.

    PubMed  CAS  Google Scholar 

  • Robberecht P., Vandermeers A., Vandermeers-Piret M. C., Svoboda M., DeNeef P., DeGraef J., Woussen-Colle M. C., Yanaihara N., Yanaihara C., and Christophe J. (1985) Immunoreactive helodermin a new candidate neuropeptide in Mammalian.Reg. Pep. 3, S17.

    Google Scholar 

  • Robbins R. and Landon R. M. (1985) The effects of neurotensin, vasoactive intestinal polypeptide and other neuropeptides on the secretion of somatostatin from cerebral cortical cells.Brain Res. 332, 161–164.

    PubMed  CAS  Google Scholar 

  • Rosselin G., Anteunis A., Astesano C., Boissard C., Boissard Gall P., Hejblum G., and Marie, J. C. (1988) Regulation of the vasoactive intestinal peptide receptor.Ann. NY Acad. Sci. 527, 220–237.

    PubMed  CAS  Google Scholar 

  • Rostene W. H. (1984) Neurobiological and neuroendocrine functions of the vasoactive intestinal peptide (VIP).Prog. Neurobiol. 22, 103–129.

    PubMed  CAS  Google Scholar 

  • Rotsztejn W. H., Benoist L., Besson J., Beraud G., Bluet-Pajot M. T., Kordon G., Rosselin G., and Duval J. (1980) Effect of vasoactive intestinal peptide (VIP) on the release of adenohypophyseal hormones from purified cells obtained by unit gravity sedimentation.Neuroendocrinol. 31, 282–286.

    CAS  Google Scholar 

  • Ruberg M., Rotszteijn W. H., Arancibia S., Besson J., and Enjalbert A. (1978) Stimulation of prolactin release by vasoactive intestinal peptide.Eur. J. Pharmacol. 51, 319, 320.

    PubMed  CAS  Google Scholar 

  • Ruff M. R., Martin B. M., Ginns E. I., Farrar W. L., and Pert C. B. (1987) CD4 receptor binding peptides that block HIV infectivity cause human monocyte chemotaxis. Relationship to vasoactive intestinal peptide.FEBS Lett. 211, 17–22.

    PubMed  CAS  Google Scholar 

  • Sacerdote P., Ruff M. R., and Pert C. B. (1987) Vasoactive intestinal peptide (1–12): A ligand for the CD4 (T4)/human immunodeficiency virus receptor.J. Neurosci. Res. 18, 102–107.

    PubMed  CAS  Google Scholar 

  • Said S. I. and Mutt V. (1970) Polypeptide with broad biological activity: Isolation from small intestine.Science 169, 1217, 1218.

    PubMed  CAS  Google Scholar 

  • Said S. I. and Faloona G. R. (1975) Elevated plasma and tissue levels of vasoactive intestinal polypeptide in the watery-diarrhea syndrome due to pancreatic bronchogenic and other tumors.N. Engl. J. Med. 293, 155–160.

    PubMed  CAS  Google Scholar 

  • Said S. I. and Porter J. C. (1979) Vasoactive intestinal polypeptide: Release into hypophyseal portal blood.Life Sci. 24, 227–230.

    PubMed  CAS  Google Scholar 

  • Said S. I., ed. (1982) Vasoactive Intestinal Polypeptide,Advances in Peptide Hormone Research, Raven, New York.

    Google Scholar 

  • Said S. I. (1984) Isolation, localization and characterization of gastrointestinal peptides.Peptides 5, 143–150.

    PubMed  CAS  Google Scholar 

  • Said S. I. (1986) Vasoactive intestinal peptide.J. Endocrinol. Invest. 9, 191–200.

    PubMed  CAS  Google Scholar 

  • Said S. I. and Mutt V. (1988) Vasoactive intestinal peptide and related peptides.Ann. NY Acad. Sci.,527.

  • Samson W. K., Bianchi R., Mogg R. J., Rivier J., Vale W., and Melin P. (1989) Oxytocin mediates the hypothalamic action of vasoactive intestinal peptide to stimulate prolactin secretion.Endocrinol. 124, 812–819.

    CAS  Google Scholar 

  • Schmid R., Schusdziarra V., and Classen M. (1988) Modulatory effect of glucose on VIP-induced gastric somatostatin release.Am. J. Physiol. 254, E756–759.

    PubMed  CAS  Google Scholar 

  • Schwartz J. P., Mocchetti I., Giorgi O., and Quach T. T. (1984) Transcriptional regulation of proenkephalin mRNA expression in striatum and adrenal medulla.J. Cell. Biochem. 8B, 110.

    Google Scholar 

  • Seylanz J., Hara H., Pinard E., Mraovitch S., and MacKenzie E. T. (1988) Effect of stimulation of the sphenopalatine ganglion on cortical blood flow in the rat.J. Cereb. Blood Flow Metab. 8, 875–878.

    Google Scholar 

  • Shaffer M. M. and Moody T. W. (1986) Autoradiographic visualization of CNS receptors for vasoactive intestinal peptide.Peptides 7, 283–288.

    PubMed  CAS  Google Scholar 

  • Shimatsu A., Kato Y., Matsushita N., Katakami H., Yanaihara N., and Imura H. (1982) Stimulation by serotonin of vasoactive intestinal polypeptide release into rat hypophysial portal blood.Endocrinol. 111, 338–340.

    CAS  Google Scholar 

  • Sibony P. A., Walcott B., McKeon C., and Jakobiec F. A. (1988) Vasoactive intestinal polypeptide and the innervation of the human lacrimal gland.Arch. Ophthalmol. 106, 1085–1088.

    PubMed  CAS  Google Scholar 

  • Silva C. M., Tully D. B., Petch L. A., Jewell C. M., and Cidlowski J. A. (1987) Application of a protein-blotting procedure to the study of human glucocorticoid receptor interactions with DNA.Proc. Natl. Acad. Sci. USA 84, 1744–1748.

    PubMed  CAS  Google Scholar 

  • Silver R., Witkovsky P., Horvath P., Alones V., and Barnstable C. J. (1988) Coexpression of opsinand VIP-like-immunoreactivity in CSF-contacting neurons of the avian brain.Cell Tissue Res. 253, 189–198.

    PubMed  CAS  Google Scholar 

  • Simonosits A., Tjórnhammar M. L., Kalman M., Cserpan I., Gafvelin G., and Bartfai T. (1988) Synthesis, cloning and expression in Escherichia coli of artificial genes coding for biologically active elongated precursors of the vasoactive intestinal polypeptide.Eur. J. Biochem. 178, 343–350.

    Google Scholar 

  • Singh H., Kumar A., Townsend C. M., Samad Z., and Singh P. (1988) A synthetic peptide, L-8-K, and its antibody both inhibit the specific binding of vasoactive intestinal peptide to hamster pancreatic cancer cells.Ann. NY Acad. Sci. 527, 679–681.

    Google Scholar 

  • Southern E. M. (1975) Detection of specific sequences among DNA fragments separated by gel electrophoresis.J. Mol. Biol. 98, 503–517.

    PubMed  CAS  Google Scholar 

  • Speigel A. M. (1987) Signal transduction by guanine binding proteins.Mol. Cell. Endocrinol. 49, 1–16.

    Google Scholar 

  • Spokes R. A., Yiangou Y., Chrysanthou B. J., Bowles M. P., and Bloom S. R. (1989) Effects of preprovasoactive intestinal polypeptide-derived peptides on net fluid flux in small intestine of anesthetized rats.Gastroenterol. 96, 327–330.

    CAS  Google Scholar 

  • Stanisz A. M., Befus D., and Bienenstock J. (1986) Differential effects of vasoactive intestinal peptide, substance P and somatostatin on immuno-globulin synthesis and proliferation by lymphocytes from Peyer’s patches, mesenteric lymph nodes and spleen.J. Immunol. 136, 152–156.

    PubMed  CAS  Google Scholar 

  • Staun-Olsen P., Fahrenkrug J., Gammeltoft S., Ottesen B., and Schousboe A. (1985) Development of binding sites for vasoactive intestinal polypeptide in mouse cerebral cortex and cultured cortical neurons.Int. J. Dev. Neurosci. 3, 609–616.

    CAS  Google Scholar 

  • Steiner D. F., Quinn P. S., Chan S. J., Marsh J., and Tager H. S. (1980) Proceedings mechanisms in the biosynthesis of proteins.Ann. NY Acad. Sci. 343, 1–16.

    PubMed  CAS  Google Scholar 

  • Stevens L. M. and Landis S. C. (1988) Developmental interactions between sweat glands and the sympathetic neurons which innervate them: Effects of delayed innervation on neurotransmitter plasticity and gland maturation.Dev. Biol. 130, 703–720.

    PubMed  CAS  Google Scholar 

  • Stone R. A., Laties A. M., Raviola E., and Wiesel T. N. (1988) Increase in retinal vasoactive polypeptide after eyelid fusion in primates.Proc. Natl. Acad. Sci. USA 85, 257–260.

    PubMed  CAS  Google Scholar 

  • Suzuki N., Hardebo J. E., and Owman C. (1988) Origins and pathways of cerebrovascular vasoactive intestinal polypeptide-positive nerves in rat.J. Cereb. Blood Flow Metab. 8, 697–712.

    PubMed  CAS  Google Scholar 

  • Svoboda M., De Neef P., Tastenoy M., and Christophe J. (1988) Molecular characteristics and evidence for internalization of vasoactive intestinal peptide (VIP) receptors in the tumoral rat-pancreatic acinar cell line AR 4-2 J.Eur. J. Biochem. 176, 707–713.

    PubMed  CAS  Google Scholar 

  • Tapia-Arancibia L. and Reichlin S. (1985) Vasoactive intestinal peptide and PHI stimulate somatostatin release from rat cerebral cortical—diencephalic cells in dispersed culture.Brain Res. 336, 67–72.

    PubMed  CAS  Google Scholar 

  • Tapia-Arancibia L., Pares-Herbute N., Astier H., Reichlin S., and Nathanson J. (1988) Adenylate cyclase activation is not sufficient to stimulate somatostatin release from dispersed cerebral cortical and diencephalic cells in glia-free cultures.Brain Res. 450, 101–110.

    PubMed  CAS  Google Scholar 

  • Tatemoto K. and Mutt V. (1980) Isolation of two novel candidate hormones using a chemical method for finding naturally occurring peptides.Nature 285, 417, 418.

    PubMed  CAS  Google Scholar 

  • Taylor D. and Pert C. B. (1979) Vasoactive intestinal polypeptide: Specific binding to rat brain membranes.Proc. Natl. Acad. Sci. USA 76, 660–664.

    PubMed  CAS  Google Scholar 

  • Thomas G. B., Cummins J. T., Griffin N., and Clarke I. J. (1988) Effect and site of action of hypothalamic neuropeptides on prolactin release in sheep.Neuroendocrinol. 48, 252–257.

    CAS  Google Scholar 

  • Thompson D. C., Altiere R. J., and Diamond L. (1988) The effects of antagonists of vasoactive intestinal peptide on nonadrenergic noncholinergic inhibitory responses in feline airways.Peptides 9, 443–447.

    PubMed  CAS  Google Scholar 

  • Tornell J., Carlsson B., and Hillensjo, T. (1988) Vasoactive intestinal peptide stimulates oocyte maturation, steroidogenesis, and cyclic adenosine 3′,5′-monophosphate production in isolated preovulatory rat follicles.Biol. Reprod. 39, 213–220.

    PubMed  CAS  Google Scholar 

  • Towbin H., Staehelin T., and Gordun J. (1979) Electrophoretic transfer of protein’s from polyacrylamide gels to nitrocellulose sheets: Procedure and some application.Proc. Natl. Acad. Sci. USA 76, 4350–4354.

    PubMed  CAS  Google Scholar 

  • Tricoli J. V., Bell G. I., and Shows T. B. (1984) The human glucagon gene is located on chromosome 2.Diabetes 33, 200–202.

    PubMed  CAS  Google Scholar 

  • Tsukada T., Fink J. S., Mandel G., and Goodman R. H. (1987) Identification of a region in the human vasoactive intestinal polypeptide gene responsible for regulation by cyclic AMP.J. Biol. Chem. 262, 8743–8747.

    PubMed  CAS  Google Scholar 

  • Tsukada T., Horovitch S. J., Moutminy M. R., Mandel G., and Goodman R. H. (1985) Structure of the human vasoactive intestinal polypeptide gene.DNA 4, 293–300.

    PubMed  CAS  Google Scholar 

  • Turner J. T., Jones S. B., and Bylund D. B. (1986) A fragment of vasoactive intestinal peptide, VIP (10–28), is an antagonist of VIP in the colon carcinoma cell line, HT29.Peptides 7, 849–854.

    PubMed  CAS  Google Scholar 

  • Turner J. T., Bollinger D. W., and Toews M. L. (1988) Vasoactive intestinal peptide receptor/adenylate cyclase system: Differences between agonist- and protein kinase C-mediated desensitization and further evidence for receptor internalization.J. Pharmacol. Exp. Ther. 247, 417–423.

    PubMed  CAS  Google Scholar 

  • Uemura Y., Sugimoto T., Kikuchi H., and Mizuno N. (1988) Possible origins of cerebrovascular nerve fibers showing vasoactive intestinal polypeptide-like immunoreactivity: An immunohistochemical study in the dog.Brain Res. 448, 98–105.

    PubMed  CAS  Google Scholar 

  • Van den Pol A. N. and Powley T. (1979) A fine-grained anatomical analysis of the role of the rat suprachiasmatic nucleus in circadian rhythms of feeding and drinking.Brain Res. 160, 307–326.

    PubMed  Google Scholar 

  • Van den Pol A. N. and Tsujimoto K. L. (1985) Neurotransmitters of the hypothalamic suprachiasmatic nucleus: Immunocytochemical analysis of 25 neuronal antigens.Neuroscience 15, 1049–1086.

    PubMed  Google Scholar 

  • Van den Pol A. N., and Gorcs T. (1986) Synaptic relationships between neurons containing vasopressin, gastrin-releasing peptide, vasoactive intestinal polypeptide, and glutamate decarboxylase immunoreactivity in the suprachiasmatic nucleus: Dual ultrastructural immunocytochemistry with gold-substituted silver peroxidase.J. Comp. Neurol. 252, 507–521.

    PubMed  Google Scholar 

  • Venugopalan C. S., Holmes E., and Pillai S. R. (1989) Blockade of NANC inhibitory tracheal response by peptide T.FASEB J. 3, A287.

    Google Scholar 

  • Vincent S. R. and Reiner P. B. (1988) A population of very small striatal neurons in the cat displays vasoactive intestinal polypeptide immunoreactivity.Neurosci. Lett. 89, 277–282.

    PubMed  CAS  Google Scholar 

  • Waelbroeck M., Robberecht P., Coy D. H., Camus J. C., Deneef P., and Christophe J. (1985) Interaction of growth hormone-releasing factor (GRF) and 14 GRF analogs with vasoactive intestinal peptide (VIP) receptors of rat pancreas. Discovery of (N-Ac-Tyr1,D-Phe2)-GRF(1–29)—NH2 as a VIP antagonist.Endocrinol. 116, 2643–2649.

    CAS  Google Scholar 

  • Wang Y.-Y. and Aghajanian G. K. (1988) VIP excitation of locus coeruleus neurons: Evidence for a G-protein-mediated inward current.Soc. Neurosci. Abs. 14, 147 (Abs. 59.9).

    Google Scholar 

  • Waschek J. A. and Eiden L. E. (1988) Calcium requirements for barium stimulation of enkephalin and vasoactive intestinal biosynthesis in adrenomedullary chromaffin cells.Neuropeptides 11, 39–45.

    PubMed  CAS  Google Scholar 

  • Waschek J. A., Hsu C.-M., and Eiden L. E. (1988) Lineage-specific regulation of the vasoactive intestinal peptide gene in neuroblastoma cells is conferred by 5.2 kilobases of 5′-flanking sequence.Proc. Natl. Acad. Sci. USA 85, 9547–9551.

    PubMed  CAS  Google Scholar 

  • Wattchow D. A., Furness J. B., and Costa M. (1988) Distribution and coexistence of peptides in nerve fibers of the external muscle of the human gastrointestinal tract.Gastroenterol. 95, 32–41.

    CAS  Google Scholar 

  • Watts A. G. and Swanson L. W. (1987) Efferent projections of the suprachiasmatic nucleus: II. Studies using retrograde transport of fluorescent dyes and simultaneous peptide immunocytochemistry in the rat.J. Comp. Neurol. 258, 230–252.

    PubMed  CAS  Google Scholar 

  • Weinstein J., Pope M., Schmidt R., and Seroussi R. (1988) Neuropharmacologic effects of vibration on the dorsal root ganglion. An animal model.Spine 13, 521–525.

    PubMed  CAS  Google Scholar 

  • Werner H., Koch Y., Fridkin M., Fahrenkrug J., and Gozes I. (1985) Detection of elevated amounts of VIP in milk.Biochem. Biophys. Res. Commun. 136, 228–232.

    Google Scholar 

  • Werner H., Koch Y., Baldino F., Jr., and Gozes I. (1988) Estrogen regulation of somatostatin mRNA in the rat hypothalamus.J. Biol. Chem. 263, 7666–7671.

    PubMed  CAS  Google Scholar 

  • White J. D. and Gall C. M. (1987) Differential regulation of neuropeptide and proto-oncogene mRNA content in the hippocampus following recurrent seizures.Mol. Brain Res. 3, 21–29.

    CAS  Google Scholar 

  • Wiik P. (1988) Homologous regulation of adenylate cyclase-coupled receptors for vasoactive intestinal peptide (VIP) on human mononuclear leukocytes.Reg. Pept. 20, 323–333.

    CAS  Google Scholar 

  • Wynick D., Williams S. J., and Bloom S. R. (1988) Symptomatic secondary hormone syndromes in patients with established malignant pancreatic endocrine tumors.N. Engl. J. Med. 319, 605–607.

    PubMed  CAS  Google Scholar 

  • Yada T. and Okada Y. (1984) Electrical activity of an intestinal epithelial cell line; hyperpolarizing responses to intestinal secretagogues.J. Membrane Biol. 77, 33–44.

    CAS  Google Scholar 

  • Yaksh T. L., Michener S. R., Bailey J. E., Harty G. J., and Lucas D. L. (1988) Survey of distribution of substance P, vasoactive intestinal polypeptide, cholecystokinin, neurotensin, Met-enkephalin, bombesin and PHI in the spinal cord of cat, dog, sloth and monkey.Peptides 9, 357–372.

    PubMed  CAS  Google Scholar 

  • Yamagami T., Ohsawa K., Nishizawa M., Inoue C., Gotoh E., Yanaihara N., Yamamoto H., and Okamoto H. (1988) Complete nucleotide sequence of human vasoactive intestinal peptide/PHM-27 gene and its inducible promoter.Ann NY Acad. Sci. 527, 87–102.

    PubMed  CAS  Google Scholar 

  • Yu G., Grant S., and Glazer R. I. (1988) Association of p93c-fes tyrosine protein kinase with granulocytic/monocytic differentiation and resistance to differentiating agents in HL-60 leukemia cells.Mol. Pharmacol. 33, 384–388.

    PubMed  CAS  Google Scholar 

  • Yuwiler A. and Wetterberg L. (1989) Peptide T does not affect induction of pinealN-acetyltransferase by vasoactive intestinal peptide.Regul. Pept. 25, 69–73.

    PubMed  CAS  Google Scholar 

  • Zurier R. B., Kozma M., Sinnett-Smith J., and Rozengurt E. (1988) Vasoactive intestinal peptide synergistically stimulate DNA synthesis in mouse 3T3 cells: Role of cAMP, Ca2+ and protein kinase C.Exp. Cell Res. 176, 155–161.

    PubMed  CAS  Google Scholar 

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Gozes, I., Brenneman, D.E. VIP: Molecular biology and neurobiological function. Mol Neurobiol 3, 201–236 (1989). https://doi.org/10.1007/BF02740606

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