Abstract.
Despite the wealth of information on voltage-gated calcium channels, little is known about low voltage-activated, T-type channels. The ability of the antihypertensive drug mibefradil to selectively block T-type channels has generated much interest in their structure, physiology and pharmacology. This review covers the cloning of a new family of calcium channels, their putative structure, the electrophysiological evidence that demonstrated that these complementary DNAs encoded low voltage-activated, T-type channels, the tissue expression of these genes, and concludes with a discussion of their possible physiological roles.
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Received 12 May 1999; received after revision 12 July 1999; accepted 14 July 1999
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Perez-Reyes, E. Three for T: molecular analysis of the low voltage-activated calcium channel family. CMLS, Cell. Mol. Life Sci. 56, 660–669 (1999). https://doi.org/10.1007/s000180050460
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DOI: https://doi.org/10.1007/s000180050460