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Nuclear factor-κB: its role in health and disease

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Abstract

Nuclear factor-κB (NF-κB) is a major transcription factor that plays an essential role in several aspects of human health including the development of innate and adaptive immunity. The dysregulation of NF-κB is associated with many disease states such as AIDS, atherosclerosis, asthma, arthritis, cancer, diabetes, inflammatory bowel disease, muscular dystrophy, stroke, and viral infections. Recent evidence also suggests that the dysfunction of NF-κB is a major mediator of some human genetic disorders. Appropriate regulation and control of NF-κB activity, which can be achieved by gene modification or pharmacological strategies, would provide a potential approach for the management of NF-κB related human diseases. This review summarizes the current knowledge of the physiological and pathophysiological functions of NF-κB and its possible role as a target of therapeutic intervention

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Abbreviations

aly :

Alymphoplasia

HIV :

Human immunodeficiency virus

IKK :

IκB kinase

IL :

Interleukin

MEKK :

Mitogen-activated protein kinase kinase kinase

NEMO :

Nuclear factor-κB essential modulator

NF-κB :

Nuclear factor-κB

NIK :

Nuclear factor-κB inducing kinase

TNF :

Tumor necrosis factor

VCAM :

Vascular cell adhesion molecules

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Acknowledgements

This work was supported by Muscular Dystrophy Association grants (to A.K. and A.M.B.) and RO1 grant HL63134 (to A.M.B.). Support was also provided in part by the Clayton Foundation for Research (to B.B.A.), United States Department of Defense Army Breast Cancer Research Program grant BC010610 (to B.B.A.), a PO1 grant (CA91844) from the National Institutes of Health on Lung Cancer Chemoprevention (to B.B.A.) and a P50 Head and Neck SPORE grant (P50-CA97007) from the National Institutes of Health (to B.B.A.).

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Correspondence to Ashok Kumar or Bharat B. Aggarwal.

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Kumar, A., Takada, Y., Boriek, A.M. et al. Nuclear factor-κB: its role in health and disease. J Mol Med 82, 434–448 (2004). https://doi.org/10.1007/s00109-004-0555-y

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