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Successful treatment of a complicated case of neuroleptic malignant syndrome

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Abstract.

Neuroleptic malignant syndrome (NMS) is a life-threatening reaction often related to neuroleptic drugs, characterized by rigidity, hyperthermia, altered consciousness, and fluctuating blood pressure. We present a case of NMS that followed a doubled oral dose of a drug compound: tranylcypromine sulfate, a monoamine oxidase inhibitor, and trifluoperazine (neuroleptic). The case was complicated by rhabdomyolisis and disseminated intravascular coagulation. It was treated successfully with dantrolene sodium and generous fluid therapy without using neuromuscular blocking agents or dopamine agonists.

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Authors and Affiliations

  1. Intensive Care Unit, M.G. Vannini Hospital, Via A. Bullicante no. 4, 00177 Rome, Italy, Italy

    A. Lappa, M. Podestà, O. Capelli, A. Castagna & G. Di Placido

  2. Intensive Care Unit, University of Rome La Sapienza, Rome, Italy, Italy

    D. Alampi & F. Semeraro

Authors
  1. A. Lappa
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  2. M. Podestà
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  3. O. Capelli
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  4. A. Castagna
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  5. G. Di Placido
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  6. D. Alampi
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  7. F. Semeraro
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Lappa, A., Podestà, M., Capelli, O. et al. Successful treatment of a complicated case of neuroleptic malignant syndrome. Intensive Care Med 28, 976–977 (2002). https://doi.org/10.1007/s00134-002-1241-6

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  • DOI: https://doi.org/10.1007/s00134-002-1241-6

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