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Regulation of transient receptor potential (TRP) channels by phosphoinositides

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Abstract

This review summarizes the modulation of transient receptor potential (TRP) channels, by phosphoinositides. TRP channels are characterized by polymodal activation and a surprising complexity of regulation mechanisms. Possibly, most if not all TRP channels are modulated by phosphoinositides. Modulation by phosphatidylinositol 4,5-biphosphate (PIP2) has been shown in detail for TRP vanilloid (TRPV) 1, TRPV5, TRP melastatin (TRPM) 4, TRPM5, TRPM7, TRPM8, TRP polycystin 2, and the Drosophila TPR-like (TRPL) channels. This review describes mechanisms of modulation of TRP channels mainly by PIP2 and discusses some future challenges of this fascinating topic.

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Acknowledgment

We thank all members or our laboratories for always-helpful discussions. This work was supported by the Human Frontiers Science Programme (HFSP Research Grant Ref. RGP 32/2004), the Belgian Federal Government, the Flemish Government, the Onderzoeksraad KU Leuven (GOA 99/07, F.W.O. G.0214.99, F.W.O. G. 0136.00; F.W.O. G.0172.03, Interuniversity Poles of Attraction Program, Prime Ministers Office (IUAP; BN), and the American Heart Association, the Alexander and Alexandrine Sinsheimer Foundation, and the UMDNJ Foundation (TR).

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Authors and Affiliations

  1. Department of Pharmacology and Physiology, University of Medicine and Dentistry of New Jersey—New Jersey Medical School, Newark, NJ, 07103, USA

    Tibor Rohacs

  2. Department of Molecular Cell Biology, Division of Physiology, Laboratory of Ion Channel Research, KU Leuven, Campus Gasthuisberg, Herestraat 49, bus 802, 3000, Leuven, Belgium

    Bernd Nilius

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  2. Bernd Nilius
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Correspondence to Tibor Rohacs.

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Rohacs, T., Nilius, B. Regulation of transient receptor potential (TRP) channels by phosphoinositides. Pflugers Arch - Eur J Physiol 455, 157–168 (2007). https://doi.org/10.1007/s00424-007-0275-6

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  • DOI: https://doi.org/10.1007/s00424-007-0275-6

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