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Antidepressant-like effect of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist in the olfactory bulbectomized rats

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Summary.

 Using the olfactory bulbectomy model of depression, we examined the antidepressant-like activity of 2-methyl-6-(phenylethynyl)-pyridine (MPEP) in rats. Bulbectomized rats required a significantly greater number of trials to acquire the response similar to sham-operated controls in the passive avoidance model. Both the prolonged (but not acute) treatment with MPEP and with antidepressant drug-desipramine restored the learning deficit. The results indicate that the prolonged blockade of mGlu5 receptors exerts antidepressant-like effects in rats.

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Authors and Affiliations

  1.  Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland, , , , , , PL

    J. M. Wieronska, B. Szewczyk, P. Branski, A. Palucha & A. Pilc

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  1. J. M. Wieronska
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  2. B. Szewczyk
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  3. P. Branski
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  4. A. Palucha
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  5. A. Pilc
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Received July 2, 2001 Accepted August 6, 2001 Published online June 26, 2002

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Wieronska, J., Szewczyk, B., Branski, P. et al. Antidepressant-like effect of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist in the olfactory bulbectomized rats. Amino Acids 23, 213–216 (2002). https://doi.org/10.1007/s00726-001-0131-5

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  • DOI: https://doi.org/10.1007/s00726-001-0131-5

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