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Reviews of Physiology, Biochemistry and Pharmacology pp 93–109Cite as

Pasteurella multocida toxin as a tool for studying Gq signal transduction

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Part of the book series: Reviews of Physiology, Biochemistry and Pharmacology ((REVIEWS,volume 152))

Abstract

Pasteurella multocida toxin (PMT) stimulates and subsequently uncouples phospholipase C (PLC) signal transduction through its selective action on the Gαq subunit. This review summarizes what is currently known about the molecular action of PMT on Gq and the resulting cellular effects. Examples are presented illustrating the use of PMT as a powerful tool for dissecting the molecular mechanisms involving pertussis toxin (PT)-insensitive heterotrimeric G proteins.

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  1. Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA

    B. A. Wilson & M. Ho

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Wilson, B.A., Ho, M. (2004). Pasteurella multocida toxin as a tool for studying Gq signal transduction. In: Reviews of Physiology, Biochemistry and Pharmacology. Reviews of Physiology, Biochemistry and Pharmacology, vol 152. Springer, Berlin, Heidelberg. https://doi.org/10.1007/s10254-004-0032-6

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