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Marine actinomycetes as a source of novel secondary metabolites

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Abstract

A set of 600 actinomycetes strains which were isolated from marine sediments from various sites in the Pacific and Atlantic Oceans were screened for the production of bioactive secondary metabolites. Marine streptomycete strains were found to be producers of well known chemically diverse antibiotics isolated from terrestrial streptomycetes, as in the case of marine Micromonospora strains. New marine members of the rare genus Verrucosispora seem to be a promising source for novel bioactive secondary metabolites as shown in the case of the abyssomicin producing strain AB-18-032.

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References

  • M. Bertasso M. Holzenkämpfer A. Zeeck E. Stackebrandt W. Beil H.-P. Fiedler (2003) ArticleTitleRipromycin and other polycyclic macrolactams from Streptomyces sp. Tü 6239: taxonomy, fermentation, isolation and biological properties J. Antibiot. 56 364–371 Occurrence Handle1:CAS:528:DC%2BD3sXjsVKiurg%3D Occurrence Handle12817810

    CAS  PubMed  Google Scholar 

  • B. Bister D. Bischoff M. Ströbele J. Riedlinger A. Reicke F. Wolter A.T. Bull H. Zähner H.-P. Fiedler R.D. Süssmuth (2004) ArticleTitleAbyssomicin C – a polycyclic antibiotic from a marine Verrucosispora strain as an inhibitor of the p-aminobenzoic acid/tetrahydrofolate biosynthesis pathway Angew. Chem. Int. Ed. 43 2574–2576 Occurrence Handle1:CAS:528:DC%2BD2cXkt1eis70%3D

    CAS  Google Scholar 

  • J.W. Blunt B.R. Copp M.H.G. Munro P.T. Northcote M.R. Prinsep (2003) ArticleTitleMarine natural products Nat. Prod. Rep. 20 1–48 Occurrence Handle1:CAS:528:DC%2BD3sXisVKls7w%3D Occurrence Handle12636082

    CAS  PubMed  Google Scholar 

  • J.W. Blunt B.R. Copp M.H.G. Munro P.T. Northcote M.R. Prinsep (2004) ArticleTitleMarine natural products Nat. Prod. Rep. 21 1–49 Occurrence Handle1:CAS:528:DC%2BD2cXisFWgtLs%3D Occurrence Handle15039834

    CAS  PubMed  Google Scholar 

  • P.F.B. Brandao M. Torimura R. Kurane A.T. Bull (2002) ArticleTitleDereplication for biotechnology screening: PyMS analysis and PCR-RFLP-SSCP (PRS) profiling of 16S rRNA genes of marine and terrestrial actinomycetes Appl. Microbiol. Biotechnol. 58 77–83 Occurrence Handle1:CAS:528:DC%2BD38XhtVSitLw%3D Occurrence Handle11833532

    CAS  PubMed  Google Scholar 

  • J.A. Colquhoun S.C. Heald L. Li J. Tamaoka C. Kato K. Horikoshi A.T. Bull (1998) ArticleTitleTaxonomy and biotransformation activities of some deep-sea actinomycetes Extremophiles 2 269–277 Occurrence Handle1:CAS:528:DyaK1cXmtVOqtLw%3D Occurrence Handle9783174

    CAS  PubMed  Google Scholar 

  • D.J. Faulkner (2000) ArticleTitleHighlights of marine natural products chemistry (1972–1999) Nat. Prod. Rep. 17 1–6 Occurrence Handle1:CAS:528:DC%2BD3cXltVKltA%3D%3D Occurrence Handle10714897

    CAS  PubMed  Google Scholar 

  • D.J. Faulkner (2000) ArticleTitleMarine pharmacology Antonie van Leeuwenhoek 77 135–145 Occurrence Handle1:CAS:528:DC%2BD3cXivFWku7s%3D Occurrence Handle10768472

    CAS  PubMed  Google Scholar 

  • R.H. Feling G.O. Buchanan T.J. Mincer C.A. Kauffman P.R. Jensen W. Fenical (2003) ArticleTitleSalinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial sourcea marine bacterium of the new genus Salinospora Angew. Chem. Int. Ed. 42 355–357 Occurrence Handle1:CAS:528:DC%2BD3sXhtVWqsbY%3D

    CAS  Google Scholar 

  • H.-P. Fiedler (1993) ArticleTitleBiosynthetic capacities of actinomycetes. 1. Screening for secondary metabolites by HPLC and UV-visible absorbance spectral libraries Nat. Prod. Lett. 2 119–128 Occurrence Handle1:CAS:528:DyaK2cXis1Gns7g%3D

    CAS  Google Scholar 

  • B. Haefner (2003) ArticleTitleDrugs from the deep: marine natural products as drug candidates Drug Discovery Today 8 536–544 Occurrence Handle1:CAS:528:DC%2BD3sXkvVCntbw%3D Occurrence Handle12821301

    CAS  PubMed  Google Scholar 

  • K. Jomon Y. Kuroda M. Ajisaka H. Sakai (1972) ArticleTitleA new antibiotic, ikarugamycin J. Antibiot. 25 271–280 Occurrence Handle1:CAS:528:DyaE38XksF2quro%3D Occurrence Handle4625358

    CAS  PubMed  Google Scholar 

  • H. Kang P.R. Jensen W. Fenical (1996) ArticleTitleIsolation of microbial antibiotics from a marine ascidian of the genus Didemnum J. Org. Chem. 61 1543–1546 Occurrence Handle1:CAS:528:DyaK28XosVKnsA%3D%3D

    CAS  Google Scholar 

  • N. Miyairi H.I. Sakai T. Konomi H. Imanaka (1976) ArticleTitleEnterocin, a new antibiotic. Taxonomy, isolation and characterization J. Antibiot. 29 227–235 Occurrence Handle1:CAS:528:DyaE28XksVCrtrg%3D Occurrence Handle770404

    CAS  PubMed  Google Scholar 

  • M.H.G. Munro J.W. Blunt E.J. Dumdei S.J.H. Hickford R.E. Lill S. Li C.N. Battershill A.R. Duckworth (1999) ArticleTitleThe discovery and development of marine compounds with pharmaceutical potential J. Biotechnol. 70 15–25 Occurrence Handle1:CAS:528:DyaK1MXjs1Shsr0%3D Occurrence Handle10412202

    CAS  PubMed  Google Scholar 

  • H. Ohkuma S. Kobaru 1996 Compound produced by a strain of Micromonospora Bristol-Myers Squibb Co U.S. Pat. 5,541,181, July 30

  • M.K. Renner Y.-C. Shen X.-C. Cheng P.R. Jensen W. Frankmoelle C.A. Kauffman W. Fenical E. Lobkovsky J. Clardy (1999) ArticleTitleCyclomarins A-C, new antiinflammatory cyclic peptides produced by a marine bacterium (Streptomyces sp.) J. Am. Chem. Soc. 121 11273–11276 Occurrence Handle1:CAS:528:DyaK1MXnsFymsbg%3D

    CAS  Google Scholar 

  • H. Rheims P. Schumann M. Rohde E. Stackebrandt (1998) ArticleTitleVerrucosispora gifhornensis gen. nov., sp. nov., a new member of the actinobacterial family Micromonosporaceae Int. J. Syst. Bacteriol. 48 1119–1127 Occurrence Handle10.1099/00207713-48-4-1119 Occurrence Handle1:CAS:528:DyaK1cXns12rt7o%3D Occurrence Handle9828414

    Article  CAS  PubMed  Google Scholar 

  • J. Riedlinger A. Reicke H. Zähner B. Krismer A.T. Bull L.A. Maldonado A.C. Ward M. Goodfellow B. Bister D. Bischoff R.D. Süssmuth H.-P. Fiedler (2004) ArticleTitleAbyssomicins, inhibitors of the para-aminobenzoic acid pathway produced by the marine Verrucosispora strain AB-18-032 J. Antibiot. 57 271–279 Occurrence Handle1:CAS:528:DC%2BD2cXjslCgs70%3D Occurrence Handle15217192

    CAS  PubMed  Google Scholar 

  • F. Romero F. Espliego J.P. Baz T.G. de Quesada D. Grávalos F. la Calle J.L. Fernández-Puentes (1997) ArticleTitleThiocoralinea new depsipeptide with antitumor activity produced by a marine Micromonospora. I. Taxonomy, fermentation, isolation, and biological activities J. Antibiot. 50 734–737 Occurrence Handle1:STN:280:DyaK1c%2FisFSqsA%3D%3D Occurrence Handle9360617

    CAS  PubMed  Google Scholar 

  • C.E. Salomon N.A. Magarvey D.H. Sherman (2004) ArticleTitleMerging the potential of microbial genetics with biological and chemical diversity: an ever brighter future for marine natural product drug discovery Nat. Prod. Rep. 21 105–121 Occurrence Handle1:CAS:528:DC%2BD2cXisFWgtLc%3D Occurrence Handle15039838

    CAS  PubMed  Google Scholar 

  • J.E.M. Stach L.A. Maldonado A.C. Ward M. Goodfellow A.T. Bull (2003a) ArticleTitleNew primers specific for taxa assigned to the class Actinobacteria: application to marine and terrestrial environments Environ. Microbiol. 5 828–841 Occurrence Handle1:CAS:528:DC%2BD3sXos1Clt7c%3D

    CAS  Google Scholar 

  • J.E.M. Stach L.A. Maldonado D.G. Masson A.C. Ward M. Goodfellow A.T. Bull (2003b) ArticleTitleStatistical approaches to estimating bacterial diversity in marine sediments Appl. Environ. Microbiol. 69 6189–6200 Occurrence Handle1:CAS:528:DC%2BD3sXotlKjsLo%3D

    CAS  Google Scholar 

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Correspondence to Hans-Peter Fiedler.

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Fiedler, HP., Bruntner, C., Bull, A. . et al. Marine actinomycetes as a source of novel secondary metabolites. Antonie Van Leeuwenhoek 87, 37–42 (2005). https://doi.org/10.1007/s10482-004-6538-8

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  • DOI: https://doi.org/10.1007/s10482-004-6538-8

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