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Anatomy of the Hypophysiotropic Somatostatinergic and Growth Hormone-releasing Hormone System Minireview

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Abstract

The central control of growth hormone (GH) secretion from the pituitary gland is ultimately achieved by the interaction between two hypothalamic neurohormones, somatostatin which inhibits and growth hormone-releasing hormone (GHRH) which stimulates GH release. The regulation of the somatostatin and GHRH release from the hypothalamus is regulated by a range of other neuropeptides, neurotransmitters, neurohormones. In this mini review we attempt to provide a short summary covering the anatomy and chemical characteristics of the various cell populations regulating GH secretion as a tribute to Miklós Palkovits who pioneered the field of functional neuroanatomy of hypothalamic networks.

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Authors and Affiliations

  1. Department of Pediatrics, VU University Medical Center, Amsterdam, The Netherlands

    Mariann Fodor

  2. Department of Anatomy and Embryology, Leiden University Medical Center, Leiden, The Netherlands

    Mariann Fodor

  3. Institut Necker, Paris, France

    Claude Kordon

  4. INSERM-Université Paris 5 UMR, 549, Paris, France

    Jacques Epelbaum

  5. Department of Anatomy and Embryology, Leiden University Medical Center, 9602, 2300 RC, Leiden, The Netherlands

    Mariann Fodor

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  1. Mariann Fodor
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  2. Claude Kordon
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  3. Jacques Epelbaum
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Correspondence to Mariann Fodor.

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Special Issue Dedicated to Miklós Palkovits.

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Fodor, M., Kordon, C. & Epelbaum, J. Anatomy of the Hypophysiotropic Somatostatinergic and Growth Hormone-releasing Hormone System Minireview. Neurochem Res 31, 137–143 (2006). https://doi.org/10.1007/s11064-005-9017-3

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