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Vectorial Ligand Transport Through Mammalian Choroid Plexus

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ABSTRACT

In the last decade, there has been substantial progress in understanding vectorial ligand transport through rodent and human choroid plexus (CP), the locus of the blood-CSF interface. In this Review, we enumerate the experimental data required to establish vectorial transport through CP and describe transporters involved in vectorial transport across CP. We also note how these transporters differ from those at the blood-brain barrier. The ligand (substrate) examples presented are methyltetrahydrofolate, methotrexate, leukotriene C4, nucleosides, thiamine monophosphate, prostaglandins, and digoxin. Our focus is on more definitive experiments, including animal and human transporter “knock-outs.” Finally, we discuss the neurochemical implications of vectorial transport through CP and the clinical implications of transporter polymorphisms and knockouts. Examples include descriptions of how vectorial transport through the CP for several micronutrients (e.g., methyltetrahydrofolate) nourishes the brain and how knowledge of CP vectorial transport can lead to important treatments.

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ACKNOWLEDGEMENTS

The authors wish to thank Michiko Spector for her aid in the preparation of the manuscript, and Julie Johanson and Arthur Messier for their assistance with graphics.

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Authors and Affiliations

  1. Department of Medicine, Robert Wood Johnson Medical School, Piscataway, New Jersey, USA

    Reynold Spector

  2. Department of Neurosurgery, Alpert Medical School at Brown University, Providence, Rhode Island, USA

    Conrad E. Johanson

  3. Department of Neurosurgery, Brown Medical School, 593 Eddy Street, Providence, Rhode Island, 02903, USA

    Conrad E. Johanson

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  1. Reynold Spector
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  2. Conrad E. Johanson
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Correspondence to Conrad E. Johanson.

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Spector, R., Johanson, C.E. Vectorial Ligand Transport Through Mammalian Choroid Plexus. Pharm Res 27, 2054–2062 (2010). https://doi.org/10.1007/s11095-010-0162-2

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  • DOI: https://doi.org/10.1007/s11095-010-0162-2

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