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Group I Metabotropic Glutamate Receptors: A Role in Neurodevelopmental Disorders?

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Abstract

Group I metabotropic glutamate receptors (mGlu1 and mGlu5) are coupled to polyphosphoinositide hydrolysis and are involved in activity-dependent forms of synaptic plasticity, both during development and in the adult life. Group I mGlu receptors can also regulate proliferation, differentiation, and survival of neural stem/progenitor cells, which further support their role in brain development. An exaggerated response to activation of mGlu5 receptors may underlie synaptic dysfunction in Fragile X syndrome, the most common inherited form of mental retardation. In addition, group I mGlu receptors are overexpressed in dysplastic neurons of focal cortical dysplasia and hemimegaloencephaly, which are disorders of cortical development associated with chronic epilepsy. Drugs that block the activity of group I mGlu receptors (in particular, mGlu5 receptors) are potentially helpful for the treatment of Fragile X syndrome and perhaps other neurodevelopmental disorders.

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Authors and Affiliations

  1. Institute of Neurological Sciences, National Research Council (CNR), vl. Regina Margherita 6, 95123, Catania, Italy

    Maria Vincenza Catania & Simona D’Antoni

  2. Laboratory of Molecular and Cellular Neurobiology, Oasi Institute for Research on Mental Retardation and Brain Aging (IRCCS), Troina, Enna, Italy

    Maria Vincenza Catania & Carmela Maria Bonaccorso

  3. Department of (Neuro)Pathology, Academisch Medisch Centrum, 1105 AZ, Amsterdam, The Netherlands

    Eleonora Aronica

  4. The Picower Institute, HHMI, Massachusetts Institute of Technology, Cambridge, MA, USA

    Mark F. Bear

  5. Department of Physiology and Pharmacology “V. Erspamer”, University of Rome “La Sapienza”, Rome, Italy

    Ferdinando Nicoletti

  6. INM Neuromed, Pozzilli, Isernia, Italy

    Ferdinando Nicoletti

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  1. Maria Vincenza Catania
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  2. Simona D’Antoni
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  3. Carmela Maria Bonaccorso
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  4. Eleonora Aronica
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  5. Mark F. Bear
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  6. Ferdinando Nicoletti
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Correspondence to Maria Vincenza Catania.

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Catania, M.V., D’Antoni, S., Bonaccorso, C.M. et al. Group I Metabotropic Glutamate Receptors: A Role in Neurodevelopmental Disorders?. Mol Neurobiol 35, 298–307 (2007). https://doi.org/10.1007/s12035-007-0022-1

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