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Group I mGluRs and Long-Term Depression: Potential Roles in Addiction?

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Abstract

Addiction is an enormous societal problem. A number of recent studies have focused on adaptations at glutamatergic synapses that may play a role in the behavioral responses to drugs of abuse. These studies have largely focused on NMDA receptor-dependent forms of synaptic plasticity such as NMDA receptor-dependent long-term potentiation (LTP) and long-term depression (LTD). A growing body of evidence, however, suggests that metabotropic glutamate receptors (mGluRs) also play important roles in the behavioral responses to drugs of abuse and participate in producing synaptic plasticity at glutamate synapses. In this review, we focus first on the evidence supporting a role for mGluRs in addiction and then on the properties of mGluR-dependent forms of synaptic plasticity, focusing in particular on Gq-linked receptor-induced LTD.

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Acknowledgements

This work was supported by NIAAA and NIDA.

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Authors and Affiliations

  1. Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Room 724B, RRB, Nashville, TN, 37232-0615, USA

    Brad A. Grueter & Danny G. Winder

  2. Neuroscience Graduate Program, Vanderbilt University School of Medicine, Nashville, TN, 37232-0615, USA

    Zoé A. McElligott & Danny G. Winder

  3. Vanderbilt Brain Institute, Vanderbilt University School of Medicine, Nashville, TN, 37232-0615, USA

    Danny G. Winder

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  1. Brad A. Grueter
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  2. Zoé A. McElligott
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  3. Danny G. Winder
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Correspondence to Danny G. Winder.

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Grueter, B.A., McElligott, Z.A. & Winder, D.G. Group I mGluRs and Long-Term Depression: Potential Roles in Addiction?. Mol Neurobiol 36, 232–244 (2007). https://doi.org/10.1007/s12035-007-0037-7

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  • DOI: https://doi.org/10.1007/s12035-007-0037-7

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