Vascular endothelium: An integrator of pathophysiologic stimuli in atherosclerosis

doi:10.1016/0002-9149(95)80016-L

The American Journal of Cardiology

Volume 75, Issue 6, Supplement 1, 23 February 1995, Pages 67B-70B

https://doi.org/10.1016/0002-9149(95)80016-L Get rights and content

Abstract

Vascular endothelium, the single-cell-thick lining of the cardiovascular system, is an important functional component of the blood vessel wall, actively participating in normal vascular physiology as well as the pathogenesis of vascular diseases such as atherosclerosis. The localized modulation of vascular endothelium to a non-adaptive functional state can be termed “endothelial dysfunction.” This article provides a brief overview of endothelial dysfunction, especially as it relates to mononuclear leukocyte recruitment during atherosclerotic lesion formation. Potential diagnostic and therapeutic implications are also considered.

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Vascular endothelium: An integrator of pathophysiologic stimuli in atherosclerosis

Abstract

Cell

Cell

Der ateromatose Prozess der Arterien

Wien Med Wochenschr

The pathogenesis of atherosclerosis: a perspective for the 1990's

Nature

Cytokines and endothelial cell biology

Physiol Rev

The pathogenesis of atherosclerosis: atherogenesis and inflammation

Lab Invest

Dietary induced atherogenesis in swine

Am J Pathol

Studies on the pathogenesis of atherosclerosis. 1. Adhesion and emigration of mononuclear cells in the aorta of hypercholesterolemic rats

Am J Pathol

Studies of hypercholesterolemia in the nonhuman primates. I. Changes that lead to fatty streak formation

Arteriosclerosis

Involvement of the immune system in human atherogenesis: current knowledge and unanswered questions

Lab Invest