Biochemical and Biophysical Research Communications
Calmodulin and cell proliferation
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Calmodulin downregulation in conditional knockout HeLa cells inhibits cell migration
2021, Archives of Biochemistry and BiophysicsProteomics analysis of G protein-coupled receptor kinase 4-inhibited cellular growth of HEK293 cells
2019, Journal of ProteomicsCitation Excerpt :Calmodulin (CALM1) is the key protein of the calcium signaling pathway (Ca2+/CALM1 complex), which regulates the cell cycle by regulating G1/S and G2/M transitions and by regulating the expression of CDK1, CDK2, cyclin B, and CDK4-cyclinD1 [44,46]. CALM1 also plays a cascading role in cell proliferation and survival [42,43]. Decreasing CALM1 prevented cells from growing, which is in accordance with cell cycle arrest [42,43,46,47].
Calcium signaling and cell cycle: Progression or death
2018, Cell CalciumThe many faces of calmodulin in cell proliferation, programmed cell death, autophagy, and cancer
2014, Biochimica et Biophysica Acta - Molecular Cell ResearchCitation Excerpt :In agreement with the above described observations, the action of CaM antagonists in non-tumor cells, such as the CHO-K1 cells [151,162], or in tumorigenic cells, such as avian sarcoma virus (ASV)-transformed kidney cells [163], melanoma B16 cells [164] or human breast cancer MCF-7 cells [165], is due to an arrest of the cell cycle at the G1 phase, indicative of the prominent role that CaM plays at the G1/S transition. However, when the CaM antagonist was added much later, during the S phase, the cell cycle was arrested at the late G2 or early M phases [150], further pointing to the involvement of CaM in later phases of the cell cycle (Fig. 4). Not surprisingly, due to its multiple functions CaM is normally located in many cellular compartments including the cytosol, attached to membranes, inside the nucleus, and in different organelles, as demonstrated by sub-cellular fractionation and by expressing fluorescently-labeled CaM species in cultured living cells.
Localization of calmodulin and calmodulin-like protein and their functions in biomineralization in P.fucata
2008, Progress in Natural ScienceOverexpression of calmodulin induces cardiac hypertrophy by a calcineurin-dependent pathway
2005, Biochemical and Biophysical Research CommunicationsCitation Excerpt :Furthermore, overexpression of CaM in cultured cardiomyocytes increased the activity of the ANF gene promoter, and this effect was again inhibited by FK506. Both Ca2+ and CaM are thought to play important roles in the growth of mammalian cells in culture [20–23]. Calcium has also been implicated as a mediator of hypertrophic responses in cardiac myocytes [24].