Biochemical and Biophysical Research Communications
Biosynthesis of leukotoxin, 9, 10-epoxy-12 octadecenoate, by leukocytes in lung lavages of rat after exposure to hyperoxia
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2021, Journal of Allergy and Clinical ImmunologyCitation Excerpt :This combination of LA- and AA-derived lipid mediators may come from neutrophil (12,13-EpOME [isoleukotoxin],38 9,10-DiHOME [leukotoxin diol],39 and 13-HODE40) and platelet (TxB2 and 12-HETE41) sources. 12,13-EpHOME, generated by CYP450 from LA during oxidative burst, uncouples mitochondrial respiration42 and is present in the lavage fluid of acute respiratory distress syndrome.43 9,10-diHOME is generated from 9(10)-EpOME (leukotoxin) by soluble epoxide hydrolase in neutrophils.39
Cytochrome P450-derived linoleic acid metabolites EpOMEs and DiHOMEs: a review of recent studies
2020, Journal of Nutritional BiochemistryCitation Excerpt :Rodent skin samples from experimentally burned animals were extracted, and a single lipid was isolated [88] that was eventually identified as 9,10-EpOME by gas chromatography/mass spectrometry and nuclear magnetic resonance analysis [102]. This metabolite was named “leukotoxin” since it was presumed that these metabolites were produced in the leukocytes [31,32,71]. The same metabolites were found to be produced by neutrophils in the lung after hyperoxic exposure [71].
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2016, Prostaglandins and Other Lipid MediatorsCitation Excerpt :Together, these results support a potential role of EpOMEs in the pathology of obesity. EpOMEs have been shown to have a large array of detrimental effects on health, and are termed as “leukotoxins” since leukocytes have been shown to be a major cell type to produce EpOMEs [31–34]. Previous studies have shown that EpOMEs have an array of detrimental effects on health, inducing chemotaxis, inflammation, cardiovascular disease and pulmonary diseases [17–26].