Vascular relaxation mediated by hydroxylamines and oximes: Their conversion to nitrites and mechanism of endothelium dependent vascular relaxation

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Abstract

Hydroxylamines (RNHOH) and oximes (RNOH) relax rat aortic rings independent of the presence of the endothelium. The relaxation is inhibited by methylene blue, an inhibitor of soluble guanylate cyclase and by hemoglobin, an inhibitor of the endothelium dependent relaxing factor (EDRF). Both the oximes and hydroxylamines generate NONO2 ions on treatment with iodine in glacial acetic acid. However, there is no correlation between relaxation and NONO2 formation. Compared to hydroxylamines, the oximes are less potent relaxing agents and not efficiently converted to NONO2 ions. We suggest that endothelium dependent relaxation is associated with a hydroxylamine like compound and is not directly related to NO.

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