Biochemical and Biophysical Research Communications
Salivary histatin as an inhibitor of a protease produced by the oral bacterium Bacteroides gingivalis
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Detection of periodontal disease activity based on histatin degradation in individuals with cerebral palsy
2022, HeliyonCitation Excerpt :The intent of increasing polyacrilamyde concentration was to increase the likelihood of visualization of low molecular weight proteins, such as histatins in the gel, as well as their degradation products. On the contrary, using HPLC, a more sensitive technique, McDonald et al. [8] observed that the degradation of histatin 1 occurs soon after 0.5 h of incubation in diluted WSS from periodontally healthy individuals, with 28% of the intact protein being degraded at 0.5 h, and 83% at 2 h. Besides, we observed that GI had an influence on the degradation of histatin 1 (Table 2), indicating that these proteins protect against the development of periodontal disease [12, 13, 14]. On the other hand, it was observed that histatin 5 degrades faster than histatin 1, as degradation products were observed as early as time point zero in saliva pools from all groups (Figure 1).
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