Interactions of cadmium with interstitial tissue of the rat testes: Uptake of cadmium by isolated interstitial cells
References (35)
- et al.
Toxic. appl. Pharmac.
(1980) - et al.
- et al.
Biochim. biophys. Acta
(1979) Analyt. Biochem.
(1976)Meth. Cell Biol.
(1976)- et al.
Toxic. appl. Pharmac.
(1980) - et al.
Biochim. biophys. Acta
(1979) - et al.
Toxic. appl. Pharmac.
(1976) - et al.
J. biol. Chem.
(1961) - et al.
Toxic. Lett.
(1984)
Nature, Lond.
J. Pharmac. exp. Ther.
J. Endocr.
Br. J. exp. Path.
Acta biol. med. germ.
Archs Path.
J. natn Cancer Inst.
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The environment and male reproduction: The effect of cadmium exposure on reproductive functions and its implication in fertility
2017, Reproductive ToxicologyCitation Excerpt :In vitro studies on Leydig cells isolated from rat testis and in vivo studies in mice demonstrated that, in the testis, the major route of entry of Cd might be a Zn transporter, since Zn selectively blocked Cd uptake [64,87–91]. A putative mechanism of Cd entry in the cells, including testis cells, is represented by ionic mimicry at the transporters belonging to the ZIP family of Zn transporters [64,87–91]. Cd intracellular concentration may rise by ZIP Zn transporters-mediated uptake from extracellular, as well as from intracellular vesicles milieu, in a Zn-competitive fashion, by potentially decreasing Zn intracellular concentration [64,90]; conversely, the effects of Cd on ZnT family of Zn transporters, that are responsible for Zn efflux from the cytosol and Zn uptake into intracellular vesicles in many organs, including testis, are unknown [92].
Cadmium: Toxic effects on the reproductive system and the embryo
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2003, Reproductive ToxicologyInhibition of 8-Hydroxyguanine repair in testes after administration of cadmium chloride to GSH-depleted rats
1997, Toxicology and Applied Pharmacology