Hydrolysis of the four stereoisomers of soman catalyzed by liver homogenate and plasma from rat, guinea pig and marmoset, and by human plasma☆
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Cited by (25)
In vitro toxicokinetic studies of cyclosarin: Molecular mechanisms of elimination
2014, Toxicology LettersCitation Excerpt :Illustrating complex underlying mechanisms, the classical reaction order of (+)-GF elimination could only be approximated with about −0.5 (Fig. 2C, increasing elimination with decreasing concentration). A similar tendency was detected by De Jong et al. (1988) for degradation of the C(−)P(+) GD enantiomer in rat liver homogenate. Possibly, over the examined range of initial GF concentrations, different plasma structures participate in GF enantiomers elimination, including enzymatic processes.
Detoxification of alkyl methylphosphonofluoridates by an oxime-substituted β-cyclodextrin - An in vitro structure-activity study
2014, Toxicology LettersCitation Excerpt :In the case of soman it is likely that structural parameters of the complex (e.g. incomplete inclusion of the alcohol residue into the CD cavity caused by steric effects of the methyl group next to the oxygen atom) are responsible for inhibition of the reaction between the phosphonate and a nucleophilic group on the ring. In addition, one has to consider that soman exists as a mixture of four stereoisomers of which the two P(−) enantiomers have a higher inhibitory potency toward AChE than the P(+) enantiomers (De Jong et al., 1988). It cannot be ruled out that 6-OxP-CD mediated detoxification of the P(−)C(−) and P(−)C(+) soman enantiomers proceeds at significantly different rates.
Influence of portal vein and liver artery ligation on the toxicokinetics of soman in rabbits
2002, Toxicology LettersApplication of capillary gas chromatography to the study of hydrolysis of the nerve agent VX in rat plasma
1997, Journal of Chromatography B: Biomedical ApplicationsHuperzine A as a pretreatment candidate drug against nerve agent toxicity
1994, Life Sciences
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This research was supported by Research Grant DAMD 17-85-G-5004 from U.S. Army Medical Research and Development Command.