Studies on the cellular pharmacology of N-(4-methylphenylsulfonyl)-N′-(4-chlorophenyl)-urea
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Synthesis and anticancer activity of 1,2,4-Benzothiadiazine-1,1-dioxides
2023, Results in Chemistry2-Anilinonicotinyl linked 2-aminobenzothiazoles and [1,2,4]triazolo[1,5-b] [1,2,4]benzothiadiazine conjugates as potential mitochondrial apoptotic inducers
2011, Bioorganic and Medicinal ChemistryCitation Excerpt :Sulfonylurea derivatives represent another important class of biologically active compounds with a broad spectrum of activity in several solid tumour models.23 A compound from this class, sulofenur (LY186641, 3) has been clinically evaluated in many cancer cell lines.24–26 These compounds are known to exert their biological effect by inhibiting DNA, RNA, or protein synthesis.27,28
Synthesis and antitumor evaluation of novel diarylsulfonylurea derivatives: Molecular modeling applications
2010, European Journal of Medicinal ChemistryCitation Excerpt :Diarylsulfonylureas have been identified as a new class of cancer chemotherapeutic agents with significant therapeutic efficacy against solid tumors [1–13]. Among these compounds, remarkable effectiveness of LY186641 (A, Sulofenur) and LY295501 (B) has been demonstrated against advanced colon adenocarcinoma xenografts intrinsically resistant to virtually all standard chemotherapeutic agents and had very significant activity against several pediatric tumors grown as xenografts (Scheme 1) [5,8,9,14–18]. Even though the mechanism of actions of these compounds has not been elucidated, it is estimated that diarylsulfonylureas act on mitochondria and are different from other clinically used antineoplastic agents in view of potency and toxicity [15,16].
Synthesis, DNA-binding ability and evaluation of antitumour activity of triazolo[1,2,4]benzothiadiazine linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates
2008, Bioorganic and Medicinal Chemistry1,2,4-Benzothiadiazine linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates: Synthesis, DNA-binding affinity and cytotoxicity
2007, Bioorganic and Medicinal Chemistry LettersInduction of G<inf>2</inf>/M phase arrest and apoptosis by a new synthetic anti-cancer agent, DW2282, in promyelocytic leukemia (HL-60) cells
2001, Biochemical PharmacologyCitation Excerpt :Diarylsulfonylureas are membrane-active and weak uncouplers of mitochondrial oxidative phosphorylation. Thus, the mitochondria have been suggested as a possible site of action [24–26]. However, it has also been reported that the anti-cancer activity of diarylsulfonylureas is not the result of their uncoupling action [26].