The role of the MDR1 (p-glycoprotein) gene in multidrug resistance in vitro and in vivo
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2023, GeneThe Expanding Role of APOL1 Risk in Chronic Kidney Disease and Cardiovascular Disease
2017, Seminars in NephrologyCitation Excerpt :Over a median period of 2.9 years, the minor allele of ABCB1 rs956825 in donors was associated with a five-fold increased risk of kidney allograft failure in additive and dominant models among recipients whose donors carried an APOL1 high-risk genotype. ABCB1 encodes for the multidrug resistance protein-1; this protein transports drugs, such as calcineurin inhibitors, out of cells.29 Lower ABCB1 expression may interact with variant apolipoprotein L1, leading to interstitial injury and eventual fibrosis.28,30
Paris saponin VII from trillium tschonoskii reverses multidrug resistance of adriamycin-resistant MCF-7/ADR cells via P-glycoprotein inhibition and apoptosis augmentation
2014, Journal of EthnopharmacologyCitation Excerpt :MDR is acquired via two major ways. One is the active export of drug from cells by the over-expression of P-glycoprotein (P-gp)(Roninson, 1992) and other ATP-binding cassette (ABC) transporters, which extrude the internalized drugs from the cancer cells. Another is direct suppression of apoptosis.