Sequential modifications of topoisomerase I activity in a camptothecin-resistant cell line established by progressive adaptation
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2004, Bioorganic and Medicinal ChemistryInhibition of topoisomerase II by the marine alkaloid ascididemin and induction of apoptosis in leukemia cells
2000, Biochemical PharmacologyCitation Excerpt :P388 and P388CPT5 murine leukemia cell lines sensitive and resistant to CPT, respectively, were kindly provided by Dr J.-F. Riou (Rhône-Poulenc Rorer, France). The P388CPT5 cell line resistant to campthotecin was derived from a stable clone of the P388CPT0.3 cell line obtained at the 42nd passage [24]. Both cell lines were grown in RPMI-1640 medium containing 0.01 mM 2-mercaptoethanol, 10 mM l-glutamine, 10% (v/v) fetal bovine serum, 100 IU/mL of penicillin, 2 μg/mL of streptomycin, 50 μg/mL of gentamycin, and 50 μg/mL of nystatin at 37° in a humidified atmosphere containing 5% CO2.
Relation between intracellular acidification and camptothecin-induced apoptosis in leukemia cells
2000, European Journal of Pharmaceutical SciencesCellular uptake and interaction with purified membranes of rebeccamycin derivatives
2000, European Journal of Pharmacology
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