Elsevier

Brain Research

Volume 134, Issue 3, 14 October 1977, Pages 393-405
Brain Research

Autoradiographic localization of opiate receptors in rat brain. III. The telencephalon

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Abstract

Opiate receptor distribution, determined by the autoradiographic localization of stereospecific [3Hdiprenorphine binding sites, was examined in the telencephalon. Areas showing very dense or dense localization of receptors included parts of the presubiculum and amygdala, patchy areas in the caudate-putamen and accumbens, the subfornical organ, the interstriatal nucleus of the striate terminalis and the anterior olfactory nucleus, pars externa. Lower densities were found in other parts of the hippocampal formation, the deeper part of the cerebral cortex, the entopenduncular nucleus, globus pallidus, nucleus triangularis septi and nucleus paratenialis. The significance of these findings is discussed in terms of the biochemical and physiological actions of opiates.

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      Furthermore, the caudate nucleus of the rat and the cat has neurons that respond to noxious mechanical stimuli in the periphery and that are somatotopically organized (Chudler et al., 1993; Lidsky et al., 1979; Richards and Taylor, 1982; Schneider and Lidsky, 1981). Also, there is evidence that striatum is densely populated with opiate receptors in rats (Atweh and Kuhar, 1977) and humans (Blackburn et al., 1988). In line with these findings, stimulation of the caudate nucleus has been shown to produce analgesic effects in the monkey (Lineberry and Vierck, 1975).

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    *

    Present address: Department of Neurology, Massachusetts General Hospital, 32 Fruit Street, Boston, Mass. 02114, U.S.A.

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