Research reportMechanism of kyotorphin-induced release of Met-enkephalin from guinea pig striatum and spinal cord
References (15)
- et al.
Analgesia induced by microinjection of morphine into, and electrical stimulation of, the nucleus reticularis paragigantocellularis of rat medulla oblongata
Neuropharmacology
(1978) - et al.
Potassium-induced release of enkephalins from rat striatal slices
Europ. J. Pharmacol.
(1978) - et al.
K-stimulated release of Leu- and Met-enkephalin from rat striatal slices: lack of effect of morphine and naloxone
Europ. J. Pharmacol.
(1979) - et al.
Effects of tyrosyl-arginine (kyotorphin), a new opioid dipeptide, on single neurons in the spinal dorsal horn of rabbits and the nucleus reticularis paragigantocellularis of rats
Neurosci. Lett.
(1980) - et al.
Morphine-like analgesia by a new dipeptide, l-tyrosyl-l-arginine (Kyotorphin) and its analogue
Europ. J. Pharmacol.
(1979) - et al.
Comparison of the analgesic effects of various opioid peptides by a newly devised intracisternal injection technique in conscious mice
Europ. J. Pharmacol.
(1979) - et al.
Regional distribution of a novel analgesic dipeptide kyotorphin (Tyr-Arg) in the rat brain and spinal cord
Brain Research
(1980)
Cited by (62)
Blockade of analgesic effects following systemic administration of N-methyl-kyotorphin, NMYR and arginine in mice deficient of preproenkephalin or proopiomelanocortin gene
2018, PeptidesCitation Excerpt :Kyotorphin is an analgesic dipeptide (l-tyrosine-l-arginine), which was isolated from bovine brain by use of in vivo analgesic assay system [1]. As kyotorphin causes an in vitro release of Met-enkephalin from the striatal slices [1,2], but shows neither binding activity to opioid receptors nor inhibiting activity of enkephalin degrading enzymes [1,3,4], this dipeptide is known as an enkephalin releaser. Although details remain elusive, there are several studies showing that opioid receptor antagonist, naloxone blocked various pharmacological or physiological actions of kyotorphin [5,6,3,7].
The orexigenic effect of kyotorphin in chicks involves hypothalamus and brainstem activity and opioid receptors
2013, NeuropeptidesCitation Excerpt :Kyotorphin (KTP) is a central dipeptide (l-tyrosyl–l-arginine) first isolated in the bovine brain (Takagi et al., 1979) and since found in other vertebrates including mice, rats, guinea pigs, rabbits (Shiomi et al., 1981; Ueda et al., 1980) and humans (Nishimura et al., 1991).
The pH-dependent conformational states of kyotorphin: A constant-pH molecular dynamics study
2007, Biophysical JournalCitation Excerpt :These results led to the suggestion that the dipeptide binds to a specific receptor (KTP receptor, KTPr) (56), triggering a cascade of events that leads to strong analgesia in the brain (57,63). Two mechanisms of action have been proposed: 1), direct activation of the KTPr, inducing Met-enkephalin release (which can activate the δ-receptor), followed by Gαi and phospholipase C activations (64,65); 2), a fast degradation of KTP, resulting in L-Arg, which is a potent substrate for nitric oxide synthase, with the NO thus formed inducing the release of Met-enkephalin (66). Despite the fact that several studies (45,53,54) confirm the existence of a KTPr, it has not yet been identified.
Interaction of endogenous ligands mediating antinociception
2006, Brain Research ReviewsDynorphin-mediated antinociceptive effects of l-arginine and SIN-1 (an NO donor) in mice
2006, Brain Research Bulletin