Elsevier

Brain Research

Volume 365, Issue 2, 19 February 1986, Pages 379-382
Brain Research

Conditioned rotational behavior in rats with unilateral 6-hydroxydopamine lesions of the substantia nigra

https://doi.org/10.1016/0006-8993(86)91654-9Get rights and content

Abstract

Rats with unilateral 6-hydroxydopamine lesions of the substantia nigra were given drug treatments which induced rotational behavior either ipsilateral (2.0 mg/kgd-amphetamine) or contralateral (0.5 mg/kg apomorphine) in a classical conditioning paradigm. Four days after four drug-environment pairings the rats rotated ipsilateral in the amphetamine-associated environment and contralateral in the apomorphine-associated environment. 6-OHDA-lesioned rats which received only drug or environment exposure exhibited a slight tendency to rotate ipsilateral in each environment. This conditioning of drug-induced rotational behavior may offer a useful model for the study of brain mechanisms in classical conditioning.

Reference (14)

  • AndenN.E. et al.

    Evidence for dopamine receptor stimulation by apomorphine

    J. Pharm. Pharmacol.

    (1967)
  • CareyR.J.

    Differential effects of limbic versus striatal dopamine loss on motoric function

    Behav. Brain Res.

    (1983)
  • Carey, R.J., A conditioned anti-Parkinsonian drug effect in the hemi-Parkinsonian rat,Psychopharmacology, in...
  • CostallB. et al.

    A comparison of circling models for the detection of anti-Parkinsonian activity

    Psychopharmacologia

    (1975)
  • CreeseI. et al.

    Nigrostriatal lesions enhance3H-apomorphine and3H-spiroperidol binding

    Eur. J. Pharmacol.

    (1979)
  • DeshaiesP. et al.

    Behavioral and biochemical evidence of apomorphine induced supersensitivity of the striatal dopamine receptors

    Neuropharmacology

    (1984)
  • LangA.E.

    Treatment of Parkinson's disease with agents other than levodopa and dopamine agonists: controversies and new approaches

    Can. J. Neurol. Sci.

    (1984)
There are more references available in the full text version of this article.

Cited by (0)

This research was supported by a Veterans Administration ministration Merit Review Grant and an N.I.M.H. Grant MH 33954.

View full text
Copyright © 1986 Published by Elsevier B.V.