Repeated reserpine administration up-regulates the transduction mechanisms of D1 receptors without changing the density of [3H]SCH 23390 binding
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6-OHDA-induced hemiparkinsonism and chronic l-DOPA treatment increase dopamine D1-stimulated [<sup>3</sup>H]-GABA release and [<sup>3</sup>H]-cAMP production in substantia nigra pars reticulata of the rat
2008, NeuropharmacologyCitation Excerpt :We found that the increased sensitivity to D1 receptor stimulation caused by either denervation or l-DOPA is not associated with increased number of dopamine receptors in the SNr. Thus the effects of these treatments in the SNr are in concordance with prior findings in the striatum, where D1-like receptors number and mRNA appear unchanged or diminished after dopaminergic denervation (Missale et al., 1989; Gerfen et al., 1990; Cai et al., 2002). The implication of the binding studies is that the increased response is caused by increased activity in the signaling pathway that takes place downstream from the receptor agonist binding step.
Metabotropic glutamate receptor/phospholipase C pathway is increased in rat brain at the end of pregnancy
2007, Neurochemistry InternationalRapidly induced dopaminergic supersensitivity: D1/D2 receptor participation and its prevention by an MAO-inhibitor
2006, Pharmacology Biochemistry and BehaviorAltered expression of regulators of G-protein signaling (RGS) mRNAs in the striatum of rats undergoing dopamine depletion
2003, Biochemical PharmacologyCitation Excerpt :Although small variations cannot be excluded (due to the sensitivity of the detection), none of these transcripts appeared significantly altered after 6-hydroxydopamine lesion (not shown). The repeated administration of reserpine (for 5 days) was previously found to deplete striatal dopamine by about 80% [38]. After such treatment, a significant decrease in the mRNA levels was observed for the most abundant RGS species detected in the striatum (Fig. 5).
Dopaminergic abnormalities in amygdaloid nuclei in major depression: A postmortem study
2002, Biological PsychiatryCitation Excerpt :In the human amygdala, both major classes of receptors, D1-like and D2-like including D3 receptors, are present. The pattern of distribution of DA receptors described in this study is similar to the distribution of D1, D2, and D3 receptors observed by others (Gurevich and Joyce 1999; Murray et al 1994; Ryoo et al 1998). [ 125I]Epidepride binding sites have the characteristics of both D2 and D3 receptors depending on the amygdaloid nuclei, and these sites are unevenly distributed among amygdaloid complex (Murray et al 1994).