Elsevier

Brain Research

Volume 568, Issues 1–2, 24 December 1991, Pages 323-324
Brain Research

The effect of gangliosides upon recovery of aspartate/glutamatergic synapses in striatum after lesions of the rat sensorimotor cortex

https://doi.org/10.1016/0006-8993(91)91419-2Get rights and content

Abstract

Changes in neuronal uptake of glutamate/aspartate were studied in the striatum after unilateral destruction of the sensorimotor cortex and injection of GM1 ganglioside. A 75% decrease of uptake of [3H]d-aspartate in the striatum ipsilateral to the cortical lesion was detected at 10 days postlesion compared to the contralateral striatum. We demonstrated that injection of gangliosides during 10 days returned the uptake of [3H]d-aspartate to control level and compensated loss of the synapses in the striatum after the cortical lesion and thereby can prevent aberrant axonal overgrowth in the contralateral striatum.

Cited by (7)

  • Chapter 25 CNS Pharmacology of gangliosides

    1994, Progress in Brain Research
View all citing articles on Scopus
View full text