Research reportEffect of nitric oxide on mitogenesis and proliferation of cerebellar glial cells
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Nitric oxide regulates the proliferation of chick embryo retina cells by a cyclic GMP-independent mechanism
2006, International Journal of Developmental NeuroscienceCitation Excerpt :Our results have shown that inhibition of NOS with NARG was not able to promote significant effects on [3H]-thymidine incorporation, meaning that NO produced by neurons is not synthesized in sufficient amounts to inhibit proliferation of glial cells in our mixed cultures at the period studied. However, another interesting possibility is that NO regulates glial cell proliferation after CNS trauma or neurodegenerative diseases (Garg et al., 1992). The induction of iNOS in glial cells after citokine or lipopolysacaride exposure promotes the synthesis of large amounts of NO that in turn regulates proliferation of the same or neighbour cells.
Ceramide in nitric oxide inhibition of glioma cell growth: Evidence for the involvement of ceramide traffic
2003, Journal of Biological ChemistryNitric oxide donors selectively potentiate thrombin-stimulated p70(S6k) activity and morphological changes in Swiss 3T3 cells
1999, Biochemical and Biophysical Research Communications
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