Altered dopamine receptor mediated signal transmission in the striatum of aged rats
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Cited by (30)
The modulation of striatal dopamine release correlates with water-maze performance in aged rats
2009, Neurobiology of AgingCitation Excerpt :The control of DA release in the striatum involves dopaminergic D2 autoreceptors and a variety of heteroreceptors, including inhibitory 5-HT1B and excitatory nicotinic ones (e.g., Joseph et al., 1988; Kurotani et al., 2003; Scholze et al., 2007; Wonnacott et al., 2000). As both the D2 receptor binding (e.g., Alfaro et al., 2004; May and Sugawa, 1993; Suzuki et al., 2001) and the striatal DA–ACh interactions (Kurotani et al., 2003) are reduced in aged rats, age-related alterations of the regulation of the evoked neurotransmitter release by striatal dopaminergic terminals seemed expectable. Concerning striatal 5-HT1B receptors, we are not aware of any study that paid attention to their functional status in aged animals, except the one by Gozlan et al. (1990), who reported on a large age-related decrease.
Spatial reference- (not working- or procedural-) memory performance of aged rats in the water maze predicts the magnitude of sulpiride-induced facilitation of acetylcholine release by striatal slices
2007, Neurobiology of AgingCitation Excerpt :This observation is at variance with a previous report by Zsilla et al. [89], who found both the storage and the release of striatal acetylcholine to be weaker in old rats, as also observed in our present experiment, but could not evidence an age-related modification of the effects of sulpiride. However, in line with our present data suggesting a weaker responsiveness of D2 receptor-mediated functions in aged rats, previous studies have shown that aging was accompanied by a decrease of D2 receptor binding in the rat striatum [1,51,78]. Such reduced binding might be due to a loss of D2 autoreceptors subsequent to the well-known reduction of nigrostriatal dopaminergic axon terminals in the striatum, an observation which is also compatible with an age-related decrease of the activity of dopamine transporters [33,37,67], or with a reduced dopamine concentration or release ([36,54,88], but see [28,79]).
Functional recovery of the striatal cholinergic system in aged rats by adenoviral vector-mediated gene transfer of dopamine D<inf>2</inf> receptor
2006, Mechanisms of Ageing and DevelopmentIncreased sensitization to morphine-induced oral stereotypy in aged rats
2004, Pharmacology Biochemistry and BehaviorThe age-associated changes of dopamine-acetylcholine interaction in the striatum
2003, Experimental Gerontology