Review articleThe role of iron in oxygen radical mediated lipid peroxidation☆
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2019, Brain ResearchCitation Excerpt :Our previous study showed evidence of cortical reorganization with hUTC treatment in this model (Orczykowski et al., 2018), so we propose that the treatment induced reduction in iron and oxidative damage in our model may have reduced secondary injury and enabled more effective reorganization rather than reducing reconstructed lesion volume. The positive feedback between unbound iron and ROS is well documented in its contribution to neuronal damage following stroke (Minotti and Aust, 1989; Selim and Ratan, 2004). Initially, lipids are peroxidized in the presence of ROS.
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Work supported by grants GM 33443 and HL 33543 from the National Institutes of Health. G.M. thanks Associazione Italiana Ricerca sul Cancro and the Fulbright Organization for financial support.