The role of iron in oxygen radical mediated lipid peroxidation

doi:10.1016/0009-2797(89)90087-2

Chemico-Biological Interactions

Volume 71, Issue 1, 1989, Pages 1-19

https://doi.org/10.1016/0009-2797(89)90087-2 Get rights and content

Abstract

The role of iron in the peroxidation of polyunsaturated fatty acids is reviewed, especially with respect to the involvement of oxygen radicals. The hydroxyl radical can be generated by a superoxide-driven Haber-Weiss reaction or by Fenton's reaction; and the hydroxyl radical can initiate lipid peroxidation. However, lipid peroxidation is frequently insensitive to hydroxyl radical scavengers or superoxide dismutase. We propose that the hydroxyl radical may not be involved in the peroxidation of membrane lipids, but instead lipid peroxidation requires both Fe²⁺ and Fe³⁺. The inability of superoxide dismutase to affect lipid peroxidation can be explained by the fact that the direct reduction of iron can occur, exemplified by rat liver microsomal NADPH-dependent lipid peroxidation. Catalase can be stimulatory, inhibitory or without affect because H₂O₂ may oxidize some Fe²⁺ to form the required Fe³⁺, or, alternatively, excess H₂O₂ may inhibit by excessive oxidation of the Fe²⁺. In an analogous manner reductants can form the initiating complex by reduction of Fe³⁺, but complete reduction would inhibit lipid peroxidation. All of these redox reactions would be influenced by iron chelation.

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^☆: Work supported by grants GM 33443 and HL 33543 from the National Institutes of Health. G.M. thanks Associazione Italiana Ricerca sul Cancro and the Fulbright Organization for financial support.

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Review articleThe role of iron in oxygen radical mediated lipid peroxidation☆

Abstract

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Review article
The role of iron in oxygen radical mediated lipid peroxidation☆