Di-isopropyl phosphofluoridate-induced antinociception: possible role of endogenous opioids☆
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Cited by (32)
Multiple neurological effects associated with exposure to organophosphorus pesticides in man
2023, ToxicologyCitation Excerpt :Animal studies confirmed that effects on cognition after exposure to low levels of certain OP compounds, such as dichlorvos, were not related to inhibition of AChE in rats. In addition, OP compounds may also affect the metabolism of neuropeptide upon releasing of endogenous opiates (Koehn et al., 1980; Kubek et al., 1997; Dési and Nagymajtényi, 1999). Administration of various OP compounds might have different behavioral presentation, suggesting that their resulting effects are not caused only by inhibition of AChE (van Dongen and Wolthuis, 1989; Pope et al., 1992).
Neurotoxic effects of organophosphorus pesticides and possible association with neurodegenerative diseases in man: A review
2018, ToxicologyCitation Excerpt :Several animal studies have shown that cognitive enhancing action of low doses of certain OPs, such as dichlorvos, in rats were unrelated to AChE inhibition. It was suggested that OPs may affect neuropeptide metabolism through the release of endogenous opiates and/or through interactions with yet unidentified receptors (Kohen et al., 1980; Kubek et al., 1997; Desi and Nagymajtenyi, 1999). It has also been observed that administration of different OPs has different behavioral presentation, suggesting that observed effects are not entirely a result of AChE inhibition (Pope et al., 1992; van Dongen and Wolthuis, 1989v).
Neurotoxic effects in patients poisoned with organophosphorus pesticides
2010, Environmental Toxicology and PharmacologyCitation Excerpt :Several animal studies have shown that the cognitive enhancing action of low doses of certain organophosphates, such as dichlorvos (in rats) was unrelated to AChE inhibition. It was suggested that OP compounds may affect neuropeptide metabolism through the release of endogenous opiates and/or through interactions with yet unidentified receptors (Kohen et al., 1980; Kubek et al., 1997; Dési and Nagymajtényi, 1999). It has also been observed that administration of different OP compounds has different behavioral presentation, suggesting that observed effects are not entirely a result of AChE inhibition (van Dongen and Wolthuis, 1989; Pope et al., 1992).
The potential for toxic effects of chronic, low-dose exposure to organophosphates
2001, Toxicology LettersCitation Excerpt :Finally, the effects of OP compounds on neuropeptide metabolism may be an emerging mechanism. Early observations included effects such as long lasting analgesia (Clement and Copeman, 1984) which may be mediated by the release of endogenous opiates (Koehn et al., 1980) and other neuropeptide systems (Kubek et al., 1997). Also, it has been observed that behavioural changes associated with DFP administration are different from those with chlorpyrifos, suggesting that these effects were not entirely a result of acetylcholinesterase inhibition (VanDongen and Wolthuis, 1989; Bushnell et al., 1993).
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Supported in part by NIH Grant NS06455